Reactive Oxygen Species (ROS) in Living Cells
Open accessAbstract
Oxygen represents only 20% of the Earth's atmosphere, yet it is vital for the survival of aerobic organisms. There is a dark part of the use of oxygen that consists in generating reactive species that are potentially harmful to living organisms. Moreover, reactive oxygen species can combine with nitrogen derivatives and generate many other reactive species. Thus, living organisms are continuously assaulted by reactive species from external or internal sources. However, the real danger comes in the case of high concentrations and prolonged exposure to these species. This book presents an image of the mechanisms of action of reactive species and emphasizes their involvement in diseases. Inflammation and cancer are examined to determine when and how reactive species turn the evolution of a benign process to a malignant one. Some answers may come from recent studies indicating that reactive species are responsible for epigenetic changes.
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RANKL-induced ROS production stimulates the activation of the Akt, NF-κB, and extracellular-signal-regulated kinase pathways in osteoclasts, which leads to increased bone resorption activity.
“RANKL-induced ROS production stimulates the activation of the Akt, NF-κB, and extracellular-signal-regulated kinase pathways in osteoclasts, which leads to increased bone resorption activity87,88.”
ROS acts as a second messenger during receptor activator of NF-κB ligand (RANKL) differentiation and activation.
“Additionally, ROS acts as a second messenger during receptor activator of NF-κB ligand (RANKL) differentiation and activation.”
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- Authors
- Filip, C., & Albu, E.
- Venue
- InTech eBooks
- Publisher
- InTech
- Published
- 2018-05-23
- OpenAlex
- W2887203428
- Cited by
- 70
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 8 · 2023: 15 · 2022: 17 · 2021: 12 · 2020: 11 · 2019: 2 · 2018: 2
- FWCI
- 6.92
- Type
- book
- Language
- en
- Open access
- green
- www.intechopen.com
- Licence
- cc-by
- Locations
- InTech eBooks (publishedVersion)
- Directory of Open access Books (OAPEN Foundation) (submittedVersion)
- Funders
- Alexander von Humboldt-Stiftung
- Chulalongkorn University
- Government of Jiangsu Province
- Thailand Research Fund
- National Research Council of Thailand
- Novartis Pharma
- Japan Society for the Promotion of Science (16K15604)
- Japan Science and Technology Agency
- Faculty of Medicine, Chulalongkorn University
- Science and Technology Research Partnership for Sustainable Development
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- reactive oxygen species, reactive nitrogen species, oxidative stress, inflammation, cancer, epigenetic modifications, aerobic metabolism
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