Cited by 6Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Lesion and stimulation of the ventral tegmental area increases cholinergic activity in the rat brain

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I., Majkutewicz, T., Cecot, G., Jerzemowska, W., Trojniar, D.*, Wrona·2010·Acta Neurobiologiae Experimentalis

Abstract

Our previous study indicated that unilateral lesion of the ventral tegmental area (VTA) facilitates contralateral VTA stimulation-induced feeding or exploration. The present study was aimed to determine the possible role of the central cholinergic systems in this effect. Immunohistochemistry for choline acetyltransferase (ChAT) was used to measure the number of active cholinergic neurons in their major groups (Ch1-Ch6) and in striatal regions in rats subjected to unilateral electrocoagulation and contralateral VTA electrical stimulation (L/S group) in comparison to the unilaterally stimulated (S), unilaterally lesioned (L) and sham (Sh) groups. The study showed that unilateral VTA lesion increased (as compared to Sh group) the number of ChAT+ neurons in the Ch1-Ch3 and unilateral VTA stimulation increased the number in the Ch1 and the ventral pallidum only. The most sensitive to these changes in the mesolimbic system were cholinergic structures providing hippocampal afferentation. Surprisingly, there was no significant increase in the number of ChAT+ neurons in the L/S group. The obtained results did not confirm any evident influence of the cholinergic systems on the VTA lesion-induced facilitation of the behavioral response evoked by contralateral VTA stimulation.

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Authors
I., M., T., C., G., J., W., T., & D.*, W.
Venue
Acta Neurobiologiae Experimentalis
Published
2010-03-31
Volume
70
Issue
1
Pages
28-39
ISSN
  • 0065-1400 (ISSN-L)
  • 1689-0035
OpenAlex
W2134804319
Cited by
6
References
54
Citations by year
2024: 1 · 2019: 1 · 2016: 1 · 2012: 1
FWCI
0.39
Type
journal article
Language
en
Open access
Locations
  • Acta Neurobiologiae Experimentalis (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
ventral tegmental area, cholinergic neurons, choline acetyltransferase, feeding behavior, exploratory behavior, mesolimbic system, ventral pallidum, hippocampal afferents, striatum, cholinergic system
MeSH terms
Acetylcholine, Analysis of Variance, Animals, Behavior, Animal, Brain, Cell Count, Choline O-Acetyltransferase, Electric Stimulation, Functional Laterality, Male, Neural Pathways, Rats, Wistar, Ventral Tegmental Area, Rats

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