Appropriate Level of Low-Density Lipoprotein Cholesterol for Secondary Prevention of Coronary Artery Disease
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AIM: Current Japanese guidelines state the target level of low-density lipoprotein cholesterol (LDL-C) of <100mg/dL for secondary prevention of coronary artery disease (CAD). However, this level was set considering the results of trials mainly conducted in Western countries. In addition, the effect of achieving target LDL-C on secondary prevention is unknown. METHODS: We examined the effects of achieving target LDL-C on clinical outcomes. Patients who underwent percutaneous coronary intervention at Juntendo University Hospital (Tokyo, Japan) from 2004 to 2010 and received follow-up coronary angiography (CAG) were analyzed. The study population was divided into two groups based on the follow-up LDL-C. The incidence of major adverse cardiovascular events within 3 years after the follow-up CAG was examined. RESULTS: A total of 1321 consecutive patients were enrolled. Sixty-three percent of the patients achieved the target LDL-C. The rate of 3-year events was lower in the group that achieved the target LDL-C (achieved group). The adjusted relative risk reduction in the achieved group was 26% (p=0.02). In the sub-analysis among the four groups stratified by baseline LDL-C of 140 and follow-up LDL-C of 100, the adjusted hazard ratio for 3-year events was 1.84 (95% confidence interval; 1.10-3.24)in Group 3 (baseline <140, follow-up ≥100) and 2.05 (1.18-3.74) Group 4 (baseline ≥140, follow-up ≥100) [Group 2 (baseline ≥140, follow-up <100) as reference]. CONCLUSIONS: Our data suggested that follow-up LDL-C <100mg/dL was appropriate for secondary prevention of CAD in Japanese population.
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The risk of cardiovascular events was extremely low in patients with hypo-LDL cholesterolemia caused by gene mutations.
“A Mendelian randomization analysis found that the risk of cardiovascular events was extremely low in patients with hypo-LDL cholesterolemia that was caused by gene mutations630).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [630]
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Projections of Global Mortality and Burden of Disease from 2002 to 2030
Mathers, C. D., & Loncar, D. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030442 · Cited by 11,386 · see citing works
Stone, N. J., Robinson, J. G., Lichtenstein, A. H., Bairey Merz, C. N., Blum, C. B., Eckel, R. H., Goldberg, A. C., Gordon, D., Levy, D., Lloyd-Jones, D. M., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437738.63853.7a · Cited by 7,081 · see citing works
Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes
Cannon, C. P., Braunwald, E., McCabe, C. H., Rader, D. J., Rouleau, J. L., Belder, R., Joyal, S. V., Hill, K. A., Pfeffer, M. A., & Skene, A. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040583 · Cited by 4,938 · see citing works
Cardiovascular disease in Europe: epidemiological update
Nichols, M. S., Townsend, N. P., Scarborough, P., & Rayner, M. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht356 · Cited by 1,349 · see citing works
Growing Epidemic of Coronary Heart Disease in Low- and Middle-Income Countries
Gaziano, T. A., Bitton, A., Anand, S., Abrahams‐Gessel, S., & Murphy, A. (2009) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2009.10.002 · Cited by 1,177 · see citing works
Kashiwagi, A., Kasuga, M., Araki, E., Oka, Y., Hanafusa, T., Ito, H., Tominaga, M., Oikawa, S., Noda, M., Kawamura, T., et al. (2012) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2012.00207.x · Cited by 902 · see citing works
Law, M. R., Wald, N., Wu, T., Hackshaw, A. K., & Bailey, A. (1994) · BMJ · doi:10.1136/bmj.308.6925.363 · Cited by 305 · see citing works
Kashiwagi, A. (2012) · Medical Entomology and Zoology · Cited by 211 · see citing works
Sakamoto, T., Kojima, S., Ogawa, H., Shimomura, H., Kimura, K., Ogata, Y., Sakaino, N., & Kitagawa, A. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.11.031 · Cited by 99 · see citing works
Guidelines for Secondary Prevention of Myocardial Infarction (JCS 2011)
JCS Joint Working Group (2012) · Circulation Journal · doi:10.1253/circj.cj-66-0053 · Cited by 92 · see citing works
Dohi, T., Miyauchi, K., Okazaki, S., Yokoyama, T., Yanagisawa, N., Tamura, H., Kojima, T., Yokoyama, K., Kurata, T., & Daida, H. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.12.001 · Cited by 76 · see citing works
Self-citationCoronary heart disease in high-risk populations: Lessons from Finland
Grundy, S. M., Wilhelmsen, L., Rose, G., et al. (1990) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a059730 · Cited by 55 · see citing works
Guidelines for Secondary Prevention of Myocardial Infarction (JCS 2011) : Digest Version
Ogawa, H., Adachi, H., Hayashi, T., et al. (2012) · Japanese Circulation Journal-english Edition · Cited by 53 · see citing works
Teramoto, T., Sasaki, J., Ishibashi, S., Birou, S., Daida, H., Dohi, S., Egusa, G., Hiro, T., Hirobe, K., Iida, M., et al. (2013) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.18473 · Cited by 17 · see citing works
Self-citationComment on the New Guidelines in USA by the JAS Guidelines Committee
Arai, H., Sasaki, J., & Teramoto, T. (2014) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.ed001 · Cited by 16 · see citing works
Teramoto, T., Sasaki, J., Ishibashi, S., Birou, S., Daida, H., Dohi, S., Egusa, G., Hiro, T., Hirobe, K., Iida, M., et al. (2013) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.19158 · Cited by 11 · see citing works
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Research works printed but not linked: 1
- Schwartz GG, Olsson AG, Ezekowitz MD, Ganz P, Oliver MF, Waters D, Zeiher A, Chaitman BR, Leslie S, Stern T; vention of Myocardial Infarction (JCS 2011). Circ J, 2013; 77: 231-248
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Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
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- Authors
- Naito, R., Miyauchi, K., Konishi, H., Tsuboi, S., Ogita, M., Dohi, T., Kasai, T., Tamura, H., Okazaki, S., Isoda, K., & Daida, H.
- Affiliations
- Juntendo University (JP)
- ORCID
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2016
- Volume
- 23
- Issue
- 4
- Pages
- 413-421
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- OpenAlex
- W2253400961
- Cited by
- 10
- References
- 17
- Citations by year
- 2024: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- LDL cholesterol, LDL-C target levels, secondary prevention, coronary artery disease, percutaneous coronary intervention, major adverse cardiovascular events, Japanese population, lipid-lowering therapy
- MeSH terms
- Aged, Coronary Artery Disease, Female, Humans, Japan, Cholesterol, LDL, Longitudinal Studies, Male, Middle Aged, Risk, Proportional Hazards Models, Treatment Outcome, Coronary Angiography, Secondary Prevention, Percutaneous Coronary Intervention
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