Block of hERG Channels by Berberine: Mechanisms of Voltage- and State-Dependence Probed With Site-Directed Mutant Channels

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Mutations of the S4‐S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes

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Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes

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Probing the Interaction Between Inactivation Gating and d d-Sotalol Block ofHERG

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High affinity HERG K+ channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656

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Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency

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Structural and functional studies of the interaction between berberine and the hERG potassium channel provide evidence to its clinical use and drug development

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BindingDB Entry 50001409: Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes.

BindingDB (2020) · UC San Diego · doi:10.7270/q280554v

Untitled work

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Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency

Li, B., Yan, M., Zhang, K., Feng, L., Shi, Y., & Lv, L. L. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s91561 · Cited by 24 · see citing works

Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells

Yu, D., Lv, L. L., Li, F., Zhang, B., Wang, J., Zhan, G., Zhao, L., Zhao, X. Y., & Li, B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181823 · Cited by 13 · see citing works

Increase in action potential duration and inhibition of the delayed rectifier outward currentIKby berberine in cat ventricular myocytes

Sánchez‐Chapula, J. A. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15302.x · Cited by 42 · see citing works

Effect of berberine, liensinine and neferine on HERG channel expression

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