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Cited by 14Liver physiology and pathologyLiver Disease Diagnosis and TreatmentCardiac Fibrosis and Remodeling

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Hepatic stellate cell-derived microfibrillar-associated protein 2 prevents liver fibrosis by regulating extracellular matrix and inflammation

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Zhang, Wen, Wu, Wenyue, Zhang, Ning, Li, Hong, Sun, Yameng, Ge, Xiaodong, Han, Hui, Chen, Shuyan, Xu, Anjian, Komakula, Sai Santosh Babu, Wang, Chao, Subramaniyam, Nithyananthan, Han, Qi, Yang, Aiting, Yan, Xuzhen, Nieto, Natalia, You, Hong, Chen, Wei·2025·Theranostics
DOI 10.7150/thno.109771PMC PMC11980660
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Abstract

: This study reveals the compensatory protective effects of HSC-derived MFAP-2 on liver fibrosis and its underlying mechanisms. Enhancing MFAP-2 in HSCs may therefore benefit patients with liver fibrosis.

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  • Accumulating evidence highlights ECM remodeling and tissue mechanics as active determinants of hepatocyte behavior.

    “accumulating evidence highlights extracellular matrix (ECM) remodeling and tissue mechanics as active determinants of hepatocyte behavior [12, 13, 14, 15, 16].”

    From Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction (2026) · cites this paper as [13]

    The Introduction (page unavailable) links ECM accumulation in liver fibrosis to increased stiffness and viscoelasticity. The Results (page unavailable) link ECM remodeling to focal-adhesion signaling in hepatic stellate cells. These passages support an active role for ECM remodeling and tissue mechanics in liver disease, but they do not establish them as determinants of hepatocyte behavior. (LLM, conf=0.86)

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Metadata

Authors
Zhang, W., Wu, W., Zhang, N., Li, H., Sun, Y., Ge, X., Han, H., Chen, S., Xu, A., Komakula, S. S. B., Wang, C., Subramaniyam, N., Han, Q., Yang, A., Yan, X., Nieto, N., You, H., & Chen, W.
Affiliations
  • Capital Medical University (CN)
  • University of Illinois Chicago (US)
Corresponding author
  • Nieto, Natalia
  • You, Hong
ORCID
Venue
Theranostics
Publisher
Ivyspring International Publisher
Published
2025-03-10
Volume
15
Issue
9
Pages
4033-4053
ISSN
1838-7640 (ISSN-L)
DOI
10.7150/thno.109771
PMC
PMC11980660
OpenAlex
W4408371095
Cited by
13
References
0
Citations by year
2026: 10 · 2025: 3
FWCI
7.31
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Theranostics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK134461)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
hepatic stellate cells, liver fibrosis, extracellular matrix, inflammation
MeSH terms
Animals, Carbon Tetrachloride, Disease Models, Animal, Extracellular Matrix, Humans, Inflammation, Liver, Liver Cirrhosis, Male, Mice, Inbred C57BL, Extracellular Matrix Proteins, Mice, Knockout, Mice, Hepatic Stellate Cells

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