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Comparison of Two Meta-Analysis Methods: Inverse-Variance-Weighted Average and Weighted Sum of Z-Scores
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Meta-analysis of discovery and Ji County data showed consistent directions of effect: β = 24.82, SE = 4.80, P = 2.29x10-7 by inverse-variance-weighted method, and P = 7.03x10-8 by weighted sum of Z-scores.
“Meta-analysis of discovery stage and Ji County data showed consistent directions of effect: β = 24.82, SE = 4.80, P = 2.29x10-7 utilizing inverse-variance-weighted method, and P = 7.03x10-8 by employing a weighted sum of Z-scores method [35].”
From Genetic variation in CCDC93 is associated with elevated central systolic blood pressure, impaired arterial relaxation, and mitochondrial dysfunction (2024) · cites this paper as [35]
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“…effects and assess robustness to potential assumption violations, particularly horizontal pleiotropy (violation of assumption 3), five complementary MR methods were applied, including inverse-variance weighted (IVW), weighted median, weighted mode, simple mode, and MR-Egger regression[30 – 32].”
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Metadata
- Authors
- Lee, C. H., Cook, S., Lee, J. S., & Han, B.
- Affiliations
- Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.
- Venue
- Genomics & Informatics
- Publisher
- Korea Genome Organization
- Published
- 2016
- Volume
- 14
- Issue
- 4
- Pages
- 173
- ISSN
- 2234-0742
- PMC
- PMC5287121
- Cited by
- 308
- References
- 11
- Language
- en
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