Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Ma, Juan; Xie, Ning; Wang, Ziwei; Liang, Xiru; Han, Yulong; Zhao, Qiang; Wang, Ming; Lu, Hongwei; Kou, Wanyi; Alazawi, William; Wang, Jinhai; Li, Lu; Liu, Ning; Liu, Na; Shi, Haitao; Xu, Feng

doi:10.1002/advs.202519109

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Metabolic dysfunction–associated steatotic liver disease (MASLD) is shaped by metabolic injury and tissue mechanics. This study investigated whether liver stiffening occurs early in MASLD and how extracellular matrix (ECM) mechanics interact with lipid droplet (LD) overload to promote inflammatio…