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Cited by 15Photochromic and Fluorescence ChemistryNanoparticle-Based Drug DeliveryPhotopolymerization techniques and applications

Progress in Research of Photo-controlled Drug Delivery Systems

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Zhang, Liuwei, Qian, Ming, Wang, Jingyun·2017·Acta Chimica Sinica
DOI 10.6023/a17050194
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Abstract

The controlled drug delivery systems, due to their precise control of drug release in spatiotemporal level triggered by specific stimulating factors and advantages such as higher utilization ratio of drug, less side-effects to normal tissues and so forth, provide a new strategy for the precise treatment of many serious diseases, especially tumors.The materials that constitute the controlled drug delivery systems are called "smart materials" and they can respond to the stimuli of some internal (pH, redox, enzymes, etc.) or external (temperature, electrical/magnetic, ultrasonic and optical, etc.) environments.Before and after the response to the specific stimulus, the composition or conformational of smart materials will be changed, damaging the original balance of the delivery systems and releasing the drug from the delivery systems.Amongst them, the photo-controlled drug delivery systems, which display drug release controlled by light, demonstrated extensive potential applications, and received wide attention from researchers.In recent years, photo-controlled drug delivery systems based on different photo-responsive groups have been designed and developed for precise photo-controlled release of drugs.Herein, in this review, we introduced four photo-responsive groups including photocleavage groups, photoisomerization groups, photo-induced rearrangement groups and photocrosslinking groups, and their different photo-responsive mechanisms.Firstly, the photocleavage groups represented by O-nitrobenzyl are able to absorb the energy of the photons, inducing the cleavage of some specific covalent bonds.Secondly, azobenzenes, as a kind of photoisomerization groups, are able to convert reversibly between the apolar trans form and the polar cis form upon different light irradiation.Thirdly, 2-diazo-1,2-naphthoquinone as the representative of the photo-induced rearrangement groups will absorb specific photon energy, carrying out Wolff rearrangement reaction.Finally, coumarin is a promising category photocrosslinking groups that can undergo [2＋2] cycloaddition reactions under light irradiation.The research progress of photo-controlled drug delivery systems based on different photo-responsive mechanisms were mainly reviewed.Additionally, the existing problems and the future research perspectives of photo-controlled drug delivery systems were proposed. Keywords photo-responsive; photo

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  • There are four kinds of light sensitive groups: photocleavage group, photoisomerization group, photo-induced rearrangement group, and photocrosslinking group.

    “According to the different light response mechanism, there are four kinds of light sensitive groups: 1) photocleavage group, such as o-nitrobenzyl and coumarin-based groups, etc. 2) photoisomerization group, such as azobenzenes and spiropyran. 3) photo-induced rearrangement group, such as 2-diazo-1,2-naphthoquinone. 4) photocrosslinking group, such as coumarin, cinnamoyl, anthracene, etc.175,176”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [176]

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Authors
Zhang, L., Qian, M., & Wang, J.
Affiliations
Dalian University of Technology (CN)
ORCID
Venue
Acta Chimica Sinica
Publisher
Shanghai Institute of Organic Chemistry
Published
2017
Volume
75
Issue
8
Pages
770
ISSN
0567-7351 (ISSN-L)
DOI
10.6023/a17050194
OpenAlex
W2751741772
Cited by
15
References
7
Citations by year
2026: 2 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2019: 2 · 2018: 1
FWCI
0.35
Type
journal article
Language
en
Open access
Locations
化学学报 (publishedVersion)
Funders
National Natural Science Foundation of China (21376039, U1608222)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Photochromic and Fluorescence Chemistry
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Chemistry › Organic Chemistry › Photopolymerization techniques and applications
Keywords
stimuli-responsive materials, smart materials, azobenzene, photoisomerization, Wolff rearrangement, coumarins, [2+2] cycloaddition, controlled drug release, cancer therapy

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