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Cited by 171Trace Elements in HealthSelenium in Biological SystemsAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 41 of the 88 references it cites were found in a registry or an index.

Trace elements as an activator of antioxidant enzymes

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Wołonciej, Marta, Milewska, Elżbieta, Roszkowska-Jakimiec, Wiesława·2016·Postępy Higieny i Medycyny Doświadczalnej
DOI 10.5604/17322693.1229074
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Abstract

Oxidative stress is a state of impaired balance between the formation of free radicals and antioxidant capacity of the body. It causes many defects of the body, e.g. lipid peroxidation, DNA and protein damage. In order to prevent the effects of oxidative stress, the organism has developed defence mechanisms. These mechanisms capture and inhibit the formation of free radicals and also chelate ion metals that catalyse free radical reactions. Trace elements are components of antioxidant enzymes involved in antioxidant mechanisms. Selenium, as a selenocysteine, is a component of the active site of glutathione peroxidase (GPx). The main function of GPx is neutralization of hydrogen peroxide (H2O2) and organic peroxide (LOOH). Furthermore, selenium is a structural part of a large group of selenoproteins that are necessary for proper functioning of the body. Manganese, copper and zinc are a part of the group of superoxide dismutase enzymes (MnSOD, Cu/ZnSOD), which catalyse the superoxide anion dismutation into hydrogen peroxide and oxygen. Formed hydrogen peroxide is decomposed into water and oxygen by catalase or glutathione peroxidase. An integral component of catalase (CAT) is iron ions. The concentration of these trace elements has a significant influence on the activity of antioxidant enzymes, and thus on defence against oxidative stress. Even a small change in the level of trace elements in the tissue causes a disturbance in their metabolism, leading to the occurrence of many diseases.

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Metadata

Authors
Wołonciej, M., Milewska, E., & Roszkowska-Jakimiec, W.
Affiliations
Medical University of Białystok (PL)
ORCID
Venue
Postępy Higieny i Medycyny Doświadczalnej
Publisher
Walter de Gruyter GmbH
Published
2016-12-31
Volume
70
Issue
0
Pages
1483-1498
ISSN
  • 0032-5449 (ISSN-L)
  • 1732-2693
DOI
10.5604/17322693.1229074
OpenAlex
W2573113366
Cited by
171
References
88
Citations by year
2026: 13 · 2025: 20 · 2024: 27 · 2023: 27 · 2022: 28 · 2021: 15 · 2020: 17 · 2019: 7 · 2018: 15 · 2017: 2
FWCI
8.36
Type
journal article
Language
pl
Open access
Locations
  • Postępy Higieny i Medycyny Doświadczalnej (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords
trace elements, antioxidant enzymes, oxidative stress, selenium, glutathione peroxidase, selenoproteins, superoxide dismutase, catalase, manganese, copper, zinc, free radicals, lipid peroxidation, metal chelation
MeSH terms
Superoxide Dismutase 2, Catalase, Coenzymes, Copper, Enzyme Activation, Free Radicals, Glutathione Peroxidase, Manganese, Selenium, Superoxide Dismutase, Trace Elements, Zinc, Oxidative Stress

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