The DOI matches its Crossref record, with a small difference in title or year; 1 of the 1 references it cites were found in a registry or an index.
Transplant of Hepatocytes, Undifferentiated Mesenchymal Stem Cells, and In Vitro Hepatocyte-Differentiated Mesenchymal Stem Cells in a Chronic Liver Failure Experimental Model: A Comparative Study.
Abstract
OBJECTIVES: Liver transplant is the cornerstone line of treatment for chronic liver diseases; however, the long list of complications and obstacles stand against this operation. Searching for new modalities for treatment of chronic liver illness is a must. In the present research, we aimed to compare the effects of transplant of undifferentiated human mesenchymal stem cells, in vitro differentiated mesenchymal stem cells, and adult hepatocytes in an experimental model of chronic liver failure. MATERIALS AND METHODS: Undifferentiated human cord blood mesenchymal stem cells were isolated, pro-pagated, and characterized by morphology, gene expression analysis, and flow cytometry of surface markers and in vitro differentiated into hepatocyte-like cells. Rat hepatocytes were isolated by double perfusion technique. An animal model of chronic liver failure was developed, and undifferentiated human cord blood mesenchymal stem cells, in vitro hepato-genically differentiated mesenchymal stem cells, or freshly isolated rat hepatocytes were transplanted into a CCL4 cirrhotic experimental model. Animals were killed 3 months after transplant, and liver functions and histopathology were assessed. RESULTS: Compared with the cirrhotic control group, the 3 cell-treated groups showed improved alanine aminotransferase, aspartate aminotransferase, albumin, and bilirubin levels, with best results shown in the hepatocyte-treated group. Histopathologic examination of the treated groups showed improved fibrosis, with best results obtained in the undifferentiated mesenchymal stem cell-treated group. CONCLUSIONS: Both adult hepatocytes and cord blood mesenchymal stem cells proved to be promising candidates for cell-based therapy in liver regeneration on an experimental level. Improved liver function was evident in the hepatocyte-treated group, and fibrosis control was more evident in the undifferentiated mesenchymal stem cell-treated group.
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“Nevertheless, unlike findings from animal experiments, human studies did not show favorable results regarding liver function, fibrosis, or survival rates [37–39].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [37]
In the citing paper
“In a CCl4-induced liver fibrosis model, the undifferentiated MSC-treated group had better outcomes in liver function test and fibrosis control [37].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [37]
In the citing paper
“However, animal experiments provided conflicting findings regarding the therapeutic effects of differentiated and undifferentiated MSCs [37, 306].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [37]
Citations
Cites
Human hepatocyte transplantation: current experience and future challenges
Dhawan, A., Puppi, J., Hughes, R. D., & Mitry, R. R. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.44 · Cited by 362
Research works printed but not linked: 38
- 10.1016/j.transproceed.2014.07.023 · DOI
- 10.1111/hepr.12265 · DOI
- 3. Moharib M, Hammam O, Salman F, El-naggar M, Sherif S. Transplantation of modified and fresh hepatocyte reduces hepatotoxicity induced by carbon tetrachloride. Life Sci J. 2014;11:641-652.
- 10.1007/s00534-008-0023-0 · DOI
- 10.1097/TP.0000000000000463 · DOI
- 10.1053/gast.2003.50065 · DOI
- 10.1016/j.jhep.2010.05.010 · DOI
- 10.1111/j.1600-6143.2007.02058.x · DOI
- 10.3748/wjg.14.4593 · DOI
- 11. Larijani B, Esfahani EN, Amini P, et al. Stem cell therapy in treatment of different diseases. Acta Med Iran. 2012;50(2):79-96.
- 10.2174/157488809788167418 · DOI
- 10.1172/JCI43267 · DOI
- 14. Lazebnik LB, Golovanova EV, Slupskaia VA, Trubitsina IE, Kniazev OV, Shaposhnikova NA. Realities and prospects for the use of cell technologies for the treatment of chronic diffuse liver diseases [in Russian]. Eksp Klin Gastroenterol. 2011(6):3-10.
- 10.1016/j.scr.2013.08.011 · DOI
- 10.1089/scd.1.1996.5.105 · DOI
- 17. Litwin J. Standardization of human diploid fibroblast cultivation: trypsinization procedure. Appl Microbiol. 1971;21(2):169-174. · DOI
- 10.1177/29.4.6166661 · DOI
- 10.1016/j.bej.2005.02.028 · DOI
- 20. Gewartowska M, Olszewski WL. Hepatocyte transplantation-biology and application. Ann Transplant. 2007;12(1):27-36.
- 10.1084/jem.20040440 · DOI
- 10.1002/hep.20469 · DOI · Paper page
- 10.1016/j.cellbi.2007.08.002 · DOI
- 10.4172/2329-8820.1000137 · DOI
- 10.1634/stemcells.2004-0024 · DOI
- 10.1007/978-1-60761-369-5_23 · DOI
- 27. Hua J, Qiu P, Zhu H. Multipotent mesenchymal stem cells (MSCs) from human umbilical cord: Potential differentiation of germ cells. African J Biochem Res. 2011;5:113-123.
- 10.1089/scd.2005.14.643 · DOI
- 10.1159/000187716 · DOI
- 10.5455/jppa.20150131065107 · DOI
- 10.1631/jzus.B1300081 · DOI
- 10.1007/s12015-010-9126-5 · DOI
- 10.1002/hep.25817 · DOI
- 10.1186/1479-5876-11-78 · DOI
- 10.1186/s12876-014-0198-6 · DOI
- 10.1016/j.jhep.2014.10.030 · DOI · Paper page
- 10.1002/hep.26470 · DOI
- 10.1681/ASN.2005050544 · DOI
- 40. Badrawy T, El Sharawy S, Zalata K. The value of hepatocyte transplantation in the problem of acute liver failure in rats. Egypt J Surg. 2002;21:812-819. · DOI
Cited by
Sorted by citations
Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment
Yang, X., Li, Q., Liu, W., Zong, C., Wei, L., Shi, Y., & Han, Z. (2023) · Cellular & Molecular Immunology · doi:10.1038/s41423-023-00983-5 · Cited by 120
Pan, X., Gao, T., & Wang, B. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01520-9 · Cited by 2
“However, animal experiments provided conflicting findings regarding the therapeutic effects of differentiated and undifferentiated MSCs [37, 306].”
Metadata
- Authors
- Baz, H. E., Demerdash, Z. A., Kamel, M. M., Atta, S. A., Salah, F., Hassan, S., Hammam, O. A., Khalil, H. M. A., Meshaal, S. S., & Raafat, I. I.
- Affiliations
- Theodor Bilharz Research Institute (EG)
- Venue
- Experimental and Clinical Transplantation
- Publisher
- Baskent University
- Published
- 2018-02
- Volume
- 16
- Issue
- 1
- Pages
- 81-89
- ISSN
- 1304-0855 (ISSN-L)
- 2146-8427
- OpenAlex
- W3022572308
- Cited by
- 14
- References
- 1
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 1
- Type
- paratext
- Language
- en
- Open access
- closed
- Locations
- Experimental and Clinical Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- mesenchymal stem cells, hepatocyte transplantation, chronic liver failure, liver cirrhosis, carbon tetrachloride-induced liver injury, liver regeneration, liver fibrosis, cell therapy, cord blood stem cells, rat model
- MeSH terms
- Animals, Carbon Tetrachloride, Cell Differentiation, Cells, Cultured, Humans, Liver Cirrhosis, Experimental, Liver Regeneration, Male, Mice, Inbred BALB C, Phenotype, Rats, Inbred Lew, Time Factors, Biomarkers, Liver Transplantation, Recovery of Function, Hepatocytes, Cord Blood Stem Cell Transplantation, Mesenchymal Stem Cell Transplantation, Chemical and Drug Induced Liver Injury, End Stage Liver Disease, Mesenchymal Stem Cells
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- CoChat. (2026). Citation check: Transplant of Hepatocytes, Undifferentiated Mesenchymal Stem Cells, and In Vitro Hepatocyte-Differentiated Mesenchymal Stem Cells in a Chronic Liver Failure Experimental Model: A Comparative Study. https://app.cochat.ai/papers/10.6002/ect.2016.0226
- The paper
- Baz, H. E., Demerdash, Z. A., Kamel, M. M., Atta, S. A., Salah, F., Hassan, S., Hammam, O. A., Khalil, H. M. A., Meshaal, S. S., & Raafat, I. I. (2017). Transplant of Hepatocytes, Undifferentiated Mesenchymal Stem Cells, and In Vitro Hepatocyte-Differentiated Mesenchymal Stem Cells in a Chronic Liver Failure Experimental Model: A Comparative Study. Experimental and Clinical Transplantation. https://doi.org/10.6002/ect.2016.0226
