Cited by 224Alzheimer's disease research and treatmentsBarrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Open access
Hultqvist, Greta, Syvänen, Stina, Fang, Xiaotian T, Lannfelt, Lars, Sehlin, Dag·2017·Theranostics

Abstract

specificity. Thus, our innovative recombinant design markedly increases mAb158 brain uptake, which makes it a strong candidate for improved Aβ immunotherapy and as a PET radioligand for early diagnosis and evaluation of treatment effect in AD. Moreover, this approach could be applied to any target within the brain.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.7150/thno.17155

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A recombinant blood brain barrier shuttle uses antibody-mAb158 that binds to Aβ fibrils.

    “A recombinant design has been used to develop a blood brain barrier shuttle which uses an antibody-mAb158 that binds to Aβ fibrils.”
  • The fusion shuttle selectively permeates the BBB and delivers mAb158 in the brain, working as Aβ immunotherapy and as a radio-ligand for PET diagnosis.

    “Due to this fusion, the shuttle selectively permeates the BBB and delivers mAb158 in the brain which works as Aβ immunotherapy and also as a radio-ligand for PET diagnosis, aiding in the evaluation of the therapy simultaneously [108].”
  • The antibody is fused with two single chain variable fragments of transferrin receptor antibody-8D3, which enhances uptake in the brain.

    “This antibody is fused with two single chain variable fragments of the transferrin receptor antibody-8D3. 8D3 is known to enhance uptake in the brain.”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Hultqvist, G., Syvänen, S., Fang, X. T., Lannfelt, L., & Sehlin, D.
Affiliations
Uppsala University (SE)
Corresponding author
Hultqvist, Greta
Venue
Theranostics
Published
2017
Volume
7
Issue
2
Pages
308-318
ISSN
1838-7640 (ISSN-L)
OpenAlex
W2565411144
Cited by
224
References
30
Citations by year
2026: 18 · 2025: 38 · 2024: 27 · 2023: 35 · 2022: 35 · 2021: 25 · 2020: 15 · 2019: 12 · 2018: 15 · 2017: 4
FWCI
8.31
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Theranostics (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
Funders
  • Gun och Bertil Stohnes Stiftelse
  • Stiftelsen för Gamla Tjänarinnor
  • Vetenskapsrådet (#2012-1593, #2012-2172)
  • Åhlén-stiftelsen
  • Alzheimerfonden
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
transferrin receptor, antibody absorption, amyloid-beta immunotherapy, Alzheimer's disease, PET radiotracer, brain targeting
MeSH terms
Alzheimer Disease, Animals, Antibodies, Blood-Brain Barrier, Brain Chemistry, Disease Models, Animal, Immunotherapy, Mice, Transgenic, Receptors, Transferrin, Recombinant Proteins, Neuroprotective Agents, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review