Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics

Feng, Xiaojun, Sureda, Antoni, Jafari, Samineh, Memariani, Zahra, Tewari, Devesh, Annunziata, Giuseppe, Barrea, Luigi, Hassan, Sherif T.S. +10 more·2019·Theranostics

DOI 10.7150/thno.30787

Cites (400)

Items 201–400 of 400

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Berberine confers neuroprotection in coping with focal cerebral ischemia by targeting inflammatory cytokines
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Berberine alleviates oxidized low‐density lipoprotein‐induced macrophage activation by downregulating galectin‐3 via the NF‐κB and AMPK signaling pathways
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Berberine treatment prevents cardiac dysfunction and remodeling through activation of 5′-adenosine monophosphate-activated protein kinase in type 2 diabetic rats and in palmitate-induced hypertrophic H9c2 cells
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Restoration of GLP-1 secretion by Berberine is associated with protection of colon enterocytes from mitochondrial overheating in diet-induced obese mice
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Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo
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Berberine Ameliorates High Glucose-Induced Cardiomyocyte Injury via AMPK Signaling Activation to Stimulate Mitochondrial Biogenesis and Restore Autophagic Flux
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PI3K p55γ promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia–reperfusion
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Berberine modulates insulin signaling transduction in insulin-resistant cells
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Berberine activates AMPK to suppress proteolytic processing, nuclear translocation and target DNA binding of SREBP-1c in 3T3-L1 adipocytes
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Protective effects of berberine against doxorubicin-induced cardiotoxicity in rats by inhibiting metabolism of doxorubicin
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Combination of Berberine with Resveratrol Improves the Lipid-Lowering Efficacy
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Berberine regulates proliferation, collagen synthesis and cytokine secretion of cardiac fibroblasts via AMPK-mTOR-p70S6K signaling pathway.
Fen Ai, Manhua Chen, Bo Yu · 2015 · PubMed
Novel role of the nutraceutical bioactive compound berberine in lectin-like OxLDL receptor 1-mediated endothelial dysfunction in comparison to lovastatin
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Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells
D. Kukidome · 2006 · Diabetes
Synthesis and in vitro evaluation of 12-(substituted aminomethyl) berberrubine derivatives as anti-diabetics
Renjun Li, Jianbo Wu, Yun He · 2014 · Bioorganic & Medicinal Chemistry Letters
Berberine inhibits Chlamydia pneumoniae infection-induced vascular smooth muscle cell migration through downregulating MMP3 and MMP9 via PI3K
Lu Ma, Lijun Zhang, Beibei Wang, Junyan Wei, Jingya Liu, Lijun Zhang · 2015 · European Journal of Pharmacology
Molecular characterization of carnitine palmitoyltransferase IA in Megalobrama amblycephala and effects on its expression of feeding status and dietary lipid and berberine
Kangle Lu, Dingdong Zhang, Lina Wang, Weina Xu, Wenbin Liu · 2015 · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology
PPARα activation inhibits endothelin-1-induced cardiomyocyte hypertrophy by prevention of NFATc4 binding to GATA-4
Kang Le, Ruifang Li, Suowen Xu et al. · 2011 · Archives of Biochemistry and Biophysics
Berberine combined with atorvastatin downregulates LOX-1 expression through the ET-1 receptor in monocyte/macrophages
Liyi Chi, Lijing Peng, Xiaojing Hu, NA PAN, Yanhai Zhang · 2014 · International Journal of Molecular Medicine
CPU 86017, p-chlorobenzyltetrahydroberberine chloride, attenuates monocrotaline-induced pulmonary hypertension by suppressing endothelin pathway1
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[Inhibitory action of berberine on glucose absorption].
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Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis
Haidong Sun, Qian Liu, Hai Hu, Yisheng Jiang, Wentao Shao, Qihan Wang, Zhaoyan Jiang, Aihua Gu · 2018 · Cell Death and Disease
Head-to-Head Comparison of Anti-Inflammatory Performance of Known Natural Products In Vitro
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NUtraceutical TReatment for hYpercholesterolemia in HIV-infected patients: The NU-TRY(HIV) randomized cross-over trial
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Prostaglandins in Action
Siu Ling Wong, Wing Tak Wong, Xiao Yu Tian · 2010 · Advances in pharmacology
CPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activity
Min-You Qi, Feng Yu, De‐Zai Dai, Na Li, Yu-si Cheng, Yin Dai · 2010 · Acta Pharmacologica Sinica
Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: Selective inhibitors of dopamine D1 receptor
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Suppressive effects of berberine on atherosclerosis via downregulating visfatin expression and attenuating visfatin-induced endothelial dysfunction
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Effects of Berberine on NLRP3 and IL-1βExpressions in Monocytic THP-1 Cells with Monosodium Urate Crystals-Induced Inflammation
Yafei Liu, Cai-Yu-Zhu Wen, Zhe Chen, Yu Wang, Ying Huang, Shenghao Tu · 2016 · BioMed Research International
Berberine inhibits the ischemia‑reperfusion injury induced inflammatory response and apoptosis of myocardial cells through the phosphoinositide 3‑kinase/RAC‑α serine/threonine‑protein kinase and nuclear factor-κB signaling pathways
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Inhibitory effects of Zoagumhwan water extract and berberine on angiotensin II-induced monocyte chemoattractant protein (MCP)-1 expression and monocyte adhesion to endothelial cells
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Berberine Attenuates Vascular Remodeling and Inflammation in a Rat Model of Metabolic Syndrome
Xiaoxing Li, Chuanbao Li, Jie Xiao, Haiqing Gao, He‐Wen Wang, Xinyu Zhang, Cheng Zhang, Xiaoping Ji · 2015 · Biological and Pharmaceutical Bulletin
Berberine attenuates pulmonary arterial hypertension via protein phosphatase 2A signaling pathway both in vivo and in vitro
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Increased Bioavailable Berberine Protects Against Myocardial Ischemia Reperfusion Injury Through Attenuation of NFκB and JNK Signaling Pathways
Yang Yu, Ming Zhang, Yali Hu, Yali Zhao, Fei Teng, Xiaoyan Lv, Ji Li, Ying Zhang, Grant Michael Hatch, Li Chen · 2018 · International Heart Journal
Treatment update: thiazolidinediones in combination with metformin for the treatment of type 2 diabetes
Udho Thadani · 2007 · Vascular Health and Risk Management
Effects of berberine of L- and T-type calcium channels in guinea pig ventricular myocytes.
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Berberine modulates ASK1 signaling mediated through TLR4/TRAF2 via upregulation of miR-23a
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Berberine-attenuated monocyte adhesion to endothelial cells induced by oxidized low-density lipoprotein via inhibition of adhesion molecule expression
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Mechanism of the Aortic Relaxation Induced by Low Concentrations of Berberine
Kai Wong · 1998 · Planta Medica
Berberine induces hERG channel deficiency through trafficking inhibition
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Nutraceutical combination (red yeast rice, berberine and policosanols) improves aortic stiffness in low-moderate risk hypercholesterolemic patients
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Prevalence of cardiovascular medication on secondary prevention after myocardial infarction in China between 1995-2015: A systematic review and meta-analysis
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Effects of berberine on serum inflammatory factors and carotid atherosclerotic plaques in patients with acute cerebral ischemic stroke
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Berberine suppresses in vitro migration of human aortic smooth muscle cells through the inhibitions of MMP-2/9, u-PA, AP-1, and NF-κB
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Effect of berberine on acetylcholine-induced atrial fibrillation in rabbit.
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Effect of berberine on PPAR α -NO signalling pathway in vascular smooth muscle cell proliferation induced by angiotensin IV
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Berberine Attenuates NLRP3 Inflammasome Activation in Macrophages to Reduce the Secretion of Interleukin-1β.
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Inhibition of high glucose-induced apoptosis by uncoupling protein 2 in human umbilical vein endothelial cells
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Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency
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Effects of berberine on serum levels of inflammatory factors and inflammatory signaling pathway in obese mice induced by high fat diet
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Evaluation of the alpha-adrenoceptor antagonistic action of berberine in isolated organs.
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Beneficial effects of berberine on hemodynamics during acute ischemic left ventricular failure in dogs.
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Berberine inhibits tumor necrosis factor-α-induced expression of inflammatory molecules and activation of nuclear factor-κB via the activation of AMPK in vascular endothelial cells
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Thalibealine, a Novel Tetrahydroprotoberberine−Aporphine Dimeric Alkaloid from Thalictrum wangii
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Endothelial Microparticles (EMP) for the Assessment of Endothelial Function: An In Vitro and In Vivo Study on Possible Interference of Plasma Lipids
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An Effective Solution to Discover Synergistic Drugs for Anti-Cerebral Ischemia from Traditional Chinese Medicinal Formulae
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Berberine attenuates spontaneous action potentials in sinoatrial node cells and the currents of human HCN4 channels expressed in Xenopus laevis oocytes
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A safer hypoglycemic agent for type 2 diabetes—Berberine organic acid salt
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Berberine reduces the hypoxic-ischemic insult in rat pup brain
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Inhibition of CCL19 benefits non‑alcoholic fatty liver disease by inhibiting TLR4/NF‑κB‑p65 signaling
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Effect of Berberine on Angiogenesis and HIF-1α / VEGF Signal Transduction Pathway in Rats with Cerebral Ischemia - Reperfusion Injury.
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Microbiota transplantation reveals beneficial impact of berberine on hepatotoxicity by improving gut homeostasis
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Protective effect of berberine against cardiac ischemia/reperfusion injury by inhibiting apoptosis through the activation of Smad7
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Impacts of berberine on oxidized LDL-induced proliferation of human umbilical vein endothelial cells.
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Antidiabetic potential of polyherbal formulation DB14201: Preclinical development, safety and efficacy studies
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Combined analytical approaches to define biodistribution and biological activity of semi-synthetic berberrubine, the active metabolite of natural berberine
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Bidirectional regulation of adenosine 5′‐monophosphate–activated protein kinase activity by berberine and metformin in response to changes in ambient glucose concentration
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Berberine cooperates with adrenal androgen dehydroepiandrosterone sulfate to attenuate PDGF-induced proliferation of vascular smooth muscle cell A7r5 through Skp2 signaling pathway
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Nandinine, a Derivative of Berberine, Inhibits Inflammation and Reduces Insulin Resistance in Adipocytes via Regulation of AMP-Kinase Activity
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In Vivo Interrelationship between Insulin Resistance and Interferon Gamma Production: Protective and Therapeutic Effect of Berberine
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Berberine protects vascular endothelial cells in hypertensive rats.
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Design, synthesis and biological evaluation of a hybrid compound of berberine and magnolol for improvement of glucose and lipid metabolism
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Cardioprotection Is Alive But Remains Enigmatic
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Enhancement of Berberine Hypoglycemic Activity by Oligomeric Proanthocyanidins
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Perioperative beta-blockers for preventing surgery related mortality and morbidity
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NACHT, LRR and PYD domains-containing protein 3 inflammasome is activated and inhibited by berberine via toll-like receptor 4/myeloid differentiation primary response gene 88/nuclear factor-κB pathway, in phorbol 12-myristate 13-acetate-induced macrophages
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Raisanberine protected pulmonary arterial rings and cardiac myocytes of rats against hypoxia injury by suppressing NADPH oxidase and calcium influx
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(±)-Govadine and (±)-THP, Two Tetrahydroprotoberberine Alkaloids, as Selective α1-Adrenoceptor Antagonists in Vascular Smooth Muscle Cells
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Effect of berberine, liensinine and neferine on HERG channel expression
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Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice
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Effects of berberine on the expressions of NRF2 and HO-1 in endothelial cells of diabetic rat
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The anti-platelet-rich-plasma-clot-retraction effect of berberine and its mechanism
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Inhibition of endothelial microparticles-mediated oxidative stress by berberine and its relation with endothelial function in humans
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The assisting effect of berberine on urokinase and streptokinase induced thrombolysis
Chu Zhong · 1998 · Zhongguo yaolixue tongbao
Study on effect of berberine on modulating lipid and CPTⅠA gene expression
Hong Wang · 2011 · China Journal of Chinese Materia Medica
Antiplatelet effects and mechanisms of berberine
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The antihypertensive effect of the berberine derivative 6-protoberberine in spontaneously hypertensive rats
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The effects of berberine chloride on platelet activation of mice with dextransulphate sodium-induced colitis
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