The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Interleukin-6, a Major Cytokine in the Central Nervous System
Open accessAbstract
Interleukin-6 (IL-6) is a cytokine originally identified almost 30 years ago as a B-cell differentiation factor, capable of inducing the maturation of B cells into antibody-producing cells. As with many other cytokines, it was soon realized that IL-6 was not a factor only involved in the immune response, but with many critical roles in major physiological systems including the nervous system. IL-6 is now known to participate in neurogenesis (influencing both neurons and glial cells), and in the response of mature neurons and glial cells in normal conditions and following a wide arrange of injury models. In many respects, IL-6 behaves in a neurotrophin-like fashion, and seemingly makes understandable why the cytokine family that it belongs to is known as neuropoietins. Its expression is affected in several of the main brain diseases, and animal models strongly suggest that IL-6 could have a role in the observed neuropathology and that therefore it is a clear target of strategic therapies.
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“IL-6 is a prototypical four-helix bundle cytokine that is the founder member of the neuropoietins, a group of cytokines structurally related, that include IL-6, IL-11, IL-27, IL-31, leukemia inhibitory factor, oncostatin M, cardiotrophin-1, neuropoietin and cytokine cardiotrophin-like (also known as new neurotrophin 1…”
BackgroundInflammatory Blockade Restores Adult Hippocampal Neurogenesis
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Inflammation is detrimental for neurogenesis in adult brain
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Interleukin-6-deficient mice develop mature-onset obesity
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Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939
Obesity and neuroinflammation: A pathway to cognitive impairment
Miller, A. A., & Spencer, S. J. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.04.001 · Cited by 788
The role of inflammation in the development of epilepsy
Rana, A., & Musto, A. E. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1192-7 · Cited by 709
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Metadata
- Authors
- Erta, M., Quintana, A., & Hidalgo, J.
- Venue
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2012
- Volume
- 8
- Issue
- 9
- Pages
- 1254-1266
- ISSN
- 1449-2288 (ISSN-L)
- OpenAlex
- W2139253645
- Cited by
- 1,087
- References
- 18
- FWCI
- 18.89
- Type
- journal article
- Language
- en
- Open access
- gold
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