The relationship between insulin resistance and polymorphisms of the endothelial nitric oxide synthase gene in patients with coronary artery disease
Open accessAbstract
Nitric oxide (NO) regulates endothelial function and is believed to prevent atherogenesis. In endothelial cells, endothelial nitric oxide synthase (eNOS) is expressed constitutively, and regulates NO synthesis. A mutation of the eNOS gene has been associated with the development of coronary artery disease (CAD). The development of CAD is also influenced by insulin resistance, and recent studies suggest that NO might affect cellular insulin activity. We investigated the association between eNOS polymorphisms and insulin resistance in patients with CAD. We screened 45 patients with a history of myocardial infarction (MI), angina pectoris (AP), or coronary spasm. Genotypes were determined by polymerase chain reaction-restriction fragment-length polymorphism analysis. We examined two polymorphisms of the eNOS gene (The T(-786)-->C variant and the missense Glu298Asp variant). Insulin resistance was measured by determining the plasma immunoreactive insulin concentration at the 120 min time point (IRI 120) of a 75 g oral glucose tolerance test. The IRI 120 of the T(-786)-->C variant group was higher than that for the control group (p<0.05). This finding demonstrates that the T(-786)-->C mutation in the eNOS gene decreases insulin sensitivity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several studies have associated a T(−786)C variant of the NOS3 gene with insulin resistance.
“Most notably, several studies have associated a T(−786)C variant of the NOS3 gene with insulin resistance [318-320].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [319]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nitric oxide: an endogenous modulator of leukocyte adhesion.
Kubes, P., Suzuki, M., & Granger, D. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4651 · Cited by 3,052 · see citing works
Garg, U. C., & Hassid, A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114081 · Cited by 2,154 · see citing works
Hyperinsulinemia as an independent risk factor for ischemic heart disease
Després, J.-P., Lamarche, B., Mauriège, P., Cantin, B., Dagenais, G. R., Moorjani, S., & Lupien, P.-J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604113341504 · Cited by 1,699 · see citing works
ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91481-4 · Cited by 1,437 · see citing works
Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling.
Rudic, R. D., Shesely, E. G., Maeda, N., Smithies, O., Segal, S. S., & Sessa, W. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1699 · Cited by 821 · see citing works
Nakayama, M., Yasue, H., Yoshimura, M., Shimasaki, Y., Kugiyama, K., Ogawa, H., Motoyama, T., Saito, Y., Ogawa, Y., Miyamoto, Y., et al. (1999) · Circulation · doi:10.1161/01.cir.99.22.2864 · Cited by 777 · see citing works
Duplain, H., Burcelin, R., Sartori, C., Cook, S., Egli, M., Lepori, M., Vollenweider, P., Pedrazzini, T., Nicod, P., Thorens, B., et al. (2001) · Circulation · doi:10.1161/01.cir.104.3.342 · Cited by 533 · see citing works
Hingorani, A. D., Liang, C. F., Fatibene, J., Lyon, A., Monteith, S., Parsons, A., Haydock, S. F., Hopper, R., Stephens, N. G., O’Shaughnessy, K. M., et al. (1999) · Circulation · doi:10.1161/01.cir.100.14.1515 · Cited by 522 · see citing works
Nitric Oxide Reversibly Inhibits the Migration of Cultured Vascular Smooth Muscle Cells
Sarkar, R., Meinberg, E., Stanley, J. C., Gordon, D., & Webb, R. C. (1996) · Circulation Research · doi:10.1161/01.res.78.2.225 · Cited by 419 · see citing works
Yoshimura, M., Yasue, H., Nakayama, M., Shimasaki, Y., Sumida, H., Sugiyama, S., Kugiyama, K., Ogawa, H., Ogawa, Y., Saito, Y., et al. (1998) · Human Genetics · doi:10.1007/s004390050785 · Cited by 404 · see citing works
Inhibition of low‐density lipoprotein oxidation by nitric oxide Potential role in atherogenesis
Hogg, N., Kalyanaraman, B., Joseph, J., Struck, A. T., & Parthasarathy, S. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81706-6 · Cited by 400 · see citing works
Endothelial Nitric Oxide Synthase Gene Polymorphism and Acute Myocardial Infarction
Hibi, K., Ishigami, T., Tamura, K., Mizushima, S., Nyui, N., Fujita, T., Ochiai, H., Kosuge, M., Watanabe, Y., Yoshii, Y., et al. (1998) · Hypertension · doi:10.1161/01.hyp.32.3.521 · Cited by 351 · see citing works
Endothelial Nitric Oxide Production and Insulin Sensitivity
Petrie, J. R., Ueda, S., Webb, D. J., Elliott, H. L., & Connell, J. (1996) · Circulation · doi:10.1161/01.cir.93.7.1331 · Cited by 319 · see citing works
Shimasaki, Y., Yasue, H., Yoshimura, M., Nakayama, M., Kugiyama, K., Ogawa, H., Harada, E., Masuda, T., Koyama, W., Saito, Y., et al. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00167-3 · Cited by 316 · see citing works
嶋崎, 幸. (1999) · Medical Entomology and Zoology · doi:10.11501/3166056 · Cited by 292 · see citing works
Kapur, S., Bédard, S., Marcotte, B., Côté, C. H., & Marette, A. (1997) · Diabetes · doi:10.2337/diab.46.11.1691 · Cited by 225 · see citing works
Chataigneau, T., Félétou, M., Huang, P. L., Fishman, M. C., Duhault, J., & Vanhoutte, P. M. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702300 · Cited by 206 · see citing works
Lacolley, P. J., Gautier, S., Poirier, O., Pannier, B., Cambien, F., & Bénétos, A. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816010-00006 · Cited by 175 · see citing works
Nakayama, M., Yasue, H., Yoshimura, M., Shimasaki, Y., Ogawa, H., Kugiyama, K., Mizuno, Y., Harada, E., Nakamura, S., Ito, T., et al. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01041-9 · Cited by 157 · see citing works
The Framingham Study : ITS 50-Year Legacy and Future Promise
Kannel, W. B. (2000) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat1994.6.60 · Cited by 148 · see citing works
Diffuse disorder of coronary artery vasomotility in patients with coronary spastic angina
Okumura, K., Yasue, H., Matsuyama, K., Ogawa, H., Kugiyama, K., Ishizaka, H., Sumida, H., Fujii, H., Matsunaga, T., & Tsunoda, R. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00432-7 · Cited by 138 · see citing works
Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase
Faraci, F. M., Sigmund, C. D., Shesely, E. G., Maeda, N., Heistad, D. D., & Rummelhart), (. T. T. A. O. K. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.2.h564 · Cited by 137 · see citing works
Insulin as a mitogenic factor: Role in the pathogenesis of cardiovascular disease
Stout, R. W. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)90041-u · Cited by 103 · see citing works
Egashira, K., Inou, T., Yamada, A., Hirooka, Y., & Takeshita, A. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115646 · Cited by 95 · see citing works
Fatini, C., Gensini, F., Sticchi, E., Battaglini, B., Angotti, C., Conforti, M. L., Generini, S., Pignone, A. M., Abbate, R., & Matucci‐Cerinic, M. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01069-0 · Cited by 79 · see citing works
Kapur, S., Bedard, S., Marcotte, B., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.11.1691 · Cited by 56 · see citing works
T-786C Polymorphism in Endothelial NO Synthase Gene Affects Cerebral Circulation in Smokers
Nasreen, S., Nabika, T., Shibata, H., Moriyama, H., Yamashita, K., Masuda, J., & Kobayashi, S. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000013286.60021.fe · Cited by 48 · see citing works
Lipoproteins and cardiovascular risk-from genetics to CHD prevention.
Cullen, P., Funke, H., Schulte, H., & Assmann, G. (1997) · Journal of atherosclerosis and thrombosis · doi:10.5551/jat1994.4.51 · Cited by 46 · see citing works
Suzuki, M., Nishizaki, M., Nishizaki, M., Arita, M., Kakuta, T., & Numano, F. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(96)00011-3 · Cited by 39 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Regulation of obesity and insulin resistance by nitric oxide
Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274 · see citing works
Hermida, N., & Balligand, J. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5537 · Cited by 105 · see citing works
Association of NOS3 gene with metabolic syndrome in hypertensive patients
Fernández, M., Ruiz, R., Gonzalez, M., Ramírez‐Lorca, R., Couto, C., Ramos, A., Gutierrez-Tous, R., de Rivera, J. M. P. S., Ruiz, A., Grilo, A., et al. (2004) · Thrombosis and Haemostasis · doi:10.1160/th04-02-0103 · Cited by 55 · see citing works
Endothelial Nitric Oxide Synthase Haplotypes Are Associated with Features of Metabolic Syndrome
González‐Sánchez, J. L., Martin, N. G., Sáez, M. E., Aben, K. K. H., Martínez-Calatrava, M. J., & Serrano‐Ríos, M. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.075176 · Cited by 44 · see citing works
Zhang, Z., & Guo, J. (2024) · Antioxidants · doi:10.3390/antiox14010038 · Cited by 40 · see citing works
Ciftci, C., Melil, S., Çebi, Y., Ersöz, M., Çağatay, P., Kılıçgedik, M., & Duman, B. S. (2008) · Lipids in Health and Disease · doi:10.1186/1476-511x-7-5 · Cited by 35 · see citing works
Tamemoto, H., Ishikawa, S., & Kawakami, M. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.12.019 · Cited by 32 · see citing works
Chien, W., Yang, K., Eng, H.-L., Hu, Y.-H., Lee, P. Y., Wang, S., & Wang, P. W. (2005) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70168-4 · Cited by 30 · see citing works
Say, Y.-H. (2017) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-017-0142-x · Cited by 27 · see citing works
Endothelial nitric oxide synthase gene polymorphisms and prostate cancer risk in S erbian population
Branković, A., Brajušković, G. N., Dobrijević, Z., Vukotić, V. D., Cerović, S. J., Pavicevic, D. S., & Romac, S. P. (2013) · International Journal of Experimental Pathology · doi:10.1111/iep.12045 · Cited by 27 · see citing works
Antiobesogenic Role of Endothelial Nitric Oxide Synthase
Sansbury, B. E., & Hill, B. G. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800254-4.00013-1 · Cited by 25 · see citing works
MITCHELL, A., PACE, M., NURNBERGER, J., WENZEL, R., Siffert, W., Philipp, T., & SCHAFERS, R. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.03.002 · Cited by 21 · see citing works
Meng, Z., Wu, J., Zhu, Y., Zhou, W., Fu, C., Liu, X., Liu, S., Ni, M., & Guo, S. (2020) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-020-2716-4 · Cited by 20 · see citing works
Cozma, A., Fodor, A., Orasan, O. H., Vulturar, R., SAMPLELEAN, D., Negrean, V., MUREȘAN, C. C., Suharoschi, R., & Sitar-Tăut, A. (2019) · In Vivo · doi:10.21873/invivo.11573 · Cited by 14 · see citing works
Insulin sensitivity and resistin expression in nitric oxide-deficient rats
Juan, C., Chang, C. L., Chuang, T., Huang, S., Kwok, C., & Ho, L. T. (2006) · Diabetologia · doi:10.1007/s00125-006-0403-4 · Cited by 12 · see citing works
Miyazaki, T., Shimada, K., Iwama, Y., Kume, A., Sumiyoshi, K., Sato, Y., Ohmura, H., Watanabe, Y., Mokuno, H., & Daida, H. (2008) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.e515 · Cited by 11 · see citing works
Reddy, R. C., Hao, Y., Lee, S.-H., Gangireddy, S. R., Owyang, C., & Dimagno, M. J. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00442.2006 · Cited by 8 · see citing works
Daniela Seelenfreund, H., Lobos, S. R., Quesada, A., Saavedra, J. M., Wolff, C., López-Stewart, G., Araya, A. V., & Durruty, P. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.01.029 · Cited by 6 · see citing works
New directions in the treatment of heart failure: Targeting free fatty acid oxidation
Fragasso, G., Spoladore, R., Bassanelli, G., Cuko, A., Montano, C., Salerno, A., & Margonato, A. (2007) · Current Heart Failure Reports · doi:10.1007/s11897-007-0018-1 · Cited by 6 · see citing works
Albegali, A. A., Shahzad, M., Mahmood, S., Ullah, M. I., Amar, A., & Sajjad, O. (2019) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-019-00775-6 · Cited by 4 · see citing works
The role of trimetazidine in heart failure
Fragasso, G., Cuko, A., Salerno, A., Baratto, F., Gardini, C., & Margonato, A. (2007) · Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele · Cited by 3 · see citing works
Fragasso, G., Palloshi, A., & Cuko, A. (2006) · Heart and Metabolism
The anti-obesogenic effects of nitric oxide.
Sansbury, B. E. (2014) · doi:10.18297/etd/1262
Tangadi, D., Bhutani, N., & Bhavsar, P. (2020) · Journal of Evolution of Medical and Dental Sciences · doi:10.14260/jemds/2020/180
Ciftci, C., Melil, S., Çebi, Y., Ersöz, M., Çağatay, P., Kılıçgedik, M., & Duman, S. (2015)
- Authors
- Yoshimura, T., Hisatomi, A., Kajihara, S., Yasutake, T., Ogawa, Y., Mizuta, T., Ozaki, I., Utsunomiya, T., & Yamamoto, K.
- Affiliations
- Saga University (JP)
- Saga Medical School Hospital (JP)
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2003
- Volume
- 10
- Issue
- 1
- Pages
- 43-47
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- OpenAlex
- W2075942862
- Cited by
- 25
- References
- 28
- Citations by year
- 2024: 1 · 2020: 2 · 2019: 2 · 2017: 1 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- insulin resistance, endothelial nitric oxide synthase, eNOS gene polymorphism, coronary artery disease, nitric oxide, insulin sensitivity, myocardial infarction, angina pectoris, coronary vasospasm
- MeSH terms
- Coronary Disease, Endothelium, Vascular, Female, Gene Frequency, Genotype, Humans, Insulin Resistance, Male, Middle Aged, Polymorphism, Genetic, Genetic Variation, Polymerase Chain Reaction, Nitric Oxide Synthase, Mutation, Missense, Nitric Oxide Synthase Type III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
