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Cited by 160Obstructive Sleep Apnea ResearchAdipokines, Inflammation, and Metabolic DiseasesSleep and related disorders

The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.

Plasma C-Reactive Protein in Nonobese Children With Obstructive Sleep Apnea Before and After Adenotonsillectomy

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Kheirandish-Gozal, Leila, Capdevila, Oscar Sans, Tauman, Riva, Gozal, David·2006·Journal of Clinical Sleep Medicine
DOI 10.5664/jcsm.26589PMC PMC1847566
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Abstract

Study objective Sleep-disordered breathing (SDB) is a prevalent condition in children and is associated with increased cardiovascular morbidity. Circulating levels of C-reactive protein (CRP), a proinflammatory protein, are associated with increased risk for atherosclerosis. Plasma CRP levels in snoring children have yielded conflicting results, such that it remains unclear whether OSA is mechanistically involved in such elevations of CRP.Methods Consecutive nonobese children with polysomnographically demonstrated obstructive sleep apnea underwent blood draws in the morning after their corresponding sleep studies on 2 occasions, namely at diagnosis of obstructive sleep apnea and 10 to 14 weeks after adenotonsillectomy. High-sensitivity CRP serum concentrations were determined within 2 to 3 hours after collection, using a particle-enhanced turbidimetric immunoassay technique.Results Twenty children with obstructive sleep apnea (mean age 7.3 +/- 1.9 years; 55% boys; relative body mass index: 88% +/- 12.0%) with a mean apnea-hypopnea index at diagnosis of 15.6 +/- 2.9 events per hour of total sleep time and nadir SaO2 of 82.3% +/- 2.5% were included. Mean initial CRP levels at obstructive sleep apnea diagnosis were 0.67 +/- 0.21 mg/dL and decreased to 0.23 +/- 0.07 mg/dL after adenotonsillectomy (p < .05), along with significant decreases in measured apnea-hypopnea index (2.2 +/- 0.8 events/h of total sleep time; p < .01) and improved oxygenation (mean nadir SaO2 values: 88.6% +/- 1.9%; p < .01).Conclusions Obstructive sleep apnea is frequently associated with increases in CRP levels that are reversible upon treatment. Thus, obstructive sleep apnea induces a systemic inflammatory response in children, which, if left untreated, may potentially lead to cardiovascular morbidity.

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  3. [37]Chin K, Nakamura T, Shimizu K, et al. Effects of nasal continuous positive airway pressure on soluble cell adhesion molecules in patients with obstructive sleep apnea syndrome. Am J Med. 2000;109:562–7. doi: 10.1016/s0002-9343(00)00580-5. [[DOI](https://doi.org/10.1016/s0002-9343(00)00580-5)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/11063958/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Am%20J%20Med&title=Effects%20of%20nasal%20continuous%20positive%20airway%20pressure%20on%20soluble%20cell%20adhesion%20molecules%20in%20patients%20with%20obstructive%20sleep%20apnea%20syndrome&author=K%20Chin&author=T%20Nakamura&author=K%20Shimizu&volume=109&publication_year=2000&pages=562-7&pmid=11063958&doi=10.1016/s0002-9343(00)00580-5&)] · DOI · Paper page

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Metadata

Authors
Kheirandish-Gozal, L., Capdevila, O. S., Tauman, R., & Gozal, D.
Affiliations
University of Louisville (US)
ORCID
Tauman, Riva
Venue
Journal of Clinical Sleep Medicine
Publisher
Springer Science and Business Media LLC
Published
2006-07-15
Volume
2
Issue
3
Pages
301-304
ISSN
  • 1550-9389 (ISSN-L)
  • 1550-9397
DOI
10.5664/jcsm.26589
PMC
PMC1847566
OpenAlex
W2157655916
Cited by
160
References
40
Citations by year
2025: 1 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 12 · 2015: 6 · 2014: 11 · 2013: 14 · 2012: 13
FWCI
7.73
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Clinical Sleep Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (HL-65 270, R01HL065270)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
obstructive sleep apnea, C-reactive protein, adenotonsillectomy, sleep-disordered breathing, systemic inflammation, children, apnea-hypopnea index, oxygenation, cardiovascular risk, snoring
MeSH terms
Adenoidectomy, C-Reactive Protein, Child, Female, Humans, Male, Obesity, Postoperative Care, Preoperative Care, Sleep Apnea Syndromes, Sleep, REM, Tonsillectomy, Polysomnography, Sleep Apnea, Obstructive

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