Cardio-Ankle Vascular Index to Screen Cardiovascular Diseases in Patients with End-Stage Renal Diseases
Open accessAbstract
BACKGROUND: Cardiovascular diseases constitute major causes of death in patients with chronic kidney diseases. An increase in arterial stiffness predicts the presence of cardiovascular diseases; however, non-invasive arterial stiffness parameters such as pulse wave velocity are confounded by blood pressure. METHODS: A new arterial stiffness parameter beta for the arterial tree, cardio-ankle vascular index (CAVI), was measured. To examine the usefulness of CAVI to screen for the presence of cardiovascular diseases, cross-sectional studies were performed on 68 patients undergoing chronic hemodialysis. RESULTS: Stepwise regression analysis indicated that CAVI significantly correlated to age (beta=0.05, p<0.01) but not blood pressure. In addition, CAVI was higher in diabetics than non-diabetics (8.39+/-0.37 vs 7.63+/-0.57, p<0.05). Furthermore, CAVI was markedly elevated in patients with a history of cardiovascular diseases (8.69+/-0.23 vs 6.66+/-0.28, p<0.01). Analysis using the ROC curve has demonstrated that CAVI of 7.55 constitutes the cut-off value for the presence of cardiovascular diseases with both sensitivity and specificity of 0.79. CONCLUSION: The present findings suggest that CAVI can be used as a screening test to detect for the presence of cardiovascular diseases in patients undergoing hemodialysis.
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Patients with cerebral infarction, CVD, CKD, and vasculitis have high CAVI values.
“The CAVI increases with age28), and patients with cerebral infarction, CVD29), chronic kidney disease (CKD), and vasculitis have high CAVI values.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [29]
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- Authors
- Takenaka, T., Hoshi, H., Kato, N., Kobayashi, K., Takane, H., Shoda, J., & Suzuki, H.
- Affiliations
- Saitama Medical University (JP)
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2008
- Volume
- 15
- Issue
- 6
- Pages
- 339-344
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- OpenAlex
- W1963829731
- Cited by
- 45
- References
- 18
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 7
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal and Vascular Pathologies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- cardio-ankle vascular index, cardiovascular screening, end-stage renal disease, hemodialysis, arterial stiffness, chronic kidney disease, diabetes mellitus, pulse wave velocity, cut-off values
- MeSH terms
- Aged, Ankle, Blood Pressure, Blood Vessels, Cardiovascular Diseases, Diabetes Mellitus, Female, Renal Dialysis, Humans, Kidney Failure, Chronic, Male, Mass Screening, Middle Aged, ROC Curve, Sensitivity and Specificity
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