Depression and anxiety in patients with multidrug-resistant tuberculosis in Nepal: an observational study
Open accessAbstract
Setting: Multidrug-resistant tuberculosis (MDR-TB) patients in the national TB treatment programme of Nepal. Objective: To estimate the prevalence of depression and anxiety in people receiving treatment for MDR-TB, identify potential risk factors for depression and anxiety and determine temporal changes in their severity during treatment. Design: An observational study using a screening tool, the Hopkins Symptom Checklist (HSCL-25) for depression and anxiety, administered monthly to a group of 135 patients in Nepal. Logistic and multilevel linear regression models were used to identify any patient characteristics associated with depression and anxiety. Results: Most of the 135 patients were male (76%) and living with their families (68%). The period prevalences of depression and anxiety were respectively 22.2% and 15.6%. Patients reporting physical side effects of MDR-TB treatment had a higher depression score on HSCL by 2.63 points (95%CI 0.77–4.48) and a 1.59 point higher anxiety score (95%CI 0.45–2.73) than those who did not report any side effects. Being single was associated with having anxiety (aOR 0.2, 95%CI 0.03–1.0). Conclusion: Given the high rates of depression observed among MDR-TB patients, national TB treatment programmes should ensure their patients are routinely screened for depression and anxiety, and effective treatment offered.
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Psychosocial problems are related to adherence to treatment programs in MDR-TB patients.
“Psychosocial problems are related to adherence to treatment programs, and thus, they affect the success and duration of the treatment program.”
From The effects of acceptance and commitment therapy on psychosocial impact and adherence of multidrug-resistant tuberculosis patients (2022) · cites this paper as [8]
Anxiety and depression contribute to non-adherence to treatment leading to poor treatment outcomes.
“Anxiety and depression contribute to non-adherence to treatment leading to poor treatment outcomes.8”
From The effects of acceptance and commitment therapy on psychosocial impact and adherence of multidrug-resistant tuberculosis patients (2022) · cites this paper as [8]
Psychosocial problems of MDR-TB patients who do not receive intervention can contribute to high dropout rates for MDR-TB treatment programs.
“Psychosocial problems of MDR-TB patients’ who do not receive intervention can contribute to high dropout rates for the following MDR-TB treatment programs. 8”
From The effects of acceptance and commitment therapy on psychosocial impact and adherence of multidrug-resistant tuberculosis patients (2022) · cites this paper as [8]
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As'hab, P. P., Keliat, B. A., & Wardani, I. Y. (2022) · Journal of Public Health Research · doi:10.4081/jphr.2021.2737 · Cited by 16 · see citing works
“Positive questions (1, 3, 5, 6, 8, 10, 13, 15, 19) answers “correct” score 0 and “wrong” score 1, negative questions (2, 4, 7, 9, 11, 12, 14, 16, 17, 18, 20) answer “correct” is worth 1 and “false” is worth 0.”
BackgroundDepression among TB patients and associated factors in Kathmandu Valley, Nepal
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- Authors
- Walker, I. F., Kanal, S., Baral, S. C., Farragher, T. M., Joshi, D., Elsey, H., & Newell, J. N.
- Affiliations
- University of Leeds (GB)
- Venue
- Public Health Action
- Published
- 2019-03
- Volume
- 9
- Issue
- 1
- Pages
- 42-48
- ISSN
- 2220-8372 (ISSN-L)
- PMC
- PMC6436490
- OpenAlex
- W2931149453
- Cited by
- 29
- References
- 18
- Citations by year
- 2026: 5 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 8 · 2020: 3 · 2019: 1
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Public Health Action (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Keywords
- multidrug-resistant tuberculosis, depression, anxiety, mental health, treatment side effects, risk factors, prevalence, single-person households, depression screening, Nepal
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