The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Nucleolin-targeted Extracellular Vesicles as a Versatile Platform for Biologics Delivery to Breast Cancer
Open accessAbstract
Small interfering RNAs (siRNA)/microRNAs (miRNA) have promising therapeutic potential, yet their clinical application has been hampered by the lack of appropriate delivery systems.Herein, we employed extracellular vesicles (EVs) as a targeted delivery system for small RNAs.EVs are cell-derived small vesicles that participate in cell-to-cell communication for protein and RNA delivery.We used the aptamer AS1411-modified EVs for targeted delivery of siRNA/microRNA to breast cancer tissues.Tumor targeting was facilitated via AS1411 binding to nucleolin, which is highly expressed on the surface membrane of breast cancer cells.This delivery vesicle targeted let-7 miRNA delivery to MDA-MB-231 cells in vitro as confirmed with fluorescent microscopic imaging and flow cytometry.Also, intravenously delivered AS1411-EVs loaded with miRNA let-7 labeled with the fluorescent marker, Cy5, selectively targeted tumor tissues in tumor-bearing mice and inhibited tumor growth.Importantly, the modified EVs were well tolerated and showed no evidence of nonspecific side effects or immune response.Thus, the RNAi nanoplatform is versatile and can deliver siRNA or miRNA to breast cancer cells both in vitro and in vivo.Our results suggest that the AS1411-EVs have a great potential as drug delivery vehicles to treat cancers.
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Cites
Tumour exosome integrins determine organotropic metastasis
Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
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Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells
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Exosomes are natural carriers of exogenous siRNA to human cells in vitro
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MicroRNA‐21 protects neurons from ischemic death
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“To minimize the experimental background, we chose Cel-miRNA-67 (Caenorhabditis elegans-derived miRNA not expressed in mammals) [43] for analyzing the efflux of miRNA from the AS1411-EVs as opposed to human or mouse let 7.”
MethodSelf-citationCheng, Q., Du, L., Meng, L., Han, S., Wei, T., Wang, X., Wu, Y., Song, X., Zhou, J., Zheng, S., et al. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b11789 · Cited by 85
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Cited by
Engineering exosomes for targeted drug delivery
Liang, Y., Duan, L., Lu, J., & Xia, J. (2021) · Theranostics · doi:10.7150/thno.52570 · Cited by 1,547
Biodistribution of extracellular vesicles following administration into animals: A systematic review
Kang, M., Jordan, V., Blenkiron, C., & Chamley, L. W. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12085 · Cited by 485
Extracellular vesicle-based drug delivery systems for cancer treatment
Walker, S., Busatto, S., Pham, A., Tian, M., Suh, A., Carson, K., Quintero, A., Lafrence, M., Malik, H., Santana, M. X., et al. (2019) · Theranostics · doi:10.7150/thno.37097 · Cited by 429
Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications
Mondal, J., Pillarisetti, S., Junnuthula, V., Saha, M., Hwang, S. R., Park, I.-K., & Lee, Y.-K. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.12.027 · Cited by 416
Non-viral vectors for RNA delivery
Yan, Y., Liu, X.-Y., Lu, A., Wang, X.-Y., Jiang, L.-X., & Wang, J.-C. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.01.008 · Cited by 332
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Metadata
- Authors
- Wang, Y., Chen, X., Tian, B., Liu, J., Yang, L., Zeng, L., Chen, T., Hong, A., & Wang, X.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2017
- Volume
- 7
- Issue
- 5
- Pages
- 1360-1372
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W2604373833
- Cited by
- 196
- References
- 7
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- gold
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