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Cited by 102Phytochemicals and Antioxidant ActivitiesAntioxidant Activity and Oxidative StressMedicinal Plant Research

High-Altitude Medicinal Plants as Promising Source of Phytochemical Antioxidants to Combat Lifestyle-Associated Oxidative Stress-Induced Disorders

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Ashraf, Mohammad Vikas, Khan, Sajid, Misri, Surya, Gaira, Kailash S., Rawat, Sandeep, Rawat, Balwant, Khan, M. A. Hannan, Shah, Ali Asghar +2 more·2024·Pharmaceuticals
DOI 10.3390/ph17080975PMC PMC11357401
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Abstract

Oxidative stress, driven by reactive oxygen, nitrogen, and sulphur species (ROS, RNS, RSS), poses a significant threat to cellular integrity and human health. Generated during mitochondrial respiration, inflammation, UV exposure and pollution, these species damage cells and contribute to pathologies like cardiovascular issues, neurodegeneration, cancer, and metabolic syndromes. Lifestyle factors exert a substantial influence on oxidative stress levels, with mitochondria emerging as pivotal players in ROS generation and cellular equilibrium. Phytochemicals, abundant in plants, such as carotenoids, ascorbic acid, tocopherols and polyphenols, offer diverse antioxidant mechanisms. They scavenge free radicals, chelate metal ions, and modulate cellular signalling pathways to mitigate oxidative damage. Furthermore, plants thriving in high-altitude regions are adapted to extreme conditions, and synthesize secondary metabolites, like flavonoids and phenolic compounds in bulk quantities, which act to form a robust antioxidant defence against oxidative stress, including UV radiation and temperature fluctuations. These plants are promising sources for drug development, offering innovative strategies by which to manage oxidative stress-related ailments and enhance human health. Understanding and harnessing the antioxidant potential of phytochemicals from high-altitude plants represent crucial steps in combating oxidative stress-induced disorders and promoting overall wellbeing. This study offers a comprehensive summary of the production and physio-pathological aspects of lifestyle-induced oxidative stress disorders and explores the potential of phytochemicals as promising antioxidants. Additionally, it presents an appraisal of high-altitude medicinal plants as significant sources of antioxidants, highlighting their potential for drug development and the creation of innovative antioxidant therapeutic approaches.

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  • The formation of copper deposits requires electron donation from a metallic reducing agent.

    “These findings confirm that the formation of copper deposits requires electron donation from a metallic reducing agent [34], [35], [36], [37].”

    From Identification of the Redox Reaction Between CuSO₄ and Zn Through Visual Observation in Basic Chemistry (2026) · cites this paper as [34]

    The Introduction (§1.1.2) discusses electron transfer in mitochondrial ROS production, while §2 describes phytochemicals transferring electrons to neutralize radicals. Neither passage addresses copper deposits or a requirement for electron donation from a metallic reducing agent; searches for copper deposition and metallic reducing agents found no supporting passage in our copy. Page numbers were not available. (LLM, conf=0.74)

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Authors
Ashraf, M. V., Khan, S., Misri, S., Gaira, K. S., Rawat, S., Rawat, B., Khan, M. A. H., Shah, A. A., Asgher, M., & Ahmad, S.
Affiliations
  • Baba Ghulam Shah Badshah University (IN)
  • G.B. Pant Institute of Himalayan Environment and Development (IN)
  • Graphic Era University (IN)
Corresponding author
  • Asgher, Mohd
  • Ahmad, Shoeb
ORCID
Venue
Pharmaceuticals
Publisher
MDPI AG
Published
2024-07-23
Volume
17
Issue
8
Pages
975
ISSN
1424-8247 (ISSN-L)
DOI
10.3390/ph17080975
PMC
PMC11357401
OpenAlex
W4400983985
Cited by
102
References
419
Citations by year
2026: 51 · 2025: 50 · 2024: 1
FWCI
3.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Pharmaceuticals (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
University Grants Commission, New Delhi, India (F 30-459/2019(BSR))
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
oxidative stress, reactive oxygen species, reactive nitrogen species, reactive sulfur species, flavonoids, phenolic compounds, carotenoids, tocopherols, vitamin C, mitochondrial reactive oxygen species, ultraviolet radiation, lifestyle-related diseases, drug development, antioxidant defense

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