Human hepatocyte transplantation: current experience and future challenges
Abstract
Hepatocyte transplantation has shown potential as an additional treatment modality for certain diseases of the liver. To date, patients with liver-based metabolic disorders or acute liver failure have undergone hepatocyte transplantation in several centers around the world. Results from individual patients are promising, especially for the treatment of liver-based metabolic disorders, but the lack of controlled trials makes the interpretation of the findings difficult. The current source of isolated hepatocytes is donor organs that are unused or deemed unsuitable for liver transplantation. Hence the major challenge that this field is facing is the limited supply of donor organs that can provide good quality cells. Alternative sources of cells, including stem cells, are under investigation. This Review discusses the current bench-to-bedside issues and future challenges that need to be faced to allow the wider application of hepatocyte transplantation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Transplantation of primary hepatocytes has been evaluated as an alternative to organ transplantation both in clinics and animal models.
“Transplantation of primary hepatocytes has been evaluated as an alternative to organ transplantation both in clinics and animal models (Dhawan et al., 2010”
From In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity (2018) · cites this paper as Dhawan et al., 2010
For late-stage liver diseases in which the liver loses its regeneration capability, the only curative therapy is liver transplantation.
“For late-stage liver diseases in which the liver loses its regeneration capability, the only curative therapy is liver transplantation (Dhawan et al., 2010”
From In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity (2018) · cites this paper as Dhawan et al., 2010
About 10% of liver cells must be replaced to have therapeutic effect on human patients.
“Because about 10% of liver cells must be replaced to have therapeutic effect on human patients (Dhawan et al., 2010”
From In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity (2018) · cites this paper as Dhawan et al., 2010
For some liver diseases, a repopulation of 10% would be sufficient to show a therapeutic effect.
“Because for some liver diseases a repopulation of 10% would be sufficient to show therapeutic effect (Dhawan et al., 2010”
From In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity (2018) · cites this paper as Dhawan et al., 2010
Cites
Bone Marrow as a Potential Source of Hepatic Oval Cells
Petersen, B. E., Bowen, W. C., Patrene, K. D., Mars, W. M., Sullivan, A. K., Murase, N., Boggs, S. S., Greenberger, J. S., & Goff, J. P. (1999) · Science · doi:10.1126/science.284.5417.1168 · Cited by 2,377 · see citing works
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
Terada, N., Hamazaki, T., Oka, M., Hoki, M., Mastalerz, D. M., Nakano, Y., Meyer, E. M., Morel, L. M., Petersen, B. E., & Scott, E. W. (2002) · Nature · doi:10.1038/nature730 · Cited by 2,000 · see citing works
Cell fusion is the principal source of bone-marrow-derived hepatocytes
Wang, X., Willenbring, H., Akkari, Y. M. N., Torimaru, Y., Foster, M., Al-Dhalimy, M., Lagasse, E., Finegold, M. J., Olson, S. B., & Grompe, M. (2003) · Nature · doi:10.1038/nature01531 · Cited by 1,569 · see citing works
Iron oxide MR contrast agents for molecular and cellular imaging
Bulte, J. W. M., & Kraitchman, D. L. (2004) · NMR in Biomedicine · doi:10.1002/nbm.924 · Cited by 1,500 · see citing works
Liver from bone marrow in humans
Theise, N. D., Nimmakayalu, M., Gardner, R., Illei, P. B., Morgan, G., Teperman, L., Henegariu, O., & Krause, D. S. (2000) · Hepatology · doi:10.1053/jhep.2000.9124 · Cited by 1,210 · see citing works
Production of α1,3-Galactosyltransferase-Deficient Pigs
Phelps, C. J., Koike, C., Vaught, T. D., Boone, J. T., Wells, K. D., Chen, S.-H., Ball, S. F., Specht, S. M., Polejaeva, I. A., Monahan, J. A., et al. (2003) · Science · doi:10.1126/science.1078942 · Cited by 1,111 · see citing works
Treatment of the Crigler–Najjar Syndrome Type I with Hepatocyte Transplantation
Fox, I. J., Chowdhury, J. R., Kaufman, S. S., Goertzen, T. C., Chowdhury, N. R., Warkentin, P. I., Dorko, K., Sauter, B. V., & Strom, S. C. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805143382004 · Cited by 1,022 · see citing works
Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice
Azuma, H., Paulk, N., Ranade, A., Dorrell, C., Al-Dhalimy, M., Ellis, E., Strom, S., Kay, M. A., Finegold, M., & Grompe, M. (2007) · Nature Biotechnology · doi:10.1038/nbt1326 · Cited by 835 · see citing works
Roskams, T., Theise, N. D., Balabaud, C. P., Bhagat, G., Bhathal, P. S., Bioulac‐Sage, P., Brunt, E. M., Crawford, J. M., Crosby, H. A., Desmet, V. J., et al. (2004) · Hepatology · doi:10.1002/hep.20130 · Cited by 729 · see citing works
Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells
Fausto, N. (2004) · Hepatology · doi:10.1002/hep.20214 · Cited by 720 · see citing works
Yamada, K., Yazawa, K., Shimizu, A., Iwanaga, T., Hisashi, Y., Nuhn, M. G., O'Malley, P., Nobori, S., Vagefi, P. A., Patience, C., et al. (2004) · Nature Medicine · doi:10.1038/nm1172 · Cited by 609 · see citing works
Glucose-6-Phosphatase of the Liver in Glycogen Storage Disease
Cori, G. T., & Cori, C. F. (1952) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38504-1 · Cited by 601 · see citing works
Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes.
Overturf, K., Al-Dhalimy, M., Ou, C. N., Finegold, M. J., & Grompe, M. (1997) · Europe PMC (PubMed Central) · Cited by 599 · see citing works
Replacement of Diseased Mouse Liver by Hepatic Cell Transplantation
Rhim, J. A., Sandgren, E. P., Degen, J. L., Palmiter, R. D., & Brinster, R. L. (1994) · Science · doi:10.1126/science.8108734 · Cited by 577 · see citing works
Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes
Banas, A., Teratani, T., Yamamoto, Y., Tokuhara, M., Takeshita, F., Quinn, G., Okochi, H., & Ochiya, T. (2007) · Hepatology · doi:10.1002/hep.21704 · Cited by 555 · see citing works
A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia
S, M. G. B., Rader, D. J., Muller, D. W., Kolansky, D. M., Kozarsky, K., Clark, B. J., Stein, E. A., Lupien, P. J., Brewer, H. B., Raper, S. E., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1148 · Cited by 532 · see citing works
Kuo, T. K., Hung, S., Chuang, C., Chen, C., Shih, Y. V., Fang, S. Y., Yang, V. W., & Lee, O. K. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.015 · Cited by 466 · see citing works
Human Hepatocyte Transplantation: Worldwide Results
Fisher, R. A., & Strom, S. C. (2006) · Transplantation · doi:10.1097/01.tp.0000231689.44266.ac · Cited by 444 · see citing works
The origin and liver repopulating capacity of murine oval cells
Wang, X., Foster, M., Al-Dhalimy, M., Lagasse, E., Finegold, M., & Grompe, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1734199100 · Cited by 410 · see citing works
Hepatocyte transplantation as a treatment for glycogen storage disease type 1a
Muraca, M., Gerunda, G. E., Neri, D., Vilei, M. T., Granato, A., Feltracco, P., Meroni, M., Giron, G., & Burlina, A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07529-3 · Cited by 382 · see citing works
Laconi, E., Oren, R., Mukhopadhyay, D. K., Hurston, E., Laconi, S., Pani, P., Dabeva, M. D., & Shafritz, D. A. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65574-5 · Cited by 381 · see citing works
Höppe, B., Beck, B. B., & Milliner, D. S. (2009) · Kidney International · doi:10.1038/ki.2009.32 · Cited by 376 · see citing works
Hepatocyte Transplantation for the Treatment of Human Disease
Strom, S. C., Chowdhury, J., & Fox, I. J. (1999) · Seminars in Liver Disease · doi:10.1055/s-2007-1007096 · Cited by 375 · see citing works
Ponder, K. P., Gupta, S. K., Leland, F. E., Darlington, G., Finegold, M. J., DeMayo, J. L., Ledley, F. D., Chowdhury, J. R., & Woo, S. L. C. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.4.1217 · Cited by 369 · see citing works
Hepatocyte transplantation in acute liver failure
Bilir, B. M., GUINETTE, D., Karrer, F. M., Kumpe, D. A., Krysl, J., Stephens, J. K., McGavran, L., Ostrowska, A., & Durham, J. D. (2000) · Liver Transplantation · doi:10.1002/lt.500060113 · Cited by 358 · see citing works
Chen, G., Qian, H., Starzl, T. E., Sun, H., Garcia, B. M., Wang, X., Wise, Y., Liu, Y., Xiang, Y., Copeman, L. S., et al. (2005) · Nature Medicine · doi:10.1038/nm1330 · Cited by 357 · see citing works
Isolation of hepatoblasts based on the expression of Dlk/Pref-1
Tanimizu, N., Nishikawa, M., Saito, H., Tsujimura, T., & Miyajima, A. (2003) · Journal of Cell Science · doi:10.1242/jcs.00388 · Cited by 335 · see citing works
The Phenotypes of Pluripotent Human Hepatic Progenitors
Schmelzer, E., Wauthier, E., & Reid, L. M. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0036 · Cited by 333 · see citing works
Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers
Aurich, I., Mueller, L. P., Aurich, H., Luetzkendorf, J., Tisljar, K., Dollinger, M. M., Schormann, W., Walldorf, J., Hengstler, J. G., Fleig, W. E., et al. (2007) · Gut · doi:10.1136/gut.2005.090050 · Cited by 314 · see citing works
Byrne, G. W., McCurry, K. R., Martin, M. J., McClellan, S. M., Platt, J. L., & Logan, J. S. (1997) · Transplantation · doi:10.1097/00007890-199701150-00027 · Cited by 311 · see citing works
HUMAN FETAL HEPATOCYTE TRANSPLANTATION IN PATIENTS WITH FULMINANT HEPATIC FAILURE
Habibullah, C. M., Syed, I. H., Qamar, A., & Taher-Uz, Z. (1994) · Transplantation · doi:10.1097/00007890-199410270-00016 · Cited by 301 · see citing works
Dan, Y. Y., Riehle, K. J., Lázaro, C. A., Teoh, N., Haque, J. A., Campbell, J. S., & Fausto, N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603824103 · Cited by 300 · see citing works
Hepatocellular Transplantation for Metabolic Deficiencies: Decrease of Plasma Bilirubin in Gunn Rats
Matas, A. J., Sutherland, D. E. R., Steffes, M. W., Mauer, S. M., Sowe, A., Simmons, R. L., & Najarian, J. S. (1976) · Science · doi:10.1126/science.818706 · Cited by 295 · see citing works
Isolated Hepatocyte Transplantation in an Infant With a Severe Urea Cycle Disorder
Horslen, S. P., McCowan, T. C., Goertzen, T. C., Warkentin, P. I., Cai, H. B., Strom, S. C., & Fox, I. J. (2003) · Pediatrics · doi:10.1542/peds.111.6.1262 · Cited by 295 · see citing works
Campard, D., Lysy, P. A., Najimi, M., & Sokal, E. M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.12.024 · Cited by 287 · see citing works
Gupta, S. K., Rajvanshi, P., Sokhi, R. P., Slehria, S., Yam, A., Kerr, A. S., & Novikoff, P. M. (1999) · Hepatology · doi:10.1002/hep.510290213 · Cited by 283 · see citing works
Characterization of human embryonic stem cells with features of neoplastic progression
Werbowetski‐Ogilvie, T. E., Bosse, M. M., Stewart, M. H., Schnerch, A., Ramos–Mejía, V., Rouleau, A., Wynder, T., Smith, M.-J., Dingwall, S., Carter, T., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1516 · Cited by 278 · see citing works
Sokal, E. M., Smets, F. N., Bourgois, A., Maldergem, L. V., Buts, J., Reding, R., Otte, J. B., Evrard, V., Latinne, D., Vincent, M. F., et al. (2003) · Transplantation · doi:10.1097/01.tp.0000077420.81365.53 · Cited by 267 · see citing works
Hepatocyte Transplantation for Inherited Factor VII Deficiency
Dhawan, A. K., Mitry, R. R., Hughes, R. D., Lehec, S. C., Terry, C., Bansal, S., Arya, R., Wade, J. J., Verma, A., Heaton, N. D., et al. (2004) · Transplantation · doi:10.1097/01.tp.0000146386.77076.47 · Cited by 261 · see citing works
Self-citationThe stem cell niche of human livers: Symmetry between development and regeneration
Zhang, L., Theise, N. D., Chua, M., & Reid, L. M. (2008) · Hepatology · doi:10.1002/hep.22516 · Cited by 259 · see citing works
Stéphenne, X., Najimi, M., Sibille, C., Nassogne, M., Smets, F. N., & Sokal, E. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.01.008 · Cited by 212 · see citing works
Yamamoto, H., Quinn, G., Asari, A., Yamanokuchi, H., Teratani, T., Terada, M., & Ochiya, T. (2003) · Hepatology · doi:10.1053/jhep.2003.50202 · Cited by 211 · see citing works
Tsai, P.-C., Fu, T.-W., Chen, Y. A., Ko, T.-L., Chen, T.-H., Shih, Y., Hung, S., & Fu, Y.-S. (2009) · Liver Transplantation · doi:10.1002/lt.21715 · Cited by 206 · see citing works
Adult-Derived Human Liver Mesenchymal-Like Cells as a Potential Progenitor Reservoir of Hepatocytes?
Najimi, M., Khuu, D. N., Lysy, P. A., Jazouli, N., Abarca, J., Sempoux, C. L., & Sokal, E. M. (2007) · Cell Transplantation · doi:10.3727/000000007783465154 · Cited by 202 · see citing works
Hepatocyte transplantation for liver‐based metabolic disorders
Dhawan, A. K., Mitry, R. R., & Hughes, R. D. (2006) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-006-0245-8 · Cited by 195 · see citing works
Self-citationHepatocellular transplantation in acute liver failure.
Sutherland, D. E. R., Numata, M., Matas, A. J., Simmons, R. L., & Najarian, J. S. (1977) · PubMed · Cited by 190 · see citing works
Critical Review of Clinical Trials of Bone Marrow Stem Cells in Liver Disease
Houlihan, D. D., & Newsome, P. N. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.05.040 · Cited by 189 · see citing works
Guha, C., Sharma, A., Gupta, S. K., Alfieri, A. A., Gorla, G. R., Gagandeep, S., Sokhi, R. P., Roy-Chowdhury, N., Tanaka, K. E., Vikram, B., et al. (1999) · PubMed · Cited by 189 · see citing works
Isolated Hepatocyte Transplantation for Crigler-Najjar Syndrome Type 1
Ambrosino, G., Varotto, S., Strom, S. C., Guariso, G., Franchin, E., D, D. M. M., Caenazzo, L., Basso, S. M. M., Carraro, P., Valente, M., et al. (2005) · Cell Transplantation · doi:10.3727/000000005783983250 · Cited by 186 · see citing works
De Vree, J. M. L., Ottenhoff, R., Bosma, P. J., Smith, A. J., Aten, J., & Oude Elferink, R. P. J. (2000) · Gastroenterology · doi:10.1053/gast.2000.20222 · Cited by 186 · see citing works
Transplantation of human hepatocytes
Strom, S. C., Fisher, R. A., Rubinstein, W. S., Barranger, J. A., Towbin, R. B., Charron, M., Mieles, L., Pisarov, L. A., Dorko, K., Thompson, M. T., et al. (1997) · Transplantation Proceedings · doi:10.1016/s0041-1345(97)00252-2 · Cited by 171 · see citing works
Selective repopulation of normal mouse liver by Fas/CD95-resistant hepatocytes
Mignon, A., Guidotti, J., Mitchell, C., Fabrè, M., Wernet, A., Coste, A. D. L., Soubrane, O., Gilgenkrantz, H., & Kahn, A. (1998) · Nature Medicine · doi:10.1038/2681 · Cited by 166 · see citing works
Meyburg, J., Das, A. M., Hoerster, F., Lindner, M. S., Kriegbaum, H., Engelmann, G., Schmidt, J., Ott, M., Pettenazzo, A., Luecke, T., et al. (2009) · Transplantation · doi:10.1097/tp.0b013e318199936a · Cited by 162 · see citing works
Outcome and survival of 88 patients with urea cycle disorders: a retrospective evaluation
Bachmann, C. (2003) · European Journal of Pediatrics · doi:10.1007/s00431-003-1188-9 · Cited by 159 · see citing works
Correction of the genetic defect in hepatocytes from the Watanabe heritable hyperlipidemic rabbit.
Wilson, J. M., Johnston, D. E., Jefferson, D. M., & Mulligan, R. C. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.12.4421 · Cited by 153 · see citing works
Rajvanshi, P., Kerr, A. S., Bhargava, K. K., Burk, R. D., & Gupta, S. K. (1996) · Hepatology · doi:10.1002/hep.510230313 · Cited by 152 · see citing works
Heo, J., Factor, V. M., Uren, T., Takahama, Y., Lee, J., Major, M. E., Feinstone, S. M., & Thorgeirsson, S. S. (2006) · Hepatology · doi:10.1002/hep.21441 · Cited by 146 · see citing works
Stéphenne, X., Najimi, M., Smets, F. N., Reding, R., de Goyet, J. D. V., & Sokal, E. M. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2005.00935.x · Cited by 144 · see citing works
Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver
Joseph, B., Malhi, H., Bhargava, K. K., Palestro, C. J., McCuskey, R. S., & Gupta, S. K. (2002) · Gastroenterology · doi:10.1053/gast.2002.36592 · Cited by 140 · see citing works
Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation†
Yamanouchi, K., Zhou, H., Roy‐Chowdhury, N., Macaluso, F., Liu, L., Yamamoto, T., Yannam, G. R., Enke, C. A., Solberg, T. D., Adelson, A. B., et al. (2008) · Hepatology · doi:10.1002/hep.22573 · Cited by 139 · see citing works
Yasui, O., Miura, N., Terada, K., Kawarada, Y., Koyama, K., & Sugiyama, T. (1997) · Hepatology · doi:10.1002/hep.510250213 · Cited by 133 · see citing works
Long-term outcome of patients with urea cycle disorders and the question of neonatal screening
Bachmann, C. (2003) · European Journal of Pediatrics · doi:10.1007/s00431-003-1347-z · Cited by 129 · see citing works
Oertel, M., Menthena, A., Chen, Y., Teisner, B., Jensen, C. H., & Shafritz, D. A. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.007 · Cited by 125 · see citing works
Yoshida, Y., Tokusashi, Y., Lee, G., & Ogawa, K. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70029-x · Cited by 122 · see citing works
Horslen, S. P., & Fox, I. J. (2004) · Transplantation · doi:10.1097/01.tp.0000113809.53415.c2 · Cited by 119 · see citing works
Puppi, J., Tan, N., Mitry, R. R., Hughes, R. D., Lehec, S., Mieli‐Vergani, G., Karani, J. B., Champion, M. P., Heaton, N. D., Mohamed, R., et al. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.02058.x · Cited by 116 · see citing works
Self-citationRajvanshi, P., Kerr, A. S., Bhargava, K. K., Burk, R. D., & Gupta, S. K. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70078-1 · Cited by 116 · see citing works
Terry, C., Dhawan, A. K., Mitry, R. R., Lehec, S. C., & Hughes, R. D. (2010) · Liver Transplantation · doi:10.1002/lt.21983 · Cited by 114 · see citing works
Self-citationHuman Hepatocyte Isolation and Relationship of Cell Viability to Early Graft Function
Mitry, R. R., Hughes, R. D., Aw, M., Terry, C., Mieli‐Vergani, G., Girlanda, R., Muiesan, P., Rela, M., Heaton, N. D., & Dhawan, A. K. (2003) · Cell Transplantation · doi:10.3727/000000003783985197 · Cited by 113 · see citing works
Self-citationLiver cell transplantation for Crigler-Najjar syndrome type I: Update and perspectives
Lysy, P. A., Najimi, M., Stéphenne, X., Bourgois, A., Smets, F. N., & Sokal, E. M. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.3464 · Cited by 107 · see citing works
Malhi, H., Gorla, G. R., Irani, A. N., Annamaneni, P., & Gupta, S. K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192365499 · Cited by 105 · see citing works
DEFINING HEPATOCELLULAR CHIMERISM IN A LIVER FAILURE PATIENT BRIDGED WITH HEPATOCYTE INFUSION 1
Fisher, R. A., Bu, D., Thompson, M. T., Tisnado, J., Prasad, U. N., Sterling, R. K., Posner, M. P., & Strom, S. C. (2000) · Transplantation · doi:10.1097/00007890-200001270-00018 · Cited by 100 · see citing works
Slehria, S., Rajvanshi, P., Ito, Y., Sokhi, R. P., Bhargava, K. K., Palestro, C. J., McCuskey, R. S., & Gupta, S. K. (2002) · Hepatology · doi:10.1053/jhep.2002.33201 · Cited by 100 · see citing works
Cryopreservation of isolated human hepatocytes for transplantation: State of the art
Terry, C., Dhawan, A. K., Mitry, R. R., & Hughes, R. D. (2006) · Cryobiology · doi:10.1016/j.cryobiol.2006.05.004 · Cited by 97 · see citing works
Self-citationHepatocyte Transplantation for Glycogen Storage Disease Type Ib
Lee, K.-W., Lee, J., Shin, S. W., Kim, S. J., Joh, J., Lee, D., Kim, J., Park, H.-Y., Lee, S., Lee, H. H., et al. (2007) · Cell Transplantation · doi:10.3727/000000007783465019 · Cited by 94 · see citing works
Krohn, N., Kapoor, S., Enami, Y., Follenzi, A., Bandi, S., Joseph, B., & Gupta, S. K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.063 · Cited by 93 · see citing works
Isolation of hepatocytes from livers from non-heart-beating donors for cell transplantation
Hughes, R. D., Mitry, R. R., Dhawan, A. K., Lehec, S. C., Girlanda, R., Rela, M., Heaton, N. D., & Muiesan, P. (2006) · Liver Transplantation · doi:10.1002/lt.20732 · Cited by 93 · see citing works
Self-citationWang, L., Chen, Y. M., George, D., Smets, F., Sokal, E. M., Bremer, E. G., & Soriano, H. E. (2002) · Liver Transplantation · doi:10.1053/jlts.2002.34891 · Cited by 92 · see citing works
Cell-mediated rejection results in allograft loss after liver cell transplantation
Allen, K. J., Mifsud, N. A., Williamson, R., Bertolino, P., & Hardikar, W. (2008) · Liver Transplantation · doi:10.1002/lt.21443 · Cited by 89 · see citing works
Hepatocyte Transplantation in an Acute Liver Failure Due to Mushroom Poisoning
Schneider, A. L. C., Attaran-Bandarabadi, M., Meier, P. N., Strassburg, C. P., Manns, M. P., Ott, M., Barthold, M., Arseniev, L., Becker, T., & Panning, B. (2006) · Transplantation · doi:10.1097/01.tp.0000232451.93703.ab · Cited by 89 · see citing works
Prolonged Survival of Porcine Hepatocytes in Cynomolgus Monkeys
Nagata, H., Nishitai, R., Shirota, C., Zhang, J.-L., Koch, C. A., Cai, J., Awwad, M., Schuurman, H., Christians, U., Abe, M., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.10.013 · Cited by 89 · see citing works
Malhi, H., Annamaneni, P., Slehria, S., Joseph, B., Bhargava, K. K., Palestro, C. J., Novikoff, P. M., & Gupta, S. K. (2002) · Hepatology · doi:10.1053/jhep.2002.33896 · Cited by 88 · see citing works
AFP + , ESC‐Derived Cells Engraft and Differentiate into Hepatocytes in Vivo
Yin, Y., Lim, Y. K., Salto‐Tellez, M., Ng, S. C., Lin, C., & Lim, S. K. (2002) · Stem Cells · doi:10.1634/stemcells.20-4-338 · Cited by 80 · see citing works
Permanent access to the portal system for cellular transplantation using an implantable port device
Darwish, A. A., Sokal, E. M., Stéphenne, X., Najimi, M., de Goyet, J. D. V., & Reding, R. (2004) · Liver Transplantation · doi:10.1002/lt.20228 · Cited by 79 · see citing works
Liver cell transplantation: The road to clinical application
Allen, K. J., & Soriano, H. E. (2001) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2001.119148 · Cited by 76 · see citing works
Stephenne, X., Vosters, O., Najimi, M., Beuneu, C., Ngoc, D. K., Wijns, W., Goldman, M., & Sokal, E. (2007) · Liver transplantation · doi:10.1002/lt.21128 · Cited by 73 · see citing works
Liver regeneration and recanalization time course following reversible portal vein embolization
Laïnas, P., Boudechiche, L., Osorio, A., L’Herminé, A. C., Weber, A., Pariente, D., Franco, D., & Dagher, I. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.01.034 · Cited by 73 · see citing works
Mai, G., Huy, N. T., Morel, P., Mei, J., Andrès, A., Bosco, D., Baertschiger, R. M., Toso, C., Berney, T., Majno, P. E., et al. (2005) · Xenotransplantation · doi:10.1111/j.1399-3089.2005.00248.x · Cited by 69 · see citing works
Neurological findings in early treated phenylketonuria
Weglage, J., Pietsch, M., Fünders, B., Koch, H., & Ullrich, K. (1995) · Acta Paediatrica · doi:10.1111/j.1651-2227.1995.tb13661.x · Cited by 69 · see citing works
Bohnen, N. I., Charron, M., Reyes, J. D., Rubinstein, W. S., Strom, S. C., Swanson, D. P., & Towbin, R. B. (2000) · Clinical Nuclear Medicine · doi:10.1097/00003072-200006000-00012 · Cited by 69 · see citing works
Joseph, B., Kumaran, V., Berishvili, E., Bhargava, K. K., Palestro, C. J., & Gupta, S. K. (2006) · Hepatology · doi:10.1002/hep.21416 · Cited by 64 · see citing works
Dagher, I., Nguyen, T. H., Picard‐Groyer, M., Laïnas, P., Goulinet, S., Guettier, C., Pariente, D., Franco, D., & Weber, A. (2008) · Hepatology · doi:10.1002/hep.22739 · Cited by 63 · see citing works
Efficient Hepatocyte Engraftment in a Nonhuman Primate Model After Partial Portal Vein Embolization
Dagher, I., Boudechiche, L., Branger, J., L’Herminé, A. C., Parouchev, A., Sentilhes, L., Lin, T., Picard‐Groyer, M., Vons, C., Hadchouel, M., et al. (2006) · Transplantation · doi:10.1097/01.tp.0000236103.99456.8f · Cited by 62 · see citing works
Khan, A. A., Habeeb, A., Parveen, N., Naseem, B., Babu, R. P., Capoor, A. K., & Habibullah, C. M. (2004) · PubMed · Cited by 62 · see citing works
Gupta, S. K., Chowdhury, N. R., Jagtiani, R. K., Gustin, K. E., Aragona, E., Shafritz, D. A., Chowdhury, J. R., & Burk, R. D. (1990) · Transplantation · doi:10.1097/00007890-199009000-00022 · Cited by 62 · see citing works
The Effects of Cryopreservation on Human Hepatocytes Obtained from Different Sources of Liver Tissue
Terry, C., Mitry, R. R., Lehec, S. C., Muiesan, P., Rela, M., Heaton, N. D., Hughes, R. D., & Dhawan, A. K. (2005) · Cell Transplantation · doi:10.3727/000000005783982765 · Cited by 61 · see citing works
Self-citationPrinciples of therapeutic liver repopulation
Grompe, M. (2006) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-006-0311-2 · Cited by 59 · see citing works
Liver after Hepatocyte Transplantation for Liver-Based Metabolic Disorders in Children
Quaglia, A., Lehec, S. C., Hughes, R. D., Mitry, R. R., Knisely, A. S., Devereaux, S., Richards, J., Rela, M., Heaton, N. D., Portmann, B. C., et al. (2008) · Cell Transplantation · doi:10.3727/096368908787648083 · Cited by 53 · see citing works
Self-citationMalhi, H., Joseph, B., Schilsky, M. L., & Gupta, S. K. (2008) · Regenerative Medicine · doi:10.2217/17460751.3.2.165 · Cited by 52 · see citing works
Feasibility of Hepatocyte Transplantation-Based Therapies for Primary Hyperoxalurias
Guha, C., Yamanouchi, K., Jiang, J., Wang, X., Chowdhury, N. R., Santana, A., Shapiro, L. J., SALIDO, E. C., & Roy‐Chowdhury, J. (2005) · American Journal of Nephrology · doi:10.1159/000085408 · Cited by 48 · see citing works
Progenitor Cell Characterization and Location in the Developing Human Liver
Terrace, J. D., Currie, I. S., Hay, D. C., Masson, N. M., Anderson, R. A., Forbes, S. J., Parks, R. W., & Ross, J. A. (2007) · Stem Cells and Development · doi:10.1089/scd.2007.0016 · Cited by 46 · see citing works
Transplantation of Hepatocytes for Treatment of Surgically Induced Acute Hepatic Failure in the Rat
Minato, M., Houssin, D. P., Demma, I., Morin, J., Gigou, M., Szekely, A. M., & Bismuth, H. (2008) · European Surgical Research · doi:10.1159/000128404 · Cited by 45 · see citing works
Application of liver stem cells for cell therapy
Alison, M. R., Choong, C. S. N., & Lim, S. M. L. (2007) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2007.09.016 · Cited by 42 · see citing works
Cheng, K., Benten, D., Bhargava, K. K., Inada, M., Joseph, B., Palestro, C. J., & Gupta, S. K. (2009) · Hepatology · doi:10.1002/hep.23120 · Cited by 39 · see citing works
Optimization of Conditions for Clinical Human Hepatocyte Infusion
Fisher, R. A., Bu, D., Thompson, M. T., Wolfe, L. G., & Ritter, J. K. (2004) · Cell Transplantation · doi:10.3727/000000004783983576 · Cited by 38 · see citing works
Mas, V. R., Maluf, D. G., Thompson, M. T., Ferreira‐Gonzalez, A., & Fisher, R. A. (2004) · Cell Transplantation · doi:10.3727/000000004783983945 · Cited by 35 · see citing works
David, P., Alexandre, E., Audet, M., Chenard, M., Wolf, P., Jaeck, D., Azimzadeh, A. M., & Richert, L. (2001) · Cell Transplantation · doi:10.3727/000000001783987034 · Cited by 34 · see citing works
Kim, K. S., Joseph, B., Inada, M., & Gupta, S. K. (2005) · Transplantation · doi:10.1097/01.tp.0000173382.11916.bf · Cited by 33 · see citing works
Ex vivo hepatic gene transfer in mouse using a defective herpes simplex virus-1 vector
Lu, B., Gupta, S. K., & Federoff, H. J. (1995) · Hepatology · doi:10.1002/hep.1840210324 · Cited by 32 · see citing works
Irradiation as preparative regimen for hepatocyte transplantation causes prolonged cell cycle block
Koenig, S., Krause, P., Schmidt, T.-K., Rave‐Fränk, M., Rothe, H., Hermann, R. M., Heinz Becker, A., Hess, C. F., & Christiansen, H. (2008) · International Journal of Radiation Biology · doi:10.1080/09553000801953359 · Cited by 29 · see citing works
Poncelet, A. J., Dufrane, D., & Gianello, P. (2009) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e3283292522 · Cited by 28 · see citing works
UW solution: a promising tool for cryopreservation of primarily isolated rat hepatocytes
Arikura, J., Kobayashi, N., Okitsu, T., Noguchi, H., Totsugawa, T., Watanabe, T., Matsumura, T., Maruyama, M., Kosaka, Y., Tanaka, N., et al. (2002) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s005340200103 · Cited by 28 · see citing works
Noninvasive imaging of transplanted cells
Modo, M. (2008) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e328317a43c · Cited by 25 · see citing works
Pera, M. F. (2001) · Reproduction Fertility and Development · doi:10.1071/rd00077 · Cited by 22 · see citing works
Land, V. J., Zarkowsky, H. S., & Vietti, T. J. (1970) · New England Journal of Medicine · doi:10.1056/nejm197002122820720 · Cited by 20 · see citing works
Sodium benzoate and arginine: alternative pathway therapy in inborn errors of urea synthesis.
Ml, B. (1983) · PubMed · Cited by 19 · see citing works
Early primary biliary cirrhosis: Just delayed or different?
Lindor, K. D. (1997) · Hepatology · doi:10.1002/hep.510260135 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Zhang, W., Wang, R., Sun, Z., Zhu, X., Zhao, Q., Zhang, T., Cholewinski, A., Yang, F. K., Zhao, B., Pinnaratip, R., et al. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00285e · Cited by 988 · see citing works
Supramolecular Adhesive Hydrogels for Tissue Engineering Applications
Zhao, Y., Song, S., Ren, X., Zhang, J., Lin, Q., & Zhao, Y. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00815 · Cited by 714 · see citing works
Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes
Huang, P., Zhang, L., Gao, Y., He, Z., Yao, D., Wu, Z., Cen, J., Chen, X., Liu, C., Hu, Y., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.01.003 · Cited by 560 · see citing works
Acetaminophen hepatotoxicity: an updated review
Lancaster, E. M., Hiatt, J. R., & Zarrinpar, A. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1432-2 · Cited by 337 · see citing works
Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming
Du, Y., Wang, J., Jia, J., Song, N., Xiang, C., Xu, J., Hou, Z., Su, X., Liu, B., Jiang, T., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.01.008 · Cited by 320 · see citing works
Cell and tissue engineering for liver disease
Bhatia, S. N., Underhill, G. H., Zaret, K. S., & Fox, I. J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3005975 · Cited by 309 · see citing works
Liver regeneration and inflammation: from fundamental science to clinical applications
Campana, L., Esser, H., Huch, M., & Forbes, S. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00373-7 · Cited by 307 · see citing works
Use of differentiated pluripotent stem cells in replacement therapy for treating disease
Fox, I. J., Daley, G. Q., Goldman, S. A., Huard, J., Kamp, T. J., & Trucco, M. (2014) · Science · doi:10.1126/science.1247391 · Cited by 291 · see citing works
In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity
Zhang, K., Zhang, L., Liu, W., Ma, X., Cen, J., Sun, Z., Wang, C., Feng, S., Zhang, Z., Yue, L., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.10.018 · Cited by 252 · see citing works
Human hepatocyte transplantation for liver disease: current status and future perspectives
Iansante, V, Mitry, R. R., Filippi, C., Fitzpatrick, E., & Dhawan, A. (2018) · Pediatric Research · doi:10.1038/pr.2017.284 · Cited by 225 · see citing works
Self-citationCell sheet approach for tissue engineering and regenerative medicine.
Matsuura, K., Utoh, R., Nagase, K., & Okano, T. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.024 · Cited by 225 · see citing works
Current Status of Hepatocyte Transplantation
Hughes, R. D., Mitry, R. R., & Dhawan, A. K. (2011) · Transplantation · doi:10.1097/tp.0b013e31823b72d6 · Cited by 186 · see citing works
Self-citationWu, X., Robotham, J. M., Lee, E., Dalton, S., Kneteman, N. M., Gilbert, D. M., & Tang, H. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002617 · Cited by 166 · see citing works
Liver support strategies: cutting-edge technologies
Struecker, B., Raschzok, N., & Sauer, I. M. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.204 · Cited by 165 · see citing works
Large‐Scale Production of LGR5‐Positive Bipotential Human Liver Stem Cells
Schneeberger, K., Sánchez‐Romero, N., Ye, S., van Steenbeek, F. G., Oosterhoff, L. A., Pla Palacin, I., Chen, C., van Wolferen, M. E., van Tienderen, G., Lieshout, R., et al. (2020) · Hepatology · doi:10.1002/hep.31037 · Cited by 141 · see citing works
The multiple functional roles of mesenchymal stem cells in participating in treating liver diseases
Liu, W., Song, F., Ren, L., Guo, W., Wang, T., Feng, Y., Tang, L., & Li, K. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12482 · Cited by 139 · see citing works
Vosough, M., Omidinia, E., Kadivar, M., Shokrgozar, M. A., Pournasr, B., Aghdami, N., & Baharvand, H. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0088 · Cited by 132 · see citing works
Liver tissue engineering: From implantable tissue to whole organ engineering
Mazza, G., Al‐Akkad, W., Rombouts, K., & Pinzani, M. (2017) · Hepatology Communications · doi:10.1002/hep4.1136 · Cited by 127 · see citing works
Nicolas, C. T., Hickey, R., Chen, H. S., Mao, S. A., Higuita, M. L., Wang, Y., & Nyberg, S. L. (2016) · Stem Cells · doi:10.1002/stem.2500 · Cited by 127 · see citing works
Host conditioning and rejection monitoring in hepatocyte transplantation in humans
Soltys, K. A., Setoyama, K., Tafaleng, E. N., Soto–Gutiérrez, A., Fong, J. V., Fukumitsu, K., Nishikawa, T., Nagaya, M., Sada, R., Haberman, K., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.12.017 · Cited by 124 · see citing works
Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids
Assawarachan, S. N., Spee, B., Kruitwagen, H. S., Chen, C., Geijsen, N., Oosterhoff, L. A., van Wolferen, M. E., Pelaez-Llaneza, N., Fieten, H., Wubbolts, R., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.09.002 · Cited by 117 · see citing works
Hepatocyte transplantation for inherited metabolic diseases of the liver
Jorns, C., Ellis, E. C. S., Nowak, G., Fischler, B., Németh, A., Strom, S. C., & Ericzon, B. (2012) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02574.x · Cited by 116 · see citing works
Cellular Mechanisms of Liver Regeneration and Cell-Based Therapies of Liver Diseases
Kholodenko, I. V., & Yarygin, K. N. (2017) · BioMed Research International · doi:10.1155/2017/8910821 · Cited by 113 · see citing works
Hepatocellular carcinoma treatment: hurdles, advances and prospects
Kumari, R., V, Sahu, M. K., Tripathy, A., Uthansingh, K., & Behera, M. K. (2018) · Hepatic Oncology · doi:10.2217/hep-2018-0002 · Cited by 112 · see citing works
Alginate microencapsulated human hepatocytes for the treatment of acute liver failure in children
Dhawan, A. K., Chaijitraruch, N., Fitzpatrick, E., Bansal, S., Filippi, C., Lehec, S. C., Heaton, N. D., Kane, P., Verma, A., Hughes, R. D., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.12.002 · Cited by 111 · see citing works
Self-citationThe mouse lymph node as an ectopic transplantation site for multiple tissues
Komori, J., Boone, L., DeWard, A. D., Hoppo, T., & Lagasse, E. (2012) · Nature Biotechnology · doi:10.1038/nbt.2379 · Cited by 109 · see citing works
Clinical Hepatocyte Transplantation: Practical Limits and Possible Solutions
Gramignoli, R., Vosough, M., Kannisto, K., Srinivasan, R. C., & Strom, S. C. (2015) · European Surgical Research · doi:10.1159/000369552 · Cited by 108 · see citing works
Du, C., Feng, Y., Qiu, D., Xu, Y., Pang, M., Cai, N., Xiang, A. P., & Zhang, Q. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0794-4 · Cited by 106 · see citing works
The History and Use of Human Hepatocytes for the Treatment of Liver Diseases: The First 100 Patients
Hansel, M. C., Gramignoli, R., Skvorak, K. J., Dorko, K., Marongiu, F., Blake, W. L., Davila, J., & Strom, S. C. (2014) · Current Protocols in Toxicology · doi:10.1002/0471140856.tx1412s62 · Cited by 100 · see citing works
Cell Therapies for Liver Diseases
Yu, Y., Fisher, J. E., Lillegard, J. B., Rodysill, B. R., Amiot, B. P., & Nyberg, S. L. (2011) · Liver Transplantation · doi:10.1002/lt.22467 · Cited by 100 · see citing works
Organ transplantation in the modern era
Bezinover, D. S., & Saner, F. H. (2019) · BMC Anesthesiology · doi:10.1186/s12871-019-0704-z · Cited by 98 · see citing works
Transplantation of hESC-derived hepatocytes protects mice from liver injury
Tolosa, L., Caron, J., Hannoun, Z., Antoni, M., López, S. A., Burks, D. J., Castell, J. V., Weber, A., Gómez‐Lechón, M. J., & Dubart‐Kupperschmitt, A. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0227-6 · Cited by 95 · see citing works
Pre‐treatments enhance the therapeutic effects of mesenchymal stem cells in liver diseases
Hu, C., Wu, Z., & Li, L. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14788 · Cited by 93 · see citing works
Human liver stem cells improve liver injury in a model of fulminant liver failure
Sanchez, M. B. H., Fonsato, V., Bruno, S., Grange, C., Gilbo, N., Romagnoli, R., Tetta, C., & Camussi, G. (2012) · Hepatology · doi:10.1002/hep.25986 · Cited by 92 · see citing works
Direct Reprogramming of Human Fibroblasts to Hepatocyte-Like Cells by Synthetic Modified mRNAs
Simeonov, K. P., & Uppal, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100134 · Cited by 87 · see citing works
Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential
Liu, P., Mao, Y., Xie, Y., Wei, J., & Yao, J. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03041-5 · Cited by 82 · see citing works
Lee, S. Y., Kim, H., & Choi, D. (2015) · International Journal of Stem Cells · doi:10.15283/ijsc.2015.8.1.36 · Cited by 80 · see citing works
Zhang, S.-C., Chen, L., Liu, T., Zhang, B., Xiang, D., Wang, Z., & Wang, Y. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0516 · Cited by 79 · see citing works
Liver transplantation in children: state of the art and future perspectives
Kohli, R., Cerisuelo, M. C., Heaton, N. D., & Dhawan, A. K. (2017) · Archives of Disease in Childhood · doi:10.1136/archdischild-2015-310023 · Cited by 80 · see citing works
Self-citationMesenchymal Stem Cells for the Treatment of Liver Disease: Present and Perspectives
Kang, S. H., Kim, M. Y., Eom, Y. W., & Baik, S. K. (2020) · Gut and Liver · doi:10.5009/gnl18412 · Cited by 78 · see citing works
Shaheen, M. F., Joo, D. J., Ross, J. J., Anderson, B. D., Chen, H. S., Huebert, R. C., Li, Y., Amiot, B., Young, A., Zlochiver, V., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0460-x · Cited by 75 · see citing works
Capone, S. H., Dufresne, M., Rechel, M., Fleury, M., Salsac, A., Paullier, P., Daujat‐Chavanieu, M., & Legallais, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062032 · Cited by 75 · see citing works
Lee, C. A., Sinha, S., Fitzpatrick, E., & Dhawan, A. K. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1638-5 · Cited by 74 · see citing works
Self-citationZhou, P., Huang, Y., Guo, Y., Wang, L., Ling, C., Guo, Q., Wang, Y., Zhu, S., Fan, X., Zhu, M., et al. (2016) · Artificial Organs · doi:10.1111/aor.12645 · Cited by 73 · see citing works
Cellular Therapy for Liver Disease
Huebert, R. C., & Rakela, J. L. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.10.023 · Cited by 71 · see citing works
Yi, F., Liu, G., & Belmonte, J. C. I. (2012) · Protein & Cell · doi:10.1007/s13238-012-2918-4 · Cited by 71 · see citing works
Burgard, P., Kölker, S., Haege, G., Lindner, M. S., & Hoffmann, G. F. (2015) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-015-9901-1 · Cited by 71 · see citing works
Hepatocyte transplantation program: Lessons learned and future strategies
Pareja, E. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i2.874 · Cited by 68 · see citing works
Liver regeneration: Cellular origin and molecular mechanisms
Huang, R. C. C., Zhang, X., Gracia‐Sancho, J., & Xie, W. (2022) · Liver International · doi:10.1111/liv.15174 · Cited by 68 · see citing works
Evidence for multipotent endodermal stem/progenitor cell populations in human gallbladder
Carpino, G., Cardinale, V., Gentile, R., Onori, P., Semeraro, R., Franchitto, A., Wang, Y., Bosco, D., Iossa, A., Napoletano, C., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.01.026 · Cited by 66 · see citing works
Engineering Liver Microtissues for Disease Modeling and Regenerative Medicine
Huang, D. (., Gibeley, S. B., Xu, C., Xiao, Y., Celik, O., Ginsberg, H. N., & Leong, K. W. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909553 · Cited by 65 · see citing works
Fitzpatrick, E., Wu, Y., Dhadda, P. K., Hughes, R. D., Mitry, R. R., Qin, H., Lehec, S. C., Heaton, N. D., & Dhawan, A. K. (2013) · Cell Transplantation · doi:10.3727/096368913x674080 · Cited by 61 · see citing works
Self-citationCardinale, V., Carpino, G., Gentile, R., Napoletano, C., Rahimi, H., Franchitto, A., Semeraro, R., Nuti, M., Onori, P., Berloco, P. B., et al. (2014) · BMC Gastroenterology · doi:10.1186/s12876-014-0204-z · Cited by 61 · see citing works
Yap, K. K., Dingle, A. M., Palmer, J. A., Dhillon, R. S., Lokmic‐Tomkins, Z., Penington, A., Yeoh, G. C., Morrison, W. A., & Mitchell, G. M. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.02.011 · Cited by 61 · see citing works
Kojima, H., Yasuchika, K., Fukumitsu, K., Ishii, T., Ogiso, S., Miyauchi, Y., Yamaoka, R., Kawai, T., Katayama, H., Yoshitoshi-Uebayashi, E. Y., et al. (2018) · American Journal of Transplantation · doi:10.1111/ajt.14666 · Cited by 60 · see citing works
Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine
Giancotti, A., Monti, M., Nevi, L., Safarikia, S., D’Ambrosio, V., Brunelli, R., Pajno, C., Corno, S., Donato, V. D., Musella, A., et al. (2019) · Cells · doi:10.3390/cells8080914 · Cited by 60 · see citing works
Human Pluripotent Stem Cells for Modelling Human Liver Diseases and Cell Therapy
Dianat, N., Steichen, C., Vallier, L., Weber, A., & Dubart‐Kupperschmitt, A. (2013) · Current Gene Therapy · doi:10.2174/1566523211313020006 · Cited by 60 · see citing works
A Hepatic Scaffold from Decellularized Liver Tissue: Food for Thought
Croce, S., Peloso, A., Zoro, T., Avanzini, M. A., & Cobianchi, L. (2019) · Biomolecules · doi:10.3390/biom9120813 · Cited by 58 · see citing works
Clinical human hepatocyte transplantation: Current status and challenges
Dhawan, A. K. (2015) · Liver Transplantation · doi:10.1002/lt.24226 · Cited by 57 · see citing works
Self-citationLee, S. B., Seo, D., Choi, D., Park, K.-Y., Holczbauer, A., Marquardt, J. U., Conner, E., Factor, V., & Thorgeirsson, S. (2012) · Stem Cells · doi:10.1002/stem.1074 · Cited by 57 · see citing works
Cell-based liver therapies: past, present and future
Iansante, V., Chandrashekran, A., & Dhawan, A. K. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0229 · Cited by 52 · see citing works
Self-citationNeonatal Livers: A Source for the Isolation of Good-Performing Hepatocytes for Cell Transplantation
Tolosa, L., Pareja-Ibars, E., Donato, M. T., Cortés, M., López, S. A., Jiménez, N., Mir, J., Castell, J. V., & Gómez-Lechón, M. J. (2013) · Cell Transplantation · doi:10.3727/096368913x669743 · Cited by 52 · see citing works
Lee, C., Dhawan, A., Smith, R., Mitry, R., & Fitzpatrick, E. (2016) · Cell Transplantation · doi:10.3727/096368916x691286 · Cited by 45 · see citing works
Self-citationOrganoids and regenerative hepatology
Jalan‐Sakrikar, N., Brevini, T., Huebert, R. C., & Sampaziotis, F. (2022) · Hepatology · doi:10.1002/hep.32583 · Cited by 50 · see citing works
Lu, W., Qu, J., Yan, L., Tang, X., Wang, X., Ye, A., Zou, Z., Li, L., Ye, J., & Zhou, L. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03518-x · Cited by 49 · see citing works
Yu, Y., Song, Y., Chen, Y., Zhang, F., & Qi, F. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9181 · Cited by 49 · see citing works
Doddapaneni, R., Chawla, Y. K., Das, A., Kalra, J. K., Ghosh, S., & Chakraborti, A. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24499 · Cited by 48 · see citing works
Adipose-derived stem cell-based treatment for acute liver failure
Chen, G., Jin, Y., Shi, X., Qiu, Y., Zhang, Y., Cheng, M., Wang, X., Chen, C., Wu, Y., Jiang, F., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0040-2 · Cited by 48 · see citing works
Skvorak, K. J., Dorko, K., Marongiu, F., Tahan, V., Hansel, M. C., Gramignoli, R., Arning, E., Bottiglieri, T., Gibson, K. M., & Strom, S. C. (2013) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2013.02.011 · Cited by 46 · see citing works
Current status of human hepatocyte transplantation and its potential for Wilson's disease
Filippi, C., & Dhawan, A. K. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12386 · Cited by 45 · see citing works
Self-citationCurrent Status of Human Adipose–Derived Stem Cells: Differentiation into Hepatocyte-Like Cells
Battah, F. A., Kock, J. D., Vanhaecke, T., & Rogiers, V. (2011) · The Scientific World JOURNAL · doi:10.1100/tsw.2011.146 · Cited by 45 · see citing works
Li, Y., Kim, B.-G., Qian, S., Letterio, J. J., Fung, J. J., Lu, L., & Lin, F. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500139 · Cited by 45 · see citing works
Yuan, J., Li, W., Huang, J., Guo, X., Li, X., Lü, X., Huang, X., & Zhang, H. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0208-9 · Cited by 45 · see citing works
Prasajak, P., & Leeanansaksiri, W. (2013) · Stem Cells International · doi:10.1155/2013/762196 · Cited by 44 · see citing works
Qin, H. H., Filippi, C., Sun, S., Lehec, S. C., Dhawan, A. K., & Hughes, R. D. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0218-7 · Cited by 44 · see citing works
Self-citationManagement of acute-on-chronic liver failure: an algorithmic approach
Sarin, S. K., & Choudhury, A. K. (2018) · Hepatology International · doi:10.1007/s12072-018-9887-5 · Cited by 44 · see citing works
Lin, J. S., Zhou, L., Sagayaraj, A., Jumat, N. H. B., Choolani, M. A., Chan, J. K. Y., Biswas, A., Wong, P. C., Lim, S. G., & Dan, Y. Y. (2015) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12991 · Cited by 43 · see citing works
A Rational Strategy for the Use of Amniotic Epithelial Stem Cell Therapy for Liver Diseases
Miki, T. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0304 · Cited by 43 · see citing works
From organoids to organs: Bioengineering liver grafts from hepatic stem cells and matrix
Willemse, J., Lieshout, R., van der Laan, L. J. W., & Verstegen, M. M. A. (2017) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2017.03.003 · Cited by 44 · see citing works
Qin, J., Chang, M., Wang, S., Liu, Z., Zhu, W. Z., Wang, Y., Yan, F., Li, J., Zhang, B., Dou, G., et al. (2016) · Scientific Reports · doi:10.1038/srep37388 · Cited by 43 · see citing works
Nguyen, M. P., Jain, V., Iansante, V., Mitry, R. R., Filippi, C., & Dhawan, A. K. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2020.1733975 · Cited by 42 · see citing works
Self-citationPatch grafting, strategies for transplantation of organoids into solid organs such as liver
Zhang, W., Lanzoni, G., Hani, H., Overi, D., Cardinale, V., Simpson, S. G., Pitman, W. A., Allen, A. J., Yi, X., Wang, X., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121067 · Cited by 41 · see citing works
Cantz, T., Sharma, A. D., & Ott, M. (2014) · Stem Cells · doi:10.1002/stem.1920 · Cited by 39 · see citing works
Riccio, M., Carnevale, G., Cardinale, V., Gibellini, L., Biasi, S. D., Pisciotta, A., Carpino, G., Gentile, R., Berloco, P. B., Brunelli, R., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.06.016 · Cited by 40 · see citing works
Clinical Application of Pluripotent Stem Cells
Tolosa, L., Pareja, E., & Gómez-Lechón, M. J. (2016) · Transplantation · doi:10.1097/tp.0000000000001426 · Cited by 39 · see citing works
Liver regeneration--the best kept secret. A model of tissue injury response.
Cienfuegos, J. A., Rotellar, F., Baixauli, J., Martínez-Regueira, F., Pardo, F., & Hernández-Lizoáin, J. L. (2014) · PubMed · Cited by 40 · see citing works
Acute-on-chronic Liver Failure
Sarin, S. K., & Choudhury, A. K. (2016) · Current Gastroenterology Reports · doi:10.1007/s11894-016-0535-8 · Cited by 38 · see citing works
Curative Ex Vivo Hepatocyte-Directed Gene Editing in a Mouse Model of Hereditary Tyrosinemia Type 1
VanLith, C. J., Guthman, R. M., Nicolas, C. T., Allen, K. L., Du, Z., Joo, D. J., Nyberg, S. L., Lillegard, J. B., & Hickey, R. (2018) · Human Gene Therapy · doi:10.1089/hum.2017.252 · Cited by 39 · see citing works
Cell-based therapy for acute and chronic liver failures: Distinct diseases, different choices
Sun, K., Xie, X., Xie, J., Jiao, S., Chen, X., Zhao, X., Wang, X., & Wei, L. (2014) · Scientific Reports · doi:10.1038/srep06494 · Cited by 37 · see citing works
Hepatic encephalopathy: An updated approach from pathogenesis to treatment
Toris, G. T., Bikis, C., Tsourouflis, G. S., & Theocharis, S. E. (2011) · Medical Science Monitor · doi:10.12659/msm.881387 · Cited by 38 · see citing works
Liver cell therapy and tissue engineering for transplantation
Vacanti, J. P., & Kulig, K. M. (2014) · Seminars in Pediatric Surgery · doi:10.1053/j.sempedsurg.2014.05.001 · Cited by 36 · see citing works
Iwanaka, T., Yamaza, T., Sonoda, S., Yoshimaru, K., Matsuura, T., Yamaza, H., Ohga, S., Oda, Y., & Taguchi, T. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01630-w · Cited by 37 · see citing works
Sharma, A., Rawal, P., Tripathi, D. M., Alodiya, D., Sarin, S. K., Kaur, S., & Ghosh, S. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00671 · Cited by 37 · see citing works
Pahk, K. J., Mohammad, G. H., Malagó, M., Saffari, N., & Dhar, D. K. (2016) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2016.03.020 · Cited by 35 · see citing works
Chen, L., Zhang, J., Yang, L., Zhang, G., Wang, Y., & Zhang, S.-C. (2018) · Stem Cells International · doi:10.1155/2018/9156560 · Cited by 35 · see citing works
Liao, Q.-Q., Zhao, S., Cai, B., He, R., Rao, L., Wu, Y., Guo, S., Liu, Q., Liu, W., & Zhao, X. (2018) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2018.06.006 · Cited by 34 · see citing works
Generation of functional human hepatocytes in vitro: current status and future prospects
Yamaguchi, T., Matsuzaki, J., Katsuda, T., Saito, Y., Saito, H., & Ochiya, T. (2019) · Inflammation and Regeneration · doi:10.1186/s41232-019-0102-4 · Cited by 34 · see citing works
The generation of hepatocytes from mesenchymal stem cells and engraftment into the liver
Christ, B., & Dollinger, M. (2010) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e3283424f5b · Cited by 34 · see citing works
Raut, A., & Khanna, A. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.03.015 · Cited by 34 · see citing works
Cell therapy in end-stage liver disease: replace and remodel
Hu, X.-H., Chen, L., Wu, H., Tang, Y., Zheng, Q.-M., Wei, X., Wei, Q., Huang, Q., Chen, J., & Xu, X. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03370-z · Cited by 36 · see citing works
- Authors
- Dhawan, A., Puppi, J., Hughes, R. D., & Mitry, R. R.
- Affiliations
- King's College Hospital (GB)
- King's College London (GB)
- Corresponding author
- Dhawan, Anil
- ORCID
- Dhawan, Anil
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2010-04-06
- Volume
- 7
- Issue
- 5
- Pages
- 288-298
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- OpenAlex
- W1999889167
- Cited by
- 362
- References
- 117
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 21 · 2023: 21 · 2022: 22 · 2021: 13 · 2020: 29 · 2019: 31 · 2018: 39 · 2017: 20 · 2016: 18 · 2015: 29 · 2014: 30 · 2013: 29 · 2012: 28
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- hepatocyte transplantation, metabolic liver disease, acute liver failure, organ shortage, stem cell sources, cell therapy, bench-to-bedside translation
- MeSH terms
- Animals, Humans, Treatment Outcome, Liver Failure, Cell Transplantation, Hepatocytes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review