Cited by 365Organ Transplantation Techniques and OutcomesLiver physiology and pathologyTissue Engineering and Regenerative Medicine

Human hepatocyte transplantation: current experience and future challenges

Dhawan, Anil, Puppi, Juliana, Hughes, Robin D., Mitry, Ragai R.·2010·Nature Reviews Gastroenterology & Hepatology

Abstract

Hepatocyte transplantation has shown potential as an additional treatment modality for certain diseases of the liver. To date, patients with liver-based metabolic disorders or acute liver failure have undergone hepatocyte transplantation in several centers around the world. Results from individual patients are promising, especially for the treatment of liver-based metabolic disorders, but the lack of controlled trials makes the interpretation of the findings difficult. The current source of isolated hepatocytes is donor organs that are unused or deemed unsuitable for liver transplantation. Hence the major challenge that this field is facing is the limited supply of donor organs that can provide good quality cells. Alternative sources of cells, including stem cells, are under investigation. This Review discusses the current bench-to-bedside issues and future challenges that need to be faced to allow the wider application of hepatocyte transplantation.

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Crossref · 10.1038/nrgastro.2010.44

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Authors
Dhawan, A., Puppi, J., Hughes, R. D., & Mitry, R. R.
Affiliations
  • King's College Hospital (GB)
  • King's College London (GB)
Corresponding author
Dhawan, Anil
Venue
Nature Reviews Gastroenterology & Hepatology
Published
2010-04-06
Volume
7
Issue
5
Pages
288-298
ISSN
  • 1759-5045 (ISSN-L)
  • 1759-5053
OpenAlex
W1999889167
Cited by
362
References
117
Citations by year
2026: 5 · 2025: 11 · 2024: 21 · 2023: 21 · 2022: 22 · 2021: 13 · 2020: 29 · 2019: 31 · 2018: 39 · 2017: 20 · 2016: 18 · 2015: 29 · 2014: 30 · 2013: 29 · 2012: 28
FWCI
4.15
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Gastroenterology & Hepatology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
hepatocyte transplantation, metabolic liver disease, acute liver failure, organ shortage, stem cell sources, cell therapy, bench-to-bedside translation
MeSH terms
Animals, Humans, Treatment Outcome, Liver Failure, Cell Transplantation, Hepatocytes

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