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A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

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Biogenesis and secretion of exosomes

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Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

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Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

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Tetraspanins in Extracellular Vesicle Formation and Function

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Exosomal-like vesicles are present in human blood plasma

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Exosome Theranostics: Biology and Translational Medicine

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Exosomes with Immune Modulatory Features Are Present in Human Breast Milk

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Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

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Using exosomes, naturally-equipped nanocarriers, for drug delivery

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ExoCarta 2012: database of exosomal proteins, RNA and lipids

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Exfoliation of membrane ecto-enzymes in the form of micro-vesicles

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Exosomes: Therapy delivery tools and biomarkers of diseases

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The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

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Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

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Molecular lipidomics of exosomes released by PC-3 prostate cancer cells

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NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

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Body fluid derived exosomes as a novel template for clinical diagnostics

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Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

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CD68/macrosialin: not just a histochemical marker

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Exosome uptake through clathrin-mediated endocytosis and macropinocytosis and mediating miR-21 delivery

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Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

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Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: In vitro and in vivo evaluations

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Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

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Exosome–Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs

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Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

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Exosome-mediated delivery of siRNA in vitro and in vivo

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Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

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Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

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Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature

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Surface Functionalization of Exosomes Using Click Chemistry

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Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance

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Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

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Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems

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Display of GPI‐anchored anti‐EGFR nanobodies on extracellular vesicles promotes tumour cell targeting

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Macrophage-derived exosome-mimetic hybrid vesicles for tumor targeted drug delivery

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Engineered Exosomes With Ischemic Myocardium‐Targeting Peptide for Targeted Therapy in Myocardial Infarction

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Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy

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Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

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Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration

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Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy

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Self-assembly of extracellular vesicle-like metal–organic framework nanoparticles for protection and intracellular delivery of biofunctional proteins

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Stabilization of Exosome-targeting Peptides via Engineered Glycosylation

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Exosome-SIRPα, a CD47 blockade increases cancer cell phagocytosis

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A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells

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RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer’s disease

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Engineered exosome-mediated delivery of functionally active miR-26a and its enhanced suppression effect in HepG2 cells

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Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity

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Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice

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Bioinspired exosome-like therapeutics and delivery nanoplatforms

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Engineered Exosome-Mediated Near-Infrared-II Region V2C Quantum Dot Delivery for Nucleus-Target Low-Temperature Photothermal Therapy

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Dendritic Cells Release HLA-B-Associated Transcript-3 Positive Exosomes to Regulate Natural Killer Function

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Proteomic Analysis of Two Types of Exosomes in Human Whole Saliva

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Aptamer-Conjugated Extracellular Nanovesicles for Targeted Drug Delivery

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Extracellular vesicles as a platform for membrane‐associated therapeutic protein delivery

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Exosomes Engineered to Express a Cardiomyocyte Binding Peptide Demonstrate Improved Cardiac Retention in Vivo

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Engineered Exosomes for Targeted Transfer of siRNA to HER2 Positive Breast Cancer Cells

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Exosome target cell selection and the importance of exosomal tetraspanins: a hypothesis

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Aptamer-Functionalized Exosomes: Elucidating the Cellular Uptake Mechanism and the Potential for Cancer-Targeted Chemotherapy

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Cell‐surface engineering with GPI‐anchored proteins

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Exosomes as Reconfigurable Therapeutic Systems

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Molecular Recognition-Based DNA Nanoassemblies on the Surfaces of Nanosized Exosomes

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Methotrexate-Loaded Extracellular Vesicles Functionalized with Therapeutic and Targeted Peptides for the Treatment of Glioblastoma Multiforme

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Nucleolin-targeted Extracellular Vesicles as a Versatile Platform for Biologics Delivery to Breast Cancer

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Exosome Display technology: Applications to the development of new diagnostics and therapeutics

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Revisiting the road to the discovery of exosomes

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Chimeric peptide engineered exosomes for dual-stage light guided plasma membrane and nucleus targeted photodynamic therapy

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Rapid Detection of Exosomal MicroRNAs Using Virus‐Mimicking Fusogenic Vesicles

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The use of RGD-engineered exosomes for enhanced targeting ability and synergistic therapy toward angiogenesis

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Exosome Targeting of Tumor Antigens Expressed by Cancer Vaccines Can Improve Antigen Immunogenicity and Therapeutic Efficacy

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Virus‐Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes

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The immunogenicity of dendritic cell-derived exosomes

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Engineered targeting tLyp-1 exosomes as gene therapy vectors for efficient delivery of siRNA into lung cancer cells

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Harnessing Exosomes for the Development of Brain Drug Delivery Systems

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Physiological and pathological impact of exosomes of adipose tissue

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Mesenchymal stem cell-derived exosomes as a new therapeutic strategy in the brain tumors

Ghasempour, E., Hesami, S., Movahed, E., Keshel, S. H., & Doroudian, M. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03212-4 · Cited by 95 · see citing works

Viral vectors and extracellular vesicles: innate delivery systems utilized in CRISPR/Cas-mediated cancer therapy

Ahmadi, S. E., Soleymani, M., Shahriyary, F., Amirzargar, M. R., Mahya, O., Fattahi, D., & Safa, M. (2023) · Cancer Gene Therapy · doi:10.1038/s41417-023-00597-z · Cited by 95 · see citing works

Sphingosine-1-phosphate derived from PRP-Exos promotes angiogenesis in diabetic wound healing via the S1PR1/AKT/FN1 signalling pathway

Chen, T., Song, P., He, M. Y., Rui, S., Duan, X., Ma, Y., Armstrong, D. G., & Deng, W. (2023) · Burns & Trauma · doi:10.1093/burnst/tkad003 · Cited by 95 · see citing works

Ginger: a representative material of herb-derived exosome-like nanoparticles

Zhu, H., & He, W. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1223349 · Cited by 95 · see citing works

Engineered mammalian and bacterial extracellular vesicles as promising nanocarriers for targeted therapy

Liu, H., Geng, Z., & Su, J. (2022) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2022.04 · Cited by 94 · see citing works

Upscaling human mesenchymal stromal cell production in a novel vertical-wheel bioreactor enhances extracellular vesicle secretion and cargo profile

Jeske, R., Liu, C., Duke, L. C., Castro, M. L. C., Muok, L., Arthur, P., Singh, M. S., Jung, S., Sun, L. J., & Li, Y. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.07.004 · Cited by 94 · see citing works

Cell‐specific targeting of extracellular vesicles through engineering the glycocalyx

Zheng, W., He, R., Liang, X., Roudi, S., Bost, J., Coly, P., van Niel, G., & Andaloussi, S. E. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12290 · Cited by 91 · see citing works

Fruit‐Derived Extracellular‐Vesicle‐Engineered Structural Droplet Drugs for Enhanced Glioblastoma Chemotherapy

Chen, J., Pan, J., Liu, S., Zhang, Y., Sha, S., Guo, H., Wang, X., Hao, X., Zhou, H., Tao, S., et al. (2023) · Advanced Materials · doi:10.1002/adma.202304187 · Cited by 90 · see citing works

Engineered Exosomes for Tumor-Targeted Drug Delivery: A Focus on Genetic and Chemical Functionalization

Akbari, A., Nazari‐Khanamiri, F., Ahmadi, M., Shoaran, M., & Rezaie, J. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010066 · Cited by 89 · see citing works

Surface functionalization of exosomes for chondrocyte-targeted siRNA delivery and cartilage regeneration.

Zhang, H., Yan, W.-J., Wang, J., Xie, S.-Q., Tao, W., Lee, C.-W., Zhang, X., Zhang, G.-Y., Liu, Y.-F., Wei, D., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.04.009 · Cited by 88 · see citing works

Bone‐Targeted Exosomes: Strategies and Applications

Wang, J., Li, X., Wang, S., Cui, J., Ren, X., & Su, J. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202203361 · Cited by 88 · see citing works

Harnessing knee joint resident mesenchymal stem cells in cartilage tissue engineering

Xu, X. G., Xu, L., Xia, J., Wen, C., Liang, Y., & Zhang, Y. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.07.024 · Cited by 92 · see citing works

Targeted Drug Delivery Systems for Curcumin in Breast Cancer Therapy

Huang, M., Zhai, B., Fan, Y. B., Sun, J., Shi, Y., Zhang, X., Zou, J., Wang, J., & Guo, D. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s410688 · Cited by 86 · see citing works

Engineered exosomes and composite biomaterials for tissue regeneration

Hu, W., Wang, W., Chen, Z., Chen, Y., & Wang, Z. (2024) · Theranostics · doi:10.7150/thno.93088 · Cited by 85 · see citing works

Exosome-based drug delivery systems and their therapeutic applications

Lee, J., Lee, J.-H., Chakraborty, K., Hwang, J., & Lee, Y.-K. (2022) · RSC Advances · doi:10.1039/d2ra02351b · Cited by 85 · see citing works

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles

Zheng, W., Rädler, J., Sork, H., Niu, Z., Roudi, S., Bost, J., Görgens, A., Zhao, Y. H., Mamand, D. R., Liang, X., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40453-0 · Cited by 85 · see citing works

Penetration of Microplastics and Nanoparticles Through Skin: Effects of Size, Shape, and Surface Chemistry

Menichetti, A., Mordini, D., & Montalti, M. (2024) · Journal of Xenobiotics · doi:10.3390/jox15010006 · Cited by 83 · see citing works

Precise nanoscale fabrication technologies, the “last mile” of medicinal development

Bi, Y., Xie, S., Li, Z., Dong, S., & Teng, L. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.03.040 · Cited by 83 · see citing works

Engineering exosomes and exosome-like nanovesicles for improving tissue targeting and retention

Li, L., Wang, F., Zhu, D., Hu, S., Cheng, K., & Li, Z. (2024) · Fundamental Research · doi:10.1016/j.fmre.2024.03.025 · Cited by 85 · see citing works

Exosomes as Targeted Delivery Platform of CRISPR/Cas9 for Therapeutic Genome Editing

Duan, L., Ouyang, K., Wang, J., Xu, L., Xu, X., Wen, C., Xie, Y., Liang, Y., & Xia, J. (2021) · ChemBioChem · doi:10.1002/cbic.202100359 · Cited by 82 · see citing works

Tri-Layer Core–Shell Fibers from Coaxial Electrospinning for a Modified Release of Metronidazole

Wang, Y., Liu, L., Zhu, Y., Wang, L., Yu, D., & Liu, L. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15112561 · Cited by 82 · see citing works

Exosomes derived from adipose-derived stem cells overexpressing glyoxalase-1 protect endothelial cells and enhance angiogenesis in type 2 diabetic mice with limb ischemia

Zhang, X. Y., Jiang, Y., Huang, Q., Wu, Z., Pu, H., Xu, Z., Li, B., Lu, X., Yang, X., Qin, J., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02475-7 · Cited by 80 · see citing works

Diagnostic and Therapeutic Potential of Extracellular Vesicles

Kodam, S. P., & Ullah, M. (2021) · Technology in Cancer Research & Treatment · doi:10.1177/15330338211041203 · Cited by 82 · see citing works

Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives

Ahmed, W., Mushtaq, A., Ali, S., Khan, N., Liang, Y., & Duan, L. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00856 · Cited by 54 · see citing works

Bioengineering and modification of exosome nanovesicles for targeted drug delivery

Desai, N., Salave, S., & Vora, L. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-29052-7.00008-8 · Cited by 1 · see citing works

Exosomes: Cell-Derived Nanoplatforms for the Delivery of Cancer Therapeutics

Kim, H., Kim, E. H., Kwak, G., Chi, S.-G., Kim, S. H., & Yang, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010014 · Cited by 147 · see citing works

Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review

Chen, Z., Xiong, M., Tian, J., Song, D., Duan, S., & Zhang, L. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02259-6 · Cited by 160 · see citing works

Biology and Therapeutic Potential of Exosomes, Targeted Drug Delivery

Mateos-Ramírez, F. A. G., Hernández‐Ortega, L. D., Gurrola‐Díaz, C. M., Gasca-Lozano, L. E., Sánchez-Orozco, L. V., & Salazar-Montes, A. M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27188145