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Trace elements as an activator of antioxidant enzymes
Open accessAbstract
Oxidative stress is a state of impaired balance between the formation of free radicals and antioxidant capacity of the body. It causes many defects of the body, e.g. lipid peroxidation, DNA and protein damage. In order to prevent the effects of oxidative stress, the organism has developed defence mechanisms. These mechanisms capture and inhibit the formation of free radicals and also chelate ion metals that catalyse free radical reactions. Trace elements are components of antioxidant enzymes involved in antioxidant mechanisms. Selenium, as a selenocysteine, is a component of the active site of glutathione peroxidase (GPx). The main function of GPx is neutralization of hydrogen peroxide (H2O2) and organic peroxide (LOOH). Furthermore, selenium is a structural part of a large group of selenoproteins that are necessary for proper functioning of the body. Manganese, copper and zinc are a part of the group of superoxide dismutase enzymes (MnSOD, Cu/ZnSOD), which catalyse the superoxide anion dismutation into hydrogen peroxide and oxygen. Formed hydrogen peroxide is decomposed into water and oxygen by catalase or glutathione peroxidase. An integral component of catalase (CAT) is iron ions. The concentration of these trace elements has a significant influence on the activity of antioxidant enzymes, and thus on defence against oxidative stress. Even a small change in the level of trace elements in the tissue causes a disturbance in their metabolism, leading to the occurrence of many diseases.
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“Copper deficiency reduces the activity of the enzyme Cu/Zn-SOD and ceruloplasmin, as well as copper-independent enzymes, including catalase and glutathione peroxidase.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [127]
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Metadata
- Authors
- Wołonciej, M., Milewska, E., & Roszkowska-Jakimiec, W.
- Affiliations
- Medical University of Białystok (PL)
- Venue
- Postępy Higieny i Medycyny Doświadczalnej
- Publisher
- Walter de Gruyter GmbH
- Published
- 2016-12-31
- Volume
- 70
- Issue
- 0
- Pages
- 1483-1498
- ISSN
- 0032-5449 (ISSN-L)
- 1732-2693
- OpenAlex
- W2573113366
- Cited by
- 171
- References
- 88
- Citations by year
- 2026: 13 · 2025: 20 · 2024: 27 · 2023: 27 · 2022: 28 · 2021: 15 · 2020: 17 · 2019: 7 · 2018: 15 · 2017: 2
- FWCI
- 8.36
- Type
- journal article
- Language
- pl
- Open access
- diamond
- doi.org
- Locations
- Postępy Higieny i Medycyny Doświadczalnej (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- trace elements, antioxidant enzymes, oxidative stress, selenium, glutathione peroxidase, selenoproteins, superoxide dismutase, catalase, manganese, copper, zinc, free radicals, lipid peroxidation, metal chelation
- MeSH terms
- Superoxide Dismutase 2, Catalase, Coenzymes, Copper, Enzyme Activation, Free Radicals, Glutathione Peroxidase, Manganese, Selenium, Superoxide Dismutase, Trace Elements, Zinc, Oxidative Stress
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