The DOI matches its Crossref record; 150 of the 150 references it cites were found in a registry or an index.
Alliance with EPR Effect: Combined Strategies to Improve the EPR Effect in the Tumor Microenvironment
Open accessAbstract
The use of nanomedicine for cancer treatment takes advantage of its preferential accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The development of cancer nanomedicine has promised highly effective treatment options unprecedented by standard therapeutics. However, the therapeutic efficacy of passively targeted nanomedicine is not always satisfactory because it is largely influenced by the heterogeneity of the intensity of the EPR effect exhibited within a tumor, at different stages of a tumor, and among individual tumors. In addition, limited data on EPR effectiveness in human hinders further clinical translation of nanomedicine. This unsatisfactory therapeutic outcome in mice and humans necessitates novel approaches to improve the EPR effect. This review focuses on current attempts at overcoming the limitations of traditional EPR-dependent nanomedicine by incorporating supplementary strategies, such as additional molecular targeting, physical alteration, or physiological remodeling of the tumor microenvironment. This review will provide valuable insight to researchers who seek to overcome the limitations of relying on the EPR effect alone in cancer nanomedicine and go "beyond the EPR effect".
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Cites
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Cited by
Shi, Y., van der Meel, R., Chen, X., & Lammers, T. (2020) · Theranostics · doi:10.7150/thno.49577 · Cited by 868
Mendes, B. B., Conniot, J., Avital, A., Yao, D., Jiang, X., Zhou, X., Sharf-Pauker, N., Xiao, Y., Adir, O., Liang, H., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00104-y · Cited by 719
Design of therapeutic biomaterials to control inflammation
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Magnetic nanoparticles in biomedical applications: A review
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Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation
Dhoundiyal, S., Srivastava, S., Kumar, S., Singh, G., Ashique, S., Pal, R., Mishra, N., & Taghizadeh-Hesary, F. (2024) · European Journal of Medical Research · doi:10.1186/s40001-023-01627-0 · Cited by 144
“Passive targeting is a sophisticated method in the field of radiopharmaceuticals, and it becomes particularly intriguing when we delve into the concept of Enhanced Permeability and Retention (EPR) [16].”
Method
Metadata
- Authors
- Park, J., Choi, Y., Chang, H., Um, W., Ryu, J. H., & Kwon, I. C.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2019
- Volume
- 9
- Issue
- 26
- Pages
- 8073-8090
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W2982701461
- Cited by
- 382
- References
- 150
- FWCI
- 10.87
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Alliance with EPR Effect: Combined Strategies to Improve the EPR Effect in the Tumor Microenvironment. https://app.cochat.ai/papers/10.7150/thno.37198
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- Park, J., Choi, Y., Chang, H., Um, W., Ryu, J. H., & Kwon, I. C. (2019). Alliance with EPR Effect: Combined Strategies to Improve the EPR Effect in the Tumor Microenvironment. Theranostics. https://doi.org/10.7150/thno.37198
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
