Molecular Imaging of Immune Cell Dynamics During De- and Remyelination in the Cuprizone Model of Multiple Sclerosis by [18F]DPA-714 PET and MRI
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Exosome treatment increases mean [18F]DPA-714 uptake in the hippocampus, indicating increased neuroinflammatory signals.
“We also observed increased mean [18F]DPA-714 uptake in the hippocampus (Fig. 1l), indicating an increased expression of neuroinflammatory signals in our experimental setting [32].”
From Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression (2022) · cites this paper as [32]
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“In accordance, histopathological studies have indicated that microglia outnumber astrocytes in active lesions and represent the prominent source of TSPO in MS [31, 34, 65, 68, 69].”
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“Second generation TSPO ligands may even allow to visualize the heterogeneity of inflammatory lesions in MS as well as give additional information to conventional MRI [7, 58].”
BackgroundGuglielmetti, C., Le Blon, D., Santermans, E., Salas-Perdomo, A., Daans, J., De Vocht, N., Shah, D., Hoornaert, C., Praet, J., Peerlings, J., et al. (2016) · Glia · doi:10.1002/glia.23053 · Cited by 76 · see citing works
Self-citationImpact of Endothelial 18-kDa Translocator Protein on the Quantification of<sup>18</sup>F-DPA-714
Wimberley, C., Lavisse, S., Brulon, V., Peyronneau, M.-A., Leroy, C., Bodini, B., Remy, P., Stankoff, B., Buvat, I., & Bottlaender, M. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.117.195396 · Cited by 63 · see citing works
The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis
Daugherty, D. J., Chechneva, O., Mayrhofer, F., & Deng, W. (2016) · Scientific Reports · doi:10.1038/srep22556 · Cited by 36 · see citing works
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Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression
Xian, X., Cai, L.-L., Li, Y., Wang, R.-C., Xu, Y.-H., Chen, Y.-J., Xie, Y.-H., Zhu, X.-L., & Li, Y.-F. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01332-w · Cited by 169 · see citing works
Friesen, E., Hari, K., Sheft, M., Thiessen, J. D., & Martin, M. (2024) · Magnetic Resonance Materials in Physics, Biology and Medicine · doi:10.1007/s10334-024-01160-z · Cited by 7 · see citing works
- Authors
- Zinnhardt, B., Belloy, M., Fricke, I. B., Orije, J., Guglielmetti, C., Hermann, S., Wagner, S., Schäfers, M., Van der Linden, A., & Jacobs, A. H.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2019
- Volume
- 9
- Issue
- 6
- Pages
- 1523-1537
- ISSN
- 1838-7640
- PMC
- PMC6485187
- Cited by
- 30
- References
- 9
- Language
- en
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