The PI3K/AKT pathway in obesity and type 2 diabetes

Huang, Xingjun, Liu, Guihua, Guo, Jiao, Su, Zhengquan·2018·International Journal of Biological Sciences

Cited by (1,008)

Items 401–500 of 1,008

  1. Advanced glycation end products: understanding their health risks and effective prevention strategies
    Burak Erim, Halil İbrahim Binici · 2024 · Nutrire
  2. Oligosaccharides of Ophiopogon japonicus ameliorate insulin resistance and glucolipid metabolism in HFD/STZ-induced T2DM rats and IR-HepG2 cells via activation of the IRS-1/PI3K/AKT/GSK-3β pathway
    Bao-Ting Chen, Zilin Li, Jia Fang, Yiming Liu, Ai-Hua Lin · 2024 · Journal of Functional Foods
  3. Multi-Omics Analysis Revealed the rSNPs Potentially Involved in T2DM Pathogenic Mechanism and Metformin Response
    Igor S. Damarov, Elena E. Korbolina, ELENA YU. RYKOVA, Tatiana I. Merkulova · 2024 · International Journal of Molecular Sciences
  4. Allantoin reduces glucotoxicity and lipotoxicity in a type 2 diabetes rat model by modulating the PI3K and MAPK signaling pathways
    Yao Zhao, Ming Qiao, Xiao-Mei Wang, Xinjie Luo, Jian-Hua Yang, Jun-Ping Hu · 2024 · Heliyon
  5. A PNPLA3-Deficient iPSC-Derived Hepatocyte Screen Identifies Pathways to Potentially Reduce Steatosis in Metabolic Dysfunction-Associated Fatty Liver Disease
    Caren Doueiry, Christiana S. Kappler, Carla Martinez-Morant, Stephen A. Duncan · 2024 · International Journal of Molecular Sciences
  6. Combination of plant metabolites hinders starch digestion and glucose absorption while facilitating insulin sensitivity to diabetes
    Xin Huang, Kai-Huang Lin, Si-Nian Liu, Junxiong Yang, Hao-Yu Zhao, Xiao-Hui Zheng, May-Jywan Tsai, Chun-Sheng Chang, Li-Yue Huang, Ching-Feng Weng · 2024 · Frontiers in Pharmacology
  7. Therapeutic potential and pharmacological mechanism of visnagin
    Poonam Yadav, Sumeet Kumar Singh, Sayantap Datta, Saloni Verma, Aarti Verma, Arnab Rakshit, Anjana Bali, Jasvinder Singh Bhatti, Amit Khurana, Umashanker Navik · 2024 · Journal of Chinese Integrative Medicine
  8. Assessing the possible association between MTHFR (rs1801133) and GPx-1 (rs1050450) polymorphisms with the risk of type 2 diabetes, diabetic neuropathy, and diabetic retinopathy
    Soheila Asadi, Z. Rahimi, M. Kohsari, Fateme Babajani, M. Amiri, Nazanin Jalilian, R. Naseri, L. Haghnazari · 2024 · Molecular Biology Reports
  9. Foam dressing and micropower vacuum dressing promote diabetic foot ulcer wound healing by activating the PI3K/AKT/mTOR pathway in rats
    Cunren Chen, Qianying Ou, Kaining Chen, Changli Liang, Xiaocui Zeng, Danhong Lin, Lu Lin · 2024 · Journal of Biomaterials Applications
  10. Pregnane X receptor knockout mitigates weight gain and hepatic metabolic dysregulation in female C57BL/6 J mice on a long-term high-fat diet
    Lidya H Gebreyesus, Sora Choi, Prince Neequaye, Mattia A. Mahmoud, Mia Mahmoud, Malvin Ofosu‐Boateng, Elizabeth Twum, Daniel Okwudili Nnamani, Lijin Wang, Nour Yadak et al. · 2024 · Biomedicine & Pharmacotherapy
  11. Exploring the Anti-Diabetic Potential of Quercetagitrin through Dual Inhibition of PTPN6 and PTPN9
    Geetanjali B. Gone, Geonhui Go, Gibeom Nam, Woojoo Jeong, Hye Min Kim, Soah Lee, Sang Jeon Chung · 2024 · Nutrients
  12. Decoding the alpha-amylase inhibitory activity of Garcinia indica Choisy by computational and experimental studies
    Faizan A. Beerwala, Shruti V. Kolambkar, Vishal S. Patil, Darasaguppe Ramachandra Harish, Nayeem Ashrafali Khatib, Vishwambhar Vishnu Bhandare, Harsha Vasudev Hegde, Subarna Roy · 2023 · South African Journal of Botany
  13. Characterization of palmitic acid toxicity induced insulin resistance in HepG2 cells.
    Sajad Malik, Shrirang Inamdar, Jhankar D. Acharya, Pranay Goel, Saroj Ghaskadbi · 2024 · Toxicology in Vitro
  14. Flavonoids from Lophatherum gracile Brongn. Ameliorate Liver Damages in High-Fat Diet and Streptozotocin-Induced Diabetic Mice by Regulating PI3K/AKT and NF-Kappa B Pathways
    Jian-Hua Zheng, Song‐Xia Lin, X. Li, Chunyan Shen, Shaowei Zheng, Wen-Bin Chen · 2023 · Journal of Food Biochemistry
  15. Anti-Diabetic Potential of Sargassum horneri and Ulva australis Extracts In Vitro and In Vivo
    Young-Hyeon Lee, Hye-Ran Kim, Min‐Ho Yeo, Sung-Chun Kim, Ho Bong Hyun, Young‐Min Ham, Yong‐Hwan Jung, Hye‐Sook Kim, Kyung-Soo Chang · 2023 · Current Issues in Molecular Biology
  16. Chromogranin A and its derived peptides: potential regulators of cholesterol homeostasis
    Dhanya R. Iyer, Janani Venkatraman, Émeline Tanguy, Nicolas Vitale, Nitish R. Mahapatra · 2023 · Cellular and Molecular Life Sciences
  17. Implications on growth performance, glucose metabolism, PI3K/AKT pathway, intestinal flora induced by dietary taurine in a high-carbohydrate diet for grass carp (Ctenopharyngodon idella)
    Ling Pan, Jiahao Qian, Hongyu Liu, Beiping Tan, Xiaohui Dong, Qihui Yang, Shuyan Chi, Shuang Zhang · 2023 · British Journal Of Nutrition
  18. Differential network analysis between sex of the genes related to comorbidities of type 2 mellitus diabetes
    Pietro Hiram Guzzi, Francesca Cortese, Gaia Chiara Mannino, Elisabetta Pedace, Elena Succurro, Francesco Andreozzi, Pierangelo Veltri · 2023 · Applied Network Science
  19. MiR-93-5p inhibits retinal neurons apoptosis by regulating PDCD4 in acute ocular hypertension model
    Cheng Tan, Wenjia Shi, Yun Zhang, Can Liu, Tu Hu, Dan Chen, Jufang Huang · 2023 · Life Science Alliance
  20. Exploring the pharmacological mechanisms of Tripterygium wilfordii against diabetic kidney disease using network pharmacology and molecular docking
    Meiqi Lu, Juanjuan Ou, Xiaoqi Deng, Yixuan Chen, Qing Gao · 2023 · Heliyon
  21. Estrogen-mediated oar-miR-485-5p targets PPP1R13B to regulate myoblast proliferation in sheep
    Siqi Liu, Ziyi Liu, Peng Wang, Wentao Li, Shengguo Zhao, Yufang Liu, Mingxing Chu · 2023 · International Journal of Biological Macromolecules
  22. The significant antidyslipidemic, hypoglycemic, antihyperglycemic, and antiobesity activities of the aqueous extracts of Agave Sisalana juice are partly mediated via modulation of calcium signaling pathways
    Boniface Mwangi Chege, Nelly Murugi Nyaga, Prabjot K. Sehmi, Wycliffe Odhiambo Misigo, Nelson Khan, Wycliffe Chisutia Wanyonyi, Peter Waweru Mwangi · 2022 · Heliyon
  23. Dietary n-3 and n-6 polyunsaturated fatty acids differentially modulate the adiponectin and leptinmediated major signaling pathways in visceral and subcutaneous white adipose tissue in high fat diet induced obesity in Wistar rats.
    Prerna Sharma, Chetna Bhandari, N. Agnihotri · 2022 · Nutrition Research
  24. Investigating the Mechanism of Rhizoma Coptidis-Eupatorium fortunei Medicine in the Treatment of Type 2 Diabetes Based on Network Pharmacology and Molecular Docking
    Huan Li, Dan Luo, Ran Wei, Mingliang Sun, Xi Zhang, Huan Deng, W. Bian, Haoyue Wei, Yan-Qin Huang · 2022 · BioMed Research International
  25. Anti-type 2 diabetes mellitus mechanisms and structural characteristics of polysaccharides: A review
    Yuanhao Qiu, Yufei Wang, Anning Song, Chenxi Li, Ruixi Zhang, Liren Ma, Xinhua Zheng, Weiwei Fan, Huashan Gao · 2026 · Carbohydrate Research
  26. Targeting the PI3K/AKT signaling pathway: an important molecular mechanism of herbal medicine in the treatment of MASLD/MASH
    Shan Jiang, Li Zhai, Yingchun Shao, Fusheng Sun, Xuedong Liu · 2026 · Frontiers in Nutrition
  27. Hesperidin Inhibits Oxidative Stress and Apoptosis of Granulosa Cells in Polycystic Ovarian Syndrome Through the JAK2/STAT3 and PI3K/AKT Pathways
    Qi-Xuan Zhang, Zhe Yang, Xiang-Yang Ou, Meng-Ying Zhang, Rui-Cheng Ji, Geng-Xiang Wu · 2025 · Phytotherapy Research
  28. Advances in supplementation strategies for enhancing bovine in vitro embryo production: a review of growth factors and antioxidants
    O. Kereilwe · 2025 · Journal of Assisted Reproduction and Genetics
  29. The effects of cynaroside on lipid metabolism and lipid-related diseases: a mechanistic overview
    Chenyi Cen, Jiahuan Li, Pu Zhou, David P. Fisher, Nguyễn Thị Thu Hiền, Erkin Isakovich Musabaev, Khrystyna Pronyuk, Lei Zhao · 2025 · Frontiers in Pharmacology
  30. Unraveling novel mechanisms of ATP-Binding cassette (ABC) transporter in insulin Resistance-induced amyloidogenesis
    AKHIL KUMAR SHARMA, Ashi Mannan, Thakur Gurjeet Singh · 2025 · Metabolic Brain Disease
  31. Elucidating the Anti-Diabetic Mechanisms of Mushroom Chaga (Inonotus obliquus) by Integrating LC-MS, Network Pharmacology, Molecular Docking, and Bioinformatics
    Nidesha Randeni, Jinhai Luo, Yingzi Wu, Baojun Xu · 2025 · International Journal of Molecular Sciences
  32. Mechanism of liver x receptor alpha in intestine, liver and adipose tissues in metabolic associated fatty liver disease
    Kaiwen Lei, Yan Chen, Jian‐Xing Wu, Yiyu Lin, Yan Bai, Hua Cao, Qishi Che, Jiao Guo, Zhengquan Su · 2025 · International Journal of Biological Macromolecules
  33. DUSP9-mediated inhibition of IRS1/PI3K/AKT pathway contributes to insulin resistance and metabolic dysfunction in gestational diabetes mellitus.
    Xiaomin Zhang, Yanqi Jin · 2025 · Human Immunology
  34. Flavonoid-Rich Extracts from Chuju (Asteraceae Chrysanthemum L.) Alleviate the Disturbance of Glycolipid Metabolism on Type 2 Diabetic Mice via Modulating the Gut Microbiota
    Yu Yin, Wen Nie, Zheng-Quan Tang, Shuang-Jie Zhu · 2025 · Foods
  35. Low Temperature Plasma Jet Treatment Promotes Skin Wound Healing by Enhancing Cell Proliferation via the PI3K‐AKT and AMPK Pathways
    Yue-Han Zhu, Xin-Rong Lian, Kai Li, Jing-Yao Zhang, Wen-Jing Wu, Xinhua Zhang, Jin Zhang · 2025 · International Wound Journal
  36. Algal Active Ingredients and Their Involvement in Managing Diabetic Mellitus
    Aijun Tong, Dengwei Wang, Nan Jia, Ying Zheng, Yusong Qiu, Weichao Chen, Hesham R. El-Seed, Chao Zhao · 2024 · Biology
  37. Alpelisib-Induced Diabetic Ketoacidosis and Insulin-Resistant Hyperglycemia
    M. Loke, Vishal Sehgal, Niraj Gupta · 2024 · AACE Clinical Case Reports
  38. Investigation of the Pharmacodynamic Components of Gastrodia elata Blume for Treatment of Type 2 Diabetes Mellitus through HPLC, Bioactivity, Network Pharmacology and Molecular Docking
    Xiu Yang, Li-Lang Li, Yan-Fang Yan, Xuehao Hu, Qi-Ji Li, Liang-Qun Li, Yu Wang, Xian Tao, Li-shou Yang, Mei Peng et al. · 2024 · International Journal of Molecular Sciences
  39. Single-Atom Ce-N-C Nanozyme Ameliorates Type 2 Diabetes Mellitus by Improving Glucose Metabolism Disorders and Reducing Oxidative Stress
    Yitong Lin, Yanan Wang, Qi Zhang, Ruxin Gao, Fei Chang, Boran Li, Kunlun Huang, Nan Cheng, Xiaoyun He · 2024 · Biomolecules
  40. Unveiling the bioinformatic genes and their involved regulatory mechanisms in type 2 diabetes combined with osteoarthritis
    Guangming Mao, Wen-hao Xu, Lingli Wan, Hong-Ping Wang, Shutao Xu, Liangming Zhang, Shiyang Li, Jifa Zhang, Zhong-ming Lai, Yuping Lan et al. · 2024 · Frontiers in Immunology
  41. Hydrolysable tannin improves growth performance and liver health of largemouth bass (Micropterus salmoides) fed high soybean meal diets
    Manqi Yang, Dahai Jiang, Weibin Lai, Kai Chen, Liangliang Zhang, Liming Lu, Yong Xu, Yiwen Liu, Mohd Shariq Khan, Jianchun Jiang · 2024 · International Journal of Biological Macromolecules
  42. The effect of curcumin on PI3K/Akt and AMPK pathways in insulin resistance induced by fructose
    Gülce Kiren, Çınar Severcan, Suzan MURATOĞLU SEVERCAN, Hatîce Paşaoğlu · 2024 · Turkish Journal of Biochemistry
  43. microRNA Expression Profile in Obesity-Induced Kidney Disease Driven by High-Fat Diet in Mice
    Àuria Eritja, Maite Caus, Thalía Belmonte, D. de Gonzalo-Calvo, A. García-Carrasco, Ana Martinez, Montserrat Martínez, M. Bozic · 2024 · Nutrients
  44. Glucosamine substituted sulfonylureas: IRS-PI3K-PKC-AKT-GLUT4 insulin signalling pathway intriguing agent.
    G. Suaifan, B. Alkhawaja, Mayadah B. Shehadeh, Mridula Sharmaa, Chan Hor Kuan, P. Okechukwu · 2024 · RSC Medicinal Chemistry
  45. 1H NMR metabolomics insights into comparative diabesity in male and female zebrafish and the antidiabetic activity of DL-limonene
    Khaled Benchoula, C. Serpell, A. Mediani, Abdulaziz Albogami, Norazlan Mohmad Misnan, Nor Hadiani Ismail, I. Parhar, Satoshi Ogawa, Wong Eng Hwa · 2024 · Scientific Reports
  46. Inhibition of PTEN promotes osteointegration of titanium implants in type 2 diabetes by enhancing anti-inflammation and osteogenic capacity of adipose-derived stem cells
    Guanhua Zhang, Shuang Song, Zijun Chen, Xiangdong Liu, Jian Zheng, Yuxi Wang, Xutao Chen, Yingliang Song · 2024 · Frontiers in Bioengineering and Biotechnology
  47. Investigation on the antipyretic mechanism of Chaiqin Qingning capsule for the treatment of fever based on network pharmacology, molecular docking, and in vitro experimental validation
    Lian-Zhan Huang, Zhengwei Chen, Hong-Jin Gao, Zhen Wang, Xuan-Sheng Ding · 2024 · Chemical Biology & Drug Design
  48. Impact of “Golden” tomato juice on cognitive alterations in metabolic syndrome: Insights into behavioural and biochemical changes in a high-fat diet rat model
    Giuditta Gambino, Monica Frinchi, Giuseppe Giglia, Miriana Scordino, Giulia Urone, Giuseppe Ferraro, Giuseppa Mudò, Pierangelo Sardo, Danila Di Majo, Valentina Di Liberto · 2023 · Journal of Functional Foods
  49. Chlormequat chloride induced activation of calmodulin mediated PI3K/AKT signaling pathway led to impaired sperm quality in pubertal mice.
    Xiaoxia Wang, Chenping Kang, Wanqian Guo, Lilan Yuan, Haoran Zhang, Qiong Zhang, Qianqian Xiao, Wei-Dong Hao · 2024 · Food and Chemical Toxicology
  50. The role of miR-143/miR-145 in the development, diagnosis, and treatment of diabetes
    Yousef Rasmi, Yara Ahmed Mohamed, Shahriar Alipour, Salma Ahmed, Samar Samir Abdelmajed · 2023 · Journal of Diabetes & Metabolic Disorders
  51. The 15-hydroxyprostaglandin dehydrogenase inhibitor SW033291 ameliorates abnormal hepatic glucose metabolism through PGE2–EP4 receptor–AKT signaling in a type 2 diabetes mellitus mouse model
    Mingjie Liang, Lexun Wang, Weixuan Wang · 2023 · Cellular Signalling
  52. The Crosstalk and Clinical Implications of CircRNAs and Glucose Metabolism in Gastrointestinal Cancers
    Xiaonuan Luo, Yin Peng, Xinmin Fan, Xiaoxun Xie, Zhe Jin, Xiaojing Zhang · 2023 · Cancers
  53. The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice
    María Jesús Rodríguez‐Sojo, Antonio Jesús Ruiz‐Malagón, Laura Hidalgo‐Garcia, José Alberto Molina‐Tijeras, Patricia Diez‐Echave, Laura López-Escánez, Lucrezia Rosati, Elena González-Lozano, Laura Cenis-Cifuentes, Jorge García-García et al. · 2023 · Antioxidants
  54. Taraxasterol Inhibits Hepatic Gluconeogenesis and Increases Glycogen Synthesis via the PI3K/Akt Signaling Pathway
    Mao Zhao, Mingxing Lu, Yongjiang Zeng, Shasha He, Yuhan Feng, Songqin Yang, Wen-Wen Jang · 2023 · Natural Product Communications
  55. Reduction of Obesity and Insulin Resistance through Dual Targeting of VAT and BAT by a Novel Combination of Metabolic Cofactors
    Sergio Quesada‐Vázquez, Anna Antolín, Marina Colom‐Pellicer, Gerard Aragonès, Laura Herrero, Josep M Del Bas-Prior, Antoni Caimari, Xavier Escoté · 2022 · International Journal of Molecular Sciences
  56. Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet-induced obese male mice
    Annayya Rao Aroor, Vincent Gerard DeMarco, Adam T. Whaley‐Connell, Guanghong Jia, Yan Yang, Neekun Sharma, Huma Naz, Chetan Parkash Hans, Melvin Ray Hayden, Michael A. Hill et al. · 2022 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  57. Systems pharmacology‐based drug discovery and active mechanism of phlorotannins for type 2 diabetes mellitus by integrating network pharmacology and experimental evaluation
    Jialiang Chen, Ping Li, Shuhong Ye, Wei Li, Ming Li, Yan Ding · 2022 · Journal of Food Biochemistry
  58. Reduction in Insulin Mediated ERK Phosphorylation by Palmitate in Liver Cells Is Independent of Fatty Acid Induced ER Stress
    Sindiyan Al Shaikh Mubarak, Abeer Al Otaibi, Ali Ahmed Al Qarni, Ahmed Bakillah, Jahangir Iqbal · 2022 · Nutrients
  59. In vitro skeletal muscle models for type 2 diabetes
    Christina Y. Sheng, Young Hoon Son, Jeongin Jang, Sung‐Jin Park · 2022 · Biophysics Reviews
  60. Dietary phytochemicals as multitarget strategies against metabolic syndrome: Mechanistic basis and translational outlook
    Yogi Simanjuntak, Princella Halim, Nurpudji Astuti Taslim, Fahrul Nurkolis, Arya Tjipta Prananda, Aminah Dalimunthe, Satirah Zainalabidin, Nur Aira Juwita, Alexander Patera Nugraha, Tjandrawinata RR et al. · 2026 · Food Chemistry Advances
  61. Antidiabetic effects of Agaricus bisporus polysaccharide in HFD/STZ-induced mice
    Ziyang Wang, Qinqin Ouyang, Haiying Guo, Hongxia Li, Rong Liu · 2026 · International Journal of Biological Macromolecules
  62. Resistance Exercise Counteracts Skeletal Muscle Atrophy in T2DM Mice by Upregulating FGF21 and Activating PI3K/Akt Pathway
    Xiaojie Ma, Zhijian Rao, Zhihai Jin, Yibing Lu, Zhitong Sun, Lifang Zheng · 2025 · Biomolecules
  63. Andrographolide alleviates type 2 diabetic nephropathy through suppressing PI3K/AKT1/RRM2-triggered oxeiptosis
    Mingzheng Han, Jingchun Wang, Shuaihao Guo, Heyun Zhu, Lijiao Zhao, Ziqi Wu, Yijin Wu, Jianying Guo, Jianzhao Liao, Zhaoxin Tang · 2025 · Journal of Advanced Research
  64. TRAF7 protects against acute lung injury by promoting K6-linked ubiquitination of AKT.
    Jia Wang, Mengliu Zeng, Yazhou Sun, Xu-Tao Zhang, Xinyu Li, Wei Qu, Wei Li, Jia-Yi Liu, Xu Cheng, Jun Zhang et al. · 2025 · Science Bulletin
  65. Anti-Diabetic Effect of Soy–Whey Dual-Protein on Mice with Type 2 Diabetes Mellitus Through INS/IRS1/PI3K Signaling Pathway
    Na Li, Hu Li, Duo Feng, Mengjie Li, Di Han, Tianxin Liu, Jing Wang · 2025 · Foods
  66. Impact of age on cardiometabolic health in children at adiposity rebound: the role of genetic mechanisms
    Ling Luo, Fangbiao Tao · 2025 · World Journal of Pediatrics
  67. Obesity-driven hunger: From pathophysiology to intervention
    Ahmad Khusairi Azemi, Yahkub Babatunde Mutalub, Monsurat Abdulwahab, Aida Hanum Ghulam Rasool, Sagir Mustapha, Siti Qusyasyiah Ahmad Suhaimi, Siti Safiah Mokhtar · 2025 · Obesity Medicine
  68. CDK1-loaded extracellular vesicles promote cell cycle to reverse impaired wound healing in diabetic obese mice
    Wooil Choi, Dong Jun Park, Robert A. Dorschner, Keita Nakatsutsumi, Michelle Yi, Brian P. Eliceiri · 2025 · Molecular Therapy
  69. RS4 Type Resistant Starch Improves Type 2 Diabetes Mellitus in Mice by Interacting With Lactobacillus johnsonii
    Tao Xu, Yongheng Zhong, Shengyang Ji, Hang Xiao, Jun Li, Kaimian Li, Peiwu Li, Baiyi Lu · 2024 · Food Frontiers
  70. Metabolite Profiling and Integrated Network Pharmacology Based Mechanism of Benincasa hispida (Thunb.) Cogn. Fruit Against Non-insulin-Dependent Diabetes Mellitus.
    B. Das Gupta, Amit Kar, Seha Singha, Srijon Gayen, Sandipan Jana, Nanaocha Sharma, P. Haldar, P. K. Mukherjee · 2024 · Phytochemical Analysis
  71. Hesperetin-copper (II) complex improves liver glucose metabolism by regulating the IRS-1/PI3K/AKT signaling pathway in T2DM mice
    Xi Peng, Yushi Wei, De-Ming Gong, Guo-Wen Zhang · 2024 · Food Bioscience
  72. Artificial Gravity Attenuates the Transcriptomic Response to Spaceflight in the Optic Nerve and Retina
    Isaac J. Kremsky, Reyna Pergerson, Stephen Justinen, Seta Stanbouly, Jeffrey S. Willey, Charles A Fuller, Satoru Takahashi, M. Vitaterna, M. Bouxsein, Xiao W. Mao · 2024 · International Journal of Molecular Sciences
  73. Metformin Prevents Tumor Cell Growth and Invasion of Human Hormone Receptor-Positive Breast Cancer (HR+ BC) Cells via FOXA1 Inhibition
    Christine Song, Dawa Jung, Ayse Tuba Kendi, Jin Kyung Rho, Eun-Joo Kim, Ian Horn, Geoffry L. Curran, Sujala Ghatamaneni, Ji Yeon Shim, Pil Soo Kang et al. · 2024 · International Journal of Molecular Sciences
  74. Microcystin-RR promote lipid accumulation through CD36 mediated signal pathway and fatty acid uptake in HepG2 cells.
    W. Jia, Lin Zhong, Qingmiao Ren, Da Teng, Lei Gong, Hai-Bin Dong, Jun Li, Chun-Xiao Wang, Yong He, Jun Yang · 2024 · Environmental Research
  75. Establishment of diabetes mellitus model using Bombyx mori silkworms in a low-temperature environment.
    Jiaming Hou, Cheng Tan, Nan Chen, Yuan Zhou, Shaojun Huang, Hua-Ni Chen, Li Qian · 2024 · Archives of Insect Biochemistry and Physiology
  76. Antidiabetic Effect of Fermented Mesembryanthemum crystallinum L. in db/db Mice Involves Regulation of PI3K-Akt Pathway
    Hye-Lin Kim, Yunu Jung, Hyo In Kim, Nak‐Yun Sung, Min-Jee Kim, In-Jun Han, Geon Kim, Eun Yeong Nho, Sang-Yun Park, Yohan Han et al. · 2023 · Current Issues in Molecular Biology
  77. miR-499a rs3746444 A>G Polymorphism Is Correlated with Type 2 Diabetes Mellitus and Diabetic Polyneuropathy in a Romanian Cohort: A Preliminary Study
    Emilia Burada, Maria-Magdalena Roșu, Raluca Elena Sandu, Florin Burada, Mihai Cucu, Ioana Streață, Bianca Petre-Mandache, Gabriela Popescu‐Hobeanu, Monica-Laura Cara, Anca-Maria Țucă et al. · 2023 · Genes
  78. The Effect of Hormones Insulin and Glucagon on Ubiquitin Modifications Elucidated by Proteomics in Liver Cells
    Hari Priya Vemana, Vikas V. Dukhande · 2023 · Life Sciences
  79. Identification of XAF1 as an endogenous AKT inhibitor
    Min Chen, Kangjunjie Wang, Ying Han, Shukun Yan, Huairui Yuan, Qiuli Liu, Long Li, Ni Li, Hongwen Zhu, Dayun Lu et al. · 2023 · Cell Reports
  80. Transcriptome-Based Traits of Radioresistant Sublines of Non-Small Cell Lung Cancer Cells
    Margarita V. Pustovalova, Philipp Malakhov, Anastasia Guryanova, Maxim Sorokin, Maria Suntsova, Anton A. Buzdin, Andreyan Nikolaevich Osipov, Sergey V. Leonov · 2023 · International Journal of Molecular Sciences
  81. Adiponectin receptors activation performs dual effects on regulating myogenesis and adipogenesis of young and aged muscle satellite cells
    Shibo Liu, Hanghang Liu, Yao Liu, Ju Zhang, Zhikai Liu, Zizhuo Zheng, En Luo · 2022 · Cell Proliferation
  82. A Network-Pharmacology-Combined Integrated Pharmacokinetic Strategy to Investigate the Mechanism of Potential Liver Injury due to Polygonum multiflorum
    Z. Jia, Li-Rong Liu, Cong Fang, M. Pan, Shi-Yu Cong, Zhong-Hui Guo, Xiao-Qin Yang, Jie Liu, Yue-Ting Li, H. Xiao · 2022 · Molecules
  83. Zishen Pill alleviates diabetes in Db/db mice via activation of PI3K/AKT pathway in the liver
    You Wu, Bo-ju Sun, Xiao-Yuan Guo, Li-Li Wu, Yaomu Hu, Ling-Ling Qin, Tao Yang, Mei Li, Tian-Yu Qin, Miao Jiang et al. · 2022 · Chinese Medicine
  84. Effects of two triterpenoids from Nigella sativa seeds on insulin resistance of 3T3-L1 adipocytes
    Jin-Feng Wei, Baoguang Wang, Yi-Xiao Chen, Qiu-Yi Wang, A. F. Ahmed, L. Cui, Xue-Feng Xi, Wenyi Kang · 2022 · Frontiers in Nutrition
  85. Picralima nitida leaf extract ameliorates oxidative stress and modulates insulin signaling pathway in high fat-diet/STZ induced diabetic rats
    I. Folorunso, Femi Olawale, Kolawole Olofinsan, O. Iwaloye · 2022 · South African Journal of Botany
  86. Statistical Bioinformatics to Uncover the Underlying Biological Mechanisms That Linked Smoking with Type 2 Diabetes Patients Using Transcritpomic and GWAS Analysis
    Abu Sayed Md. Ripon Rouf, Md. Al Amin, Md. Khairul Islam, F. Haque, Kazi Rejvee Ahmed, Md. Ataur Rahman, M. Islam, Bonglee Kim · 2022 · Molecules
  87. Oxoaporphine-Metformin Rhodium(III) Mixed Complex Achieving Dual Antidiabetes and Anticancer Effects by Interfering with Glucose Metabolism Reprogramming.
    Kun Yang, Qi-Yuan Yang, Kai Yang, Wu-Yan Hou, Juan Chen, Qian Chen, Yun-Qiong Gu, M. I. Choudhary, Hong Liang, Zhen-Feng Chen · 2025 · Journal of the American Chemical Society
  88. Epigenetic alterations in obstructive sleep Apnea: a pooled analysis of DNA methylation profiles in humans and animal models
    E. Engal, A. Gileles-Hillel · 2025 · Clinical Epigenetics
  89. Role of Nitric Oxide and Nrf2 to Counteract Vascular Endothelial Dysfunction Induced by Periodontal Pathogens Using HUVECs
    G. Dhungana, C. Sampath, Vineeta D. Sharma, Olga Y. Korolkova, P. Gangula · 2025 · Cells
  90. Mitigation of thromboinflammation by rivaroxaban ameliorates metabolic and structural manifestations of metabolic dysfunction-associated steatohepatitis in rats: Comparison to other antithrombotic drugs.
    Basant Rageh, Marium M. Shamaa, Mahmoud A Agami, A. El-Yazbi, Ahmed Wahid · 2025 · Journal of Pharmacology and Experimental Therapeutics
  91. Amelioration of diabetic myopathy by APMCG-1: A mountain-cultivated ginseng-derived glycopeptide evaluated in zebrafish and mouse models
    Feng Liu, Jiong Chen, Tongchuan Wu, Hongkan Xu, Shujie Zhuang, Xirao Ma, Hao Yue, Yulin Dai · 2025 · Journal of Ethnopharmacology
  92. Research progress on the pathogenesis, clinical impact, and traditional Chinese medicine treatment of polycystic ovary syndrome complicated by insulin resistance
    Zepu Sun, Bao Jin, Han Han, Zhen Qin, Yuqian Shi, Yuehui Zhang · 2025 · Frontiers in Pharmacology
  93. Beyond base camp: PI3K/mTOR inhibition for the treatment of pediatric high-grade gliomas
    Ryan J. Duchatel, Clara Savary, Zacary P. Germon, Madisen Riley, David Simon Ziegler, Sabine Mueller, Evangeline R. Jackson, Matthew D. Dun · 2025 · Neuro-Oncology
  94. Lycopene alleviates high carbohydrate diet induced hepatic steatosis in black seabream (Acanthopagrus schlegelii): Potential for nutritional intervention
    Xinyan Zhi, Yixin Gu, Yangguang Bao, Wenli Zhao, Xuran Liu, Jiayun Zhu, Hao Cheng, Dingqi Mao, Tingting Zhu, Peng Sun et al. · 2025 · Aquaculture Reports
  95. Thiram-driven XBP1 and CHOP pathways orchestrate ER stress and avian tibial dyschondroplasia via metabolic inflammatory axis.
    S. Nawaz, Muhammad Farhan Rahim, Khodja Salaheddine, H. Ur Rehman, Chu-Xian Quan, Yuan-Yuan He, Md. F. Kulyar, Jia-Kui Li, Quan Mo · 2025 · Pesticide Biochemistry and Physiology
  96. The Potential Protective Effects of Intermittent Fasting Against Radiation-Induced Brain Damage in a Rat Model: Suggested Involvement of IRS-1/PI3 K/AKT and BDNF/TrkB Signaling Pathways
    Eman F. S. Taha, Hebatallah E. Mohamed, Lobna M. Anees, Hayam Mostafa, Eman Salah Eldin · 2025 · Molecular Neurobiology
  97. Effects of Apilarnil on Type 2 Diabetes-Induced IRS-1/PI3K/Akt Mediated Insulin Resistance in Male Rats
    Fatma Karagözoğlu, E. Şahin, Şule Melek, Saliha Bediz Şahin, R. Koca, H. Yüksel, A. Güngören · 2025 · ACS Omega
  98. Metabolites from the Dendrobium Endophyte Pseudomonas protegens CM-YJ44 Alleviate Insulin Resistance in HepG2 Cells via the IRS1/PI3K/Akt/GSK3β/GLUT4 Pathway
    Lu-Qi Qin, Yixia Zhou, Bei Fan, Jiahuan Zheng, Rao Diao, Jia-Meng Liu, Feng-Zhong Wang · 2025 · Pharmaceuticals
  99. Multi-Target Glitazones for Modulating Peroxisome Proliferator-Activated Receptor-γ, Cyclooxygenase-2, and Carbonic Anhydrases for the Management of Metabolic Dysfunction.
    Perihan A. Elzahhar, Hisham A. Nematalla, Malak A. Abouayana, E. S. E. El Ashry, Mahmoud Balbaa, A. Petreni, Rasha A. Nassra, Hend A. Yassin, Yasmine N. Kamel, Mohamed A. Elrewiny et al. · 2025 · ACS Pharmacology & Translational Science
  100. Is Deuterium Sequestering by Reactive Carbon Atoms an Important Mechanism to Reduce Deuterium Content in Biological Water?
    S. Seneff, G. Nigh, A. Kyriakopoulos · 2025 · FASEB bioAdvances