Sleep Apnea Cardiovascular Clinical Trials—Current Status and Steps Forward: The International Collaboration of Sleep Apnea Cardiovascular Trialists
Open accessAbstract
Sleep apnea is a common chronic disease that is associated with coronary heart disease, stroke, heart failure and mortality, although the ability of sleep apnea treatment to reduce cardiovascular morbidity and mortality has not been demonstrated. In contrast to patients seeking treatment in sleep disorders centers, as many as half of individuals with moderate to severe sleep apnea in the general population do not report excessive sleepiness; however, if treatment of sleep apnea were shown to reduce cardiovascular disease risk, this would provide a strong rationale for treatment of sleep apnea even in the absence of daytime sleepiness. This article summarizes the status of clinical trials evaluating the potential cardiovascular benefits of sleep apnea treatment and discusses the challenges of conducting such trials, and introduces the International Collaboration of Sleep Apnea Cardiovascular Trialists (INCOSACT), a clinical research collaboration formed to foster cardiovascular sleep research. CITATION: 2013;36(7):975-980.
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Regarding sleep apnoea, there are several studies that have shown improvements in cardiovascular outcomes.
“Regarding sleep apnoea, there are several studies that have shown improvements in cardiovascular outcomes (Gottlieb et al., 2013).”
From Addressing sleep disturbances: an opportunity to prevent cardiometabolic disease? (2014) · cites this paper as Gottlieb et al., 2013
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- Authors
- Gottlieb, D. J., Craig, S. E., Lorenzi-Filho, G., Heeley, E., Redline, S., McEvoy, R. D., & Durán-Cantolla, J.
- Affiliations
- Brigham and Women's Hospital (US)
- Churchill Hospital (GB)
- Sleep Laboratory, Pulmonary Division - Heart Institute (InCor), University of São Paulo, Brazil
- The University of Sydney (AU)
- Flinders University (AU)
- Bio-Araba Research Institute and Sleep Unit of Alava University Hospital, Department of Medicine of Basque Country University, Vitoria-Gasteiz, Spain
- Corresponding author
- Gottlieb, Daniel J.
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-07-01
- Volume
- 36
- Issue
- 7
- Pages
- 975-980
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC3669073
- OpenAlex
- W2064498957
- Cited by
- 30
- References
- 36
- Citations by year
- 2022: 3 · 2020: 2 · 2018: 2 · 2017: 2 · 2016: 7 · 2015: 4 · 2014: 10
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- SLEEP (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Flinders Academic Commons (Flinders University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
- Keywords
- sleep apnea, cardiovascular disease, sleep apnea treatment, cardiovascular risk reduction, clinical trials, coronary artery disease, stroke, heart failure, mortality, excessive daytime sleepiness
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