Micro MRI of the mouse brain using a novel 400 MHz cryogenic quadrature RF probe
Abstract
The increasing number of mouse models of human disease used in biomedical research applications has led to an enhanced interest in non‐invasive imaging of mice, e.g. using MRI for phenotyping. However, MRI of small rodents puts high demands on the sensitivity of data acquisition. This requirement can be addressed by using cryogenic radio‐frequency (RF) detection devices. The aim of this work was to investigate the in vivo performance of a 400 MHz cryogenic transmit/receive RF probe (CryoProbe) designed for MRI of the mouse brain. To characterize this novel probe, MR data sets were acquired with both the CryoProbe and a matched conventional receive‐only surface coil operating at room temperature (RT) using conventional acquisition protocols (gradient and spin echo) with identical parameter settings. Quantitative comparisons in phantom and in vivo experiments revealed gains in the signal‐to‐noise ratio (SNR) of 2.4 and 2.5, respectively. The increased sensitivity of the CryoProbe was invested to enhance the image quality of high resolution structural images acquired in scan times compatible with routine operation (< 45 min). In high resolution (30 × 30 × 300 µm 3) structural images of the mouse cerebellum, anatomical details such as Purkinje cell and molecular layers could be identified. Similarly, isotropic (60 × 60 × 60 µm 3) imaging of mouse cortical and subcortical areas revealed anatomical structures smaller than 100 µm. Finally, 3D MR angiography (52 × 80 × 80 µm 3) of the brain vasculature enabled the detailed reconstruction of intracranial vessels (anterior and middle cerebral artery). In conclusion, this low temperature detection device represents an attractive option to increase the performance of small animal MR systems operating at 9.4 Tesla. Copyright © 2009 John Wiley & Sons, Ltd.
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Previous DTI studies assessing microstructural changes in rTg4510 mice produced conflicting results.
“Previous DTI studies assessing microstructural changes in rTg4510 mice, which express transgenic tau P301L mutations driven by a Ca 2+ / calmodulin kinase II promoter system [30,31] in the white and grey matter produced conflicting results [33][34][35][36].”
From Diffusion tensor imaging reveals whole-brain microstructural changes in the P301L mouse model of tauopathy. (2020) · cites this paper as [33]
Effects of tauopathy on DTI metrics in grey and white matter are complex and may involve axonal damage, myelin injury, neuronal degeneration, and gliosis, which all have been found in tauopathies.
“Effects of tauopathy on DTI metrics in the grey and white matter are complex and may involve axonal damage, myelin injury, neuronal degeneration, and gliosis, which all have been found in tauopathies [17,18,23,25,28,29,33,38,57].”
From Diffusion tensor imaging reveals whole-brain microstructural changes in the P301L mouse model of tauopathy. (2020) · cites this paper as [33]
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- Authors
- Baltes, C., Radzwill, N., Bosshard, S., Marek, D., & Rudin, M.
- Affiliations
- University of Zurich (CH)
- Bruker (Switzerland) (CH)
- Corresponding author
- Baltes, Christof
- ORCID
- Rudin, Markus
- Venue
- NMR in Biomedicine
- Publisher
- Wiley
- Published
- 2009-06-17
- Volume
- 22
- Issue
- 8
- Pages
- 834-842
- ISSN
- 0952-3480 (ISSN-L)
- 1099-1492
- OpenAlex
- W2148369313
- Semantic Scholar
- 45bbbcc077777d4aad7bb3e2c4f5428eb01bd6a0
- Cited by
- 149
- References
- 35
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 3 · 2022: 5 · 2021: 10 · 2020: 12 · 2019: 9 · 2018: 13 · 2017: 9 · 2016: 6 · 2015: 12 · 2014: 9 · 2013: 8 · 2012: 13
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NMR in Biomedicine (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Swiss National Science Foundation SNF (3100A0-112835)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Chemistry › Spectroscopy › Advanced NMR Techniques and Applications
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Atomic and Subatomic Physics Research
- Keywords
- small animal MRI, signal-to-noise ratio, cerebellum, cerebral cortex, magnetic resonance angiography, intracranial vasculature, Purkinje cells, 9.4 Tesla
- MeSH terms
- Animals, Brain, Cerebrovascular Circulation, Cold Temperature, Humans, Image Enhancement, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Radio Waves, Mice
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