Lesion and stimulation of the ventral tegmental area increases cholinergic activity in the rat brain
Open accessAbstract
Our previous study indicated that unilateral lesion of the ventral tegmental area (VTA) facilitates contralateral VTA stimulation-induced feeding or exploration. The present study was aimed to determine the possible role of the central cholinergic systems in this effect. Immunohistochemistry for choline acetyltransferase (ChAT) was used to measure the number of active cholinergic neurons in their major groups (Ch1-Ch6) and in striatal regions in rats subjected to unilateral electrocoagulation and contralateral VTA electrical stimulation (L/S group) in comparison to the unilaterally stimulated (S), unilaterally lesioned (L) and sham (Sh) groups. The study showed that unilateral VTA lesion increased (as compared to Sh group) the number of ChAT+ neurons in the Ch1-Ch3 and unilateral VTA stimulation increased the number in the Ch1 and the ventral pallidum only. The most sensitive to these changes in the mesolimbic system were cholinergic structures providing hippocampal afferentation. Surprisingly, there was no significant increase in the number of ChAT+ neurons in the L/S group. The obtained results did not confirm any evident influence of the cholinergic systems on the VTA lesion-induced facilitation of the behavioral response evoked by contralateral VTA stimulation.
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Activity in the PPTg and LDTg adapts quickly to environmental changes.
“Activity in both these areas adapts quickly to environmental changes (Majkutewicz et al., 2010; Woolf, 1991)”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Majkutewicz et al., 2010
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Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
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- Authors
- I., M., T., C., G., J., W., T., & D.*, W.
- Venue
- Acta Neurobiologiae Experimentalis
- Published
- 2010-03-31
- Volume
- 70
- Issue
- 1
- Pages
- 28-39
- ISSN
- 0065-1400 (ISSN-L)
- 1689-0035
- OpenAlex
- W2134804319
- Cited by
- 6
- References
- 54
- Citations by year
- 2024: 1 · 2019: 1 · 2016: 1 · 2012: 1
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Acta Neurobiologiae Experimentalis (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- ventral tegmental area, cholinergic neurons, choline acetyltransferase, feeding behavior, exploratory behavior, mesolimbic system, ventral pallidum, hippocampal afferents, striatum, cholinergic system
- MeSH terms
- Acetylcholine, Analysis of Variance, Animals, Behavior, Animal, Brain, Cell Count, Choline O-Acetyltransferase, Electric Stimulation, Functional Laterality, Male, Neural Pathways, Rats, Wistar, Ventral Tegmental Area, Rats
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