The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Surf the Post-translational Modification Network of p53 Regulation
Open accessAbstract
Among the human genome, p53 is one of the first tumor suppressor genes to be discovered. It has a wide range of functions covering cell cycle control, apoptosis, genome integrity maintenance, metabolism, fertility, cellular reprogramming and autophagy. Although different possible underlying mechanisms for p53 regulation have been proposed for decades, none of them is conclusive. While much literature focuses on the importance of individual post-translational modifications, further explorations indicate a new layer of p53 coordination through the interplay of the modifications, which builds up a complex 'network'. This review focuses on the necessity, characteristics and mechanisms of the crosstalk among post-translational modifications and its effects on the precise and selective behavior of p53.
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“Accumulated p53 is activated and stabilized by posttranslational modifications, including phosphorylation, acetylation and methylation.29–32”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [29]
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Dyson, H. J., & Wright, P. E. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1589 · Cited by 3,871
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Cited by
P53 in survival, death and metabolic health: a lifeguard with a licence to kill.
Kruiswijk, F., Labuschagne, C. F., & Vousden, K. H. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4007 · Cited by 1,080
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
Regulating tumor suppressor genes: post-translational modifications
Chen, L., Liu, S., & Tao, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0196-9 · Cited by 449
p53 modifications: exquisite decorations of the powerful guardian
Liu, Y., Tavana, O., & Gu, W. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz060 · Cited by 392
Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease
Dolgacheva, L. P., Berezhnov, A. V., Fedotova, E. I., Zinchenko, V. P., & Abramov, A. Y. (2019) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-019-09798-4 · Cited by 254
Metadata
- Authors
- Gu, B., & Zhu, W.-G.
- Venue
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2012
- Volume
- 8
- Issue
- 5
- Pages
- 672-684
- ISSN
- 1449-2288 (ISSN-L)
- OpenAlex
- W2104694670
- Cited by
- 235
- References
- 25
- FWCI
- 11.93
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gu, B., & Zhu, W.-G. (2012). Surf the Post-translational Modification Network of p53 Regulation. International Journal of Biological Sciences. https://doi.org/10.7150/ijbs.4283
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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