The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Polydopamine Nanoparticles as a Versatile Molecular Loading Platform to Enable Imaging-guided Cancer Combination Therapy
Open accessAbstract
Cancer combination therapy to treat tumors with different therapeutic approaches can efficiently improve treatment efficacy and reduce side effects. Herein, we develop a theranostic nano-platform based on polydopamine (PDA) nanoparticles, which then are exploited as a versatile carrier to allow simultaneous loading of indocyanine green (ICG), doxorubicin (DOX) and manganese ions (PDA-ICG-PEG/DOX(Mn)), to enable imaging-guided chemo & photothermal cancer therapy. In this system, ICG acts as a photothermal agent, which shows red-shifted near-infrared (NIR) absorbance and enhanced photostability compared with free ICG. DOX, a model chemotherapy drug, is then loaded onto the surface of PDA-ICG-PEG with high efficiency. With Mn(2+) ions intrinsically chelated, PDA-ICG-PEG/DOX(Mn) is able to offer contrast under T1-weighted magnetic resonance (MR) imaging. In a mouse tumor model, the MR imaging-guided combined chemo- & photothermal therapy achieves a remarkable synergistic therapeutic effect compared with the respective single treatment modality. This work demonstrates that PDA nanoparticles could serve as a versatile molecular loading platform for MR imaging guided combined chemo- & photothermal therapy with minimal side effects, showing great potential for cancer theranostics.
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Liu, Y., Ai, K., & Lu, L. (2014) · Chemical Reviews · doi:10.1021/cr400407a · Cited by 4,794
Cited by
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Bao, X., Zhao, J., Sun, J., Hu, M., & Yang, X. (2018) · ACS Nano · doi:10.1021/acsnano.8b04022 · Cited by 722
Carbon-based nanomaterials as an emerging platform for theranostics
Patel, K. D., Singh, R. K., & Kim, H.-W. (2019) · Materials Horizons · doi:10.1039/c8mh00966j · Cited by 555
Dong, Z., Feng, L., Hao, Y., Chen, M., Gao, M., Chao, Y., Zhao, H., Zhu, W., Liu, J., Liang, C., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11036 · Cited by 490
Self-citationMetal‐Containing Polydopamine Nanomaterials: Catalysis, Energy, and Theranostics
Wang, Z., Zou, Y., Li, Y., & Cheng, Y. (2020) · Small · doi:10.1002/smll.201907042 · Cited by 459
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Metadata
- Authors
- Dong, Z., Gong, H., Gao, M., Zhu, W., Sun, X., Feng, L., Fu, T., Li, Y., & Liu, Z.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2016
- Volume
- 6
- Issue
- 7
- Pages
- 1031-1042
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W2402643300
- Cited by
- 296
- References
- 1
- FWCI
- 15.96
- Type
- journal article
- Language
- en
- Open access
- gold
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