The DOI matches its Crossref record; 394 of the 394 references it cites were found in a registry or an index.
Selective autophagy of intracellular organelles: Recent research advances
Open accessAbstract
Macroautophagy (hereafter called autophagy) is a highly conserved physiological process that degrades over-abundant or damaged organelles, large protein aggregates and invading pathogens via the lysosomal system (the vacuole in plants and yeast).Autophagy is generally induced by stress, such as oxygen-, energy-or amino acid-deprivation, irradiation, drugs, etc.In addition to non-selective bulk degradation, autophagy also occurs in a selective manner, recycling specific organelles, such as mitochondria, peroxisomes, ribosomes, endoplasmic reticulum (ER), lysosomes, nuclei, proteasomes and lipid droplets (LDs).This capability makes selective autophagy a major process in maintaining cellular homeostasis.The dysfunction of selective autophagy is implicated in neurodegenerative diseases (NDDs), tumorigenesis, metabolic disorders, heart failure, etc. Considering the importance of selective autophagy in cell biology, we systemically review the recent advances in our understanding of this process and its regulatory mechanisms.We emphasize the 'cargo-ligand-receptor' model in selective autophagy for specific organelles or cellular components in yeast and mammals, with a focus on mitophagy and ER-phagy, which are finely described as types of selective autophagy.Additionally, we highlight unanswered questions in the field, helping readers focus on the research blind spots that need to be broken.
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1 retracted
RETRACTED ARTICLE: Parkin and PINK1 mitigate STING-induced inflammation
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The pivotal role of dysregulated autophagy in the progression of non-alcoholic fatty liver disease
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Metadata
- Authors
- Li, W., He, P., Huang, Y., Li, Y.-F., Lu, J., Li, M., Kurihara, H., Luo, Z., Meng, T., Onishi, M., Ma, C., Jiang, L., Hu, Y., Gong, Q., Zhu, D., Xu, Y., Liu, R., Liu, L., Yi, C., Zhu, Y., Ma, N., Okamoto, K., Xie, Z., Liu, J., He, R.-R., & Feng, D.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2021
- Volume
- 11
- Issue
- 1
- Pages
- 222-256
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W3092107442
- Cited by
- 507
- References
- 394
- FWCI
- 29.34
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Li, W., He, P., Huang, Y., Li, Y.-F., Lu, J., Li, M., Kurihara, H., Luo, Z., Meng, T., Onishi, M., Ma, C., Jiang, L., Hu, Y., Gong, Q., Zhu, D., Xu, Y., Liu, R., Liu, L., Yi, C., . . . Feng, D. (2021). Selective autophagy of intracellular organelles: Recent research advances. Theranostics. https://doi.org/10.7150/thno.49860
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