The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Significance of Antioxidant Potential of Plants and its Relevance to Therapeutic Applications
Open accessAbstract
Oxidative stress has been identified as the root cause of the development and progression of several diseases. Supplementation of exogenous antioxidants or boosting endogenous antioxidant defenses of the body is a promising way of combating the undesirable effects of reactive oxygen species (ROS) induced oxidative damage. Plants have an innate ability to biosynthesize a wide range of non-enzymatic antioxidants capable of attenuating ROS- induced oxidative damage. Several in vitro methods have been used to screen plants for their antioxidant potential, and in most of these assays they revealed potent antioxidant activity. However, prior to confirming their in vivo therapeutic efficacy, plant antioxidants have to pass through several physiopharmacological processes. Consequently, the findings of in vitro and in vivo antioxidant potential assessment studies are not always the same. Nevertheless, the results of in vitro assays have been irrelevantly extrapolated to the therapeutic application of plant antioxidants without undertaking sufficient in vivo studies. Therefore, we have briefly reviewed the physiology and redox biology of both plants and humans to improve our understanding of plant antioxidants as therapeutic entities. The applications and limitations of antioxidant activity measurement assays were also highlighted to identify the precise path to be followed for future research in the area of plant antioxidants.
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Cites
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Mittler, R. (2002) · Trends in Plant Science · doi:10.1016/s1360-1385(02)02312-9 · Cited by 10,764
The Chemistry behind Antioxidant Capacity Assays
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Cited by
Chromium Bioaccumulation and Its Impacts on Plants: An Overview
Sharma, A., Kapoor, D., Wang, J., Shahzad, B., Kumar, V., Bali, A. S., Jasrotia, S., Zheng, B., Yuan, H., & Yan, D. (2020) · Plants · doi:10.3390/plants9010100 · Cited by 527
Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases
Forni, C., Facchiano, F., Bartoli, M., Pieretti, S., Facchiano, A., D’Arcangelo, D., Norelli, S., Valle, G., Nisini, R., Beninati, S., et al. (2019) · BioMed Research International · doi:10.1155/2019/8748253 · Cited by 513
Antioxidant Capacity Determination in Plants and Plant‐Derived Products: A Review
Pisoschi, A. M., Pop, A., Cimpeanu, C., & Predoi, G. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9130976 · Cited by 304
Toxicity and detoxification of heavy metals during plant growth and metabolism
Dubey, S., Shri, M., Gupta, A., Rani, V., & Chakrabarty, D. (2018) · Environmental Chemistry Letters · doi:10.1007/s10311-018-0741-8 · Cited by 293
Ashraf, M. V., Khan, S., Misri, S., Gaira, K. S., Rawat, S., Rawat, B., Khan, M. A. H., Shah, A. A., Asgher, M., & Ahmad, S. (2024) · Pharmaceuticals · doi:10.3390/ph17080975 · Cited by 102
Metadata
- Authors
- Kasote, D. M., Katyare, S. S., Hegde, M. V., & Bae, H.
- Venue
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2015
- Volume
- 11
- Issue
- 8
- Pages
- 982-991
- ISSN
- 1449-2288 (ISSN-L)
- OpenAlex
- W1526856981
- Cited by
- 1,112
- References
- 95
- FWCI
- 27.88
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kasote, D. M., Katyare, S. S., Hegde, M. V., & Bae, H. (2015). Significance of Antioxidant Potential of Plants and its Relevance to Therapeutic Applications. International Journal of Biological Sciences. https://doi.org/10.7150/ijbs.12096
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
