Cited by 1,106Cancer-related Molecular PathwaysCell death mechanisms and regulationAutophagy in Disease and Therapy

Cytoplasmic functions of the tumour suppressor p53

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Green, Douglas R., Kroemer, Guido·2009·Nature

Abstract

The principal tumour-suppressor protein, p53, accumulates in cells in response to DNA damage, oncogene activation and other stresses. It acts as a nuclear transcription factor that transactivates genes involved in apoptosis, cell cycle regulation and numerous other processes. An emerging area of research unravels additional activities of p53 in the cytoplasm, where it triggers apoptosis and inhibits autophagy. These previously unknown functions contribute to the mission of p53 as a tumour suppressor.

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  • p53 protein can physically translocate to the mitochondria where it promotes membrane permeabilization and the release of the mitochondrial pro-apoptotic factors.

    “In addition, p53 protein can physically translocate to the mitochondria where it promotes membrane permeabilization and the release of the mitochondrial pro-apoptotic factors(Green and Kroemer, 2009).”

    From Programmed cell death in aging (2015) · cites this paper as Green and Kroemer, 2009

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Authors
Green, D. R., & Kroemer, G.
Affiliations
  • St. Jude Children's Research Hospital (US)
  • Université Paris-Sud (FR)
Corresponding author
  • Green, Douglas R.
  • Kroemer, Guido
Venue
Nature
Published
2009-04
Volume
458
Issue
7242
Pages
1127-1130
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2059999514
Cited by
1,106
References
40
Citations by year
2026: 17 · 2025: 34 · 2024: 37 · 2023: 69 · 2022: 51 · 2021: 51 · 2020: 54 · 2019: 57 · 2018: 62 · 2017: 59 · 2016: 88 · 2015: 74 · 2014: 69 · 2013: 93 · 2012: 91
FWCI
8.46
Type
journal article
Language
en
Open access
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
  • Institut National Du Cancer
  • National Cancer Institute (P01CA069381)
  • National Institute of General Medical Sciences (R37GM052735)
  • National Institute of Allergy and Infectious Diseases (R01AI044828, R01AI040646, R01AI047891)
Topics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
p53, tumour suppressor, apoptosis, autophagy inhibition, DNA damage response, oncogene activation, transcription factors, cancer therapy targets
MeSH terms
Animals, Autophagy, Cell Nucleus, Cytoplasm, Humans, Mitochondria, Neoplasms, Transcription, Genetic, Tumor Suppressor Protein p53, Apoptosis

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