Antihypertensive Peptides Specific to Lactobacillus helveticus Fermented Milk
Open accessAbstract
SBP (mm Hg) <Enzymatic hydrolysate> FFVAPFPEVFGK s1-casein Trypsin 77 100 -13.0 AVPYPQR β-casein Trypsin 15 100 -10.0 TTMPLW s1-casein Trypsin 16 100 -13.6 LKPNM Aldolase Thermolysin 2.4 60 -23 LKP Aldolase Chicken muscle 0.32 60 -18 IPA β-lactogloblin Proteinase K 141 8 -31 VYPFPG β-casein Proteinase K 221 8 -22 GKP β-microglobulin Proteinase K 352 8 -26 FP β-casein, albumin Proteinase K 315 8 -27 YKVPQL s1-casein Proteinase 22 1 -12.5 <Fermented products> RF Sake lees Brewing ND 100 -17 VW Sake lees Brewing 1.4 100 -10 YW Sake lees Brewing 10.5 100 -28 VY Sake Brewing 7.1 100 -31 IYPRY Sake Brewing 4.1 100 -19 VPP β-casein Fermentation 9 1.6 -20 IPP βand κ -casein Fermentation 5 1 -15.1 YP s1, βand κ-casein Fermentation 720 1 -27.4ND: Not described * IC50: Peptide concentration that shows 50% inhibition of ACE activity * * * SBP: systolic blood pressure of spontaneously hypertensive rat * ACEI activity: Peptides that show 50% inhibition of ACE activity was defined as one unit.
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When milk is used as a growth media for LAB, their proteolytic system is activated.
“It is well known that when milk is used as a growth media for LAB, their proteolytic system is activated (Wakai and Yamamoto, 2012).”
From Lactobacillus helveticus: the proteolytic system (2013) · cites this paper as Wakai and Yamamoto, 2012
Cites
Yamamoto, N., Akino, A., & Takano, T. (1994) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(94)77026-0 · Cited by 418 · see citing works
Self-citationMeisel, H., & Bockelmann, W. (1999) · Antonie van Leeuwenhoek · doi:10.1023/a:1002063805780 · Cited by 284 · see citing works
Yamamoto, N., Maeno, M., & Takano, T. (1999) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(99)75364-6 · Cited by 266 · see citing works
Self-citationGenay, M., Sadat, L., Gagnaire, V., & Lortal, S. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02395-08 · Cited by 66 · see citing works
Ueno, K., Mizuno, S., & Yamamoto, N. (2004) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2004.01560.x · Cited by 46 · see citing works
Self-citationYAMAMOTO, N., ONO, H., MAENO, M., UEDA, Y., TAKANO, T., & MOMOSE, H. (1998) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.62.1228 · Cited by 17 · see citing works
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Health benefits of fermented foods
Şanlier, N., Gökcen, B. B., & Sezgin, A. C. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1383355 · Cited by 789 · see citing works
Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines
Pessione, E., & Cirrincione, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00876 · Cited by 333 · see citing works
Lactobacillus helveticus: the proteolytic system
Griffiths, M. W., & Tellez, A. M. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00030 · Cited by 241 · see citing works
“helveticus to produce antihypertensive peptides has been attributed to the CEP (Ono et al., 1997; Wakai and Yamamoto, 2012).”
BackgroundInfluential
- Authors
- Wakai, T., & Yamamoto, N.
- Affiliations
- Calpis Co., Ltd. (Japan) (JP)
- Corresponding author
- Wakai, Taketo
- ORCID
- Yamamoto, Naoyuki
- Venue
- Biotechnology - Molecular Studies and Novel Applications for Improved Quality of Human Life
- Publisher
- InTech
- Published
- 2012-03-14
- OpenAlex
- W1489000026
- Cited by
- 36
- References
- 6
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 2
- FWCI
- 2.73
- Type
- book chapter
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- InTech eBooks (publishedVersion, cc-by)
- BiblioBoard Library Catalog (Open Research Library) (submittedVersion, cc-by)
- Contact-less Assessment of In-vivo Body Signals Using Microwave Doppler Radar (InTech) (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Keywords
- antihypertensive peptides, Lactobacillus helveticus, fermented milk, angiotensin-converting enzyme inhibition, casein peptides, β-casein, αs1-casein, β-lactoglobulin, spontaneously hypertensive rats, blood pressure
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