The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer
Open accessAbstract
Aberrant activation of the PI3K/Akt pathway commonly occurs in cancers and correlates with multiple aspects of malignant progression. In particular, recent evidence suggests that the PI3K/Akt signaling plays a fundamental role in promoting the so-called aerobic glycolysis or Warburg effect, by phosphorylating different nutrient transporters and metabolic enzymes, such as GLUT1, HK2, PFKB3/4 and PKM2, and by regulating various molecular networks and proteins, including mTORC1, GSK3, FOXO transcription factors, MYC and HIF-1α. This leads to a profound reprogramming of cancer metabolism, also impacting on pentose phosphate pathway, mitochondrial oxidative phosphorylation, de novo lipid synthesis and redox homeostasis and thereby allowing the fulfillment of both the catabolic and anabolic demands of tumor cells. The present review discusses the interactions between the PI3K/Akt cascade and its metabolic targets, focusing on their possible therapeutic implications.
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3 retracted
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RetractedRETRACTED: SLC1A3 promotes gastric cancer progression via the PI3K/AKT signalling pathway
Xu, L., Chen, J., Jia, L., Chen, X., Moumin, F. A., & Cai, J. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16060 · Cited by 62
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RetractedUnderstanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
The Warburg Effect: How Does it Benefit Cancer Cells?
Liberti, M. V., & Locasale, J. W. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.12.001 · Cited by 5,150
Otto Warburg's contributions to current concepts of cancer metabolism
Koppenol, W. H., Bounds, P. L., & Dang, C. V. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3038 · Cited by 3,427
Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation
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Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
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ROS in cancer therapy: the bright side of the moon
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The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism
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Cited by
Altered metabolism in cancer: insights into energy pathways and therapeutic targets
Tufail, M., Jiang, C.-H., & Li, N. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02119-3 · Cited by 534
Metabolic reprogramming: The driving force behind cancer drug resistance
El-Sehrawy, A. A. M. A., Hsu, C.-Y., Alkhathami, A. G., Chandra, M., Basunduwah, T. S., Malathi, H., Senapati, J. N., Gautam, A., Kadhem, M., & Yasin, H. A. (2025) · Seminars in Oncology · doi:10.1016/j.seminoncol.2025.152392 · Cited by 11
Metadata
- Authors
- Fontana, F., Giannitti, G., Marchesi, S., & Limonta, P.
- Venue
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2024
- Volume
- 20
- Issue
- 8
- Pages
- 3113-3125
- ISSN
- 1449-2288 (ISSN-L)
- OpenAlex
- W4399127042
- Cited by
- 280
- References
- 170
- FWCI
- 42.84
- Type
- journal article
- Language
- en
- Open access
- gold
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- Fontana, F., Giannitti, G., Marchesi, S., & Limonta, P. (2024). The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer. International Journal of Biological Sciences. https://doi.org/10.7150/ijbs.89942
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
