The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Plasma C-Reactive Protein in Nonobese Children With Obstructive Sleep Apnea Before and After Adenotonsillectomy
Open accessAbstract
Study objective Sleep-disordered breathing (SDB) is a prevalent condition in children and is associated with increased cardiovascular morbidity. Circulating levels of C-reactive protein (CRP), a proinflammatory protein, are associated with increased risk for atherosclerosis. Plasma CRP levels in snoring children have yielded conflicting results, such that it remains unclear whether OSA is mechanistically involved in such elevations of CRP.Methods Consecutive nonobese children with polysomnographically demonstrated obstructive sleep apnea underwent blood draws in the morning after their corresponding sleep studies on 2 occasions, namely at diagnosis of obstructive sleep apnea and 10 to 14 weeks after adenotonsillectomy. High-sensitivity CRP serum concentrations were determined within 2 to 3 hours after collection, using a particle-enhanced turbidimetric immunoassay technique.Results Twenty children with obstructive sleep apnea (mean age 7.3 +/- 1.9 years; 55% boys; relative body mass index: 88% +/- 12.0%) with a mean apnea-hypopnea index at diagnosis of 15.6 +/- 2.9 events per hour of total sleep time and nadir SaO2 of 82.3% +/- 2.5% were included. Mean initial CRP levels at obstructive sleep apnea diagnosis were 0.67 +/- 0.21 mg/dL and decreased to 0.23 +/- 0.07 mg/dL after adenotonsillectomy (p < .05), along with significant decreases in measured apnea-hypopnea index (2.2 +/- 0.8 events/h of total sleep time; p < .01) and improved oxygenation (mean nadir SaO2 values: 88.6% +/- 1.9%; p < .01).Conclusions Obstructive sleep apnea is frequently associated with increases in CRP levels that are reversible upon treatment. Thus, obstructive sleep apnea induces a systemic inflammatory response in children, which, if left untreated, may potentially lead to cardiovascular morbidity.
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“The underlying pathophysiologic effects of sleep-disordered breathing that may cause these deleterious effects include endothelial dysfunction (200), autonomic dysfunction (201), and chronic inflammation (202).”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [202]
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“The underlying pathophysiologic effects of sleep-disordered breathing that may cause these deleterious effects include endothelial dysfunction (200), autonomic dysfunction (201), and chronic inflammation (202).”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [200]
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Pediatric Obstructive Sleep Apnea: Complications, Management, and Long-term Outcomes
Capdevila, Ó. S., Gozal, D., Dayyat, E. A., & Gozal, D. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200708-138mg · Cited by 445
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Cardiovascular Morbidity in Obstructive Sleep Apnea
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Obstructive sleep apnea in children: a critical update
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C-reactive Protein, Obstructive Sleep Apnea, and Cognitive Dysfunction in School-aged Children
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Metadata
- Authors
- Kheirandish-Gozal, L., Capdevila, O. S., Tauman, R., & Gozal, D.
- Affiliations
- University of Louisville (US)
- ORCID
- Tauman, Riva
- Venue
- Journal of Clinical Sleep Medicine
- Published
- 2006-07-15
- Volume
- 2
- Issue
- 3
- Pages
- 301-304
- ISSN
- 1550-9389 (ISSN-L)
- 1550-9397
- PMC
- PMC1847566
- OpenAlex
- W2157655916
- Cited by
- 160
- References
- 40
- Citations by year
- 2025: 1 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 12 · 2015: 6 · 2014: 11 · 2013: 14 · 2012: 13
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-65 270, R01HL065270)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- obstructive sleep apnea, C-reactive protein, adenotonsillectomy, sleep-disordered breathing, systemic inflammation, children, apnea-hypopnea index, oxygenation, cardiovascular risk, snoring
- MeSH terms
- Adenoidectomy, C-Reactive Protein, Child, Female, Humans, Male, Obesity, Postoperative Care, Preoperative Care, Sleep Apnea Syndromes, Sleep, REM, Tonsillectomy, Polysomnography, Sleep Apnea, Obstructive
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