Prior exercise training and experimental myocardial infarction: a systematic review and meta-analysis
Open accessAbstract
Exercising prior to experimental infarction may have beneficial effects on the heart. The objective of this study was to analyze studies on animals that had exercised prior to myocardial infarction and to examine any benefits through a systematic review and meta-analysis. The databases MEDLINE, Google Scholar, and Cochrane were consulted. We analyzed articles published between January 1978 and November 2018. From a total of 858 articles, 13 manuscripts were selected in this review. When animals exercised before experimental infarction, there was a reduction in mortality, a reduction in infarct size, improvements in cardiac function, and a better molecular balance between genes and proteins that exhibit cardiac protective effects. Analyzing heart weight/body weight, we observed the following results - Mean difference 95% CI - -0.02 [-0.61,0.57]. Meta-analysis of the infarct size (% of the left ventricle) revealed a statistically significant decrease in the size of the infarction in animals that exercised before myocardial infarction, in comparison with the sedentary animals -5.05 [-7.68, -2.40]. Analysis of the ejection fraction, measured by echo (%), revealed that animals that exercised before myocardial infarction exhibited higher and statistically significant measures, compared with sedentary animals 8.77 [3.87,13.66]. We conclude that exercise performed prior to experimental myocardial infarction confers cardiac benefits to animals.
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In preclinical studies, regular exercise prior to MI downregulates proinflammatory, profibrotic, or proapoptotic pathways associated with adverse remodelling.
“There is preclinical evidence that, compared with control group, regular exercise prior to MI reduces infarct size and improves cardiac function (LVEF) as well as the molecular responses (e.g.stress response proteins) involved in heart repair, while downregulating those associated with adverse remodelling (proinflammatory, profibrotic, or proapoptotic pathways).157”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [157]
In preclinical studies, regular exercise prior to MI improves molecular responses involved in heart repair (e.g., stress response proteins).
“There is preclinical evidence that, compared with control group, regular exercise prior to MI reduces infarct size and improves cardiac function (LVEF) as well as the molecular responses (e.g.stress response proteins) involved in heart repair, while downregulating those associated with adverse remodelling (proinflammatory, profibrotic, or proapoptotic pathways).157”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [157]
In preclinical studies, regular exercise prior to MI reduces infarct size compared with control.
“There is preclinical evidence that, compared with control group, regular exercise prior to MI reduces infarct size and improves cardiac function (LVEF) as well as the molecular responses (e.g.stress response proteins) involved in heart repair, while downregulating those associated with adverse remodelling (proinflammatory, profibrotic, or proapoptotic pathways).157”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [157]
In preclinical studies, regular exercise prior to MI improves cardiac function (LVEF) compared with control.
“There is preclinical evidence that, compared with control group, regular exercise prior to MI reduces infarct size and improves cardiac function (LVEF) as well as the molecular responses (e.g.stress response proteins) involved in heart repair, while downregulating those associated with adverse remodelling (proinflammatory, profibrotic, or proapoptotic pathways).157”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [157]
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- Authors
- Veiga, E. C. D. A., Melo, B. L. D., Vieira, S. D. S., Simões, R. S., Valenti, V. E., Campos, M. F., Vale, J. E. T. M. R. D., Rica, R. L., Soares-Júnior, J. M., Baracat, E. C., Serra, A. J., Baker, J. S., & Bocalini, D. S.
- Affiliations
- Universidade de São Paulo (BR)
- Universidade Federal de São Paulo (BR)
- Faculdade de Medicina do ABC (BR)
- Hong Kong Baptist University (HK)
- Universidade Federal do Espírito Santo (BR)
- Corresponding author
- Veiga, Eduardo Carvalho de Arruda
- ORCID
- Venue
- Clinics
- Publisher
- Elsevier BV
- Published
- 2020
- Volume
- 75
- Pages
- e1293
- ISSN
- 1807-5932 (ISSN-L)
- PMC
- PMC6963162
- OpenAlex
- W3004242992
- Cited by
- 14
- References
- 34
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 3 · 2019: 1
- FWCI
- 0.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa e Inovação do Espírito Santo
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- exercise training, myocardial infarction, cardioprotection, infarct size, cardiac function, ejection fraction, heart weight, cardiac gene expression, animal models of heart disease, mortality
- MeSH terms
- Animals, Disease Models, Animal, Female, Heart, Heart Ventricles, Male, Models, Cardiovascular, Myocardial Infarction, Physical Conditioning, Animal, Ventricular Function, Rats, Sprague-Dawley, Rats, Wistar, Mice, Rats
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