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Cited by 165Extracellular vesicles in diseaseMesenchymal stem cell researchNeuroinflammation and Neurodegeneration Mechanisms

New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)

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Palanisamy, Chella Perumal, Pei, JinJin, Alugoju, Phaniendra, Anthikapalli, Naga Venkata Anusha, Jayaraman, Selvaraj, Veeraraghavan, Vishnu Priya, Gopathy, Sridevi, Roy, Jeane Rebecca +7 more·2023·Theranostics
DOI 10.7150/thno.83066PMC PMC10405853
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Abstract

Neurodegenerative diseases are characterized by the progressive loss of neurons and intricate interactions between different cell types within the affected regions. Reliable biomarkers that can accurately reflect disease activity, diagnose, and monitor the progression of neurodegenerative diseases are crucial for the development of effective therapies. However, identifying suitable biomarkers has been challenging due to the heterogeneous nature of these diseases, affecting specific subsets of neurons in different brain regions. One promising approach for promoting brain regeneration and recovery involves the transplantation of mesenchymal stem cells (MSCs). MSCs have demonstrated the ability to modulate the immune system, promote neurite outgrowth, stimulate angiogenesis, and repair damaged tissues, partially through the release of their extracellular vesicles (EVs). MSC-derived EVs retain some of the therapeutic characteristics of their parent MSCs, including their ability to regulate neurite outgrowth, promote angiogenesis, and facilitate tissue repair. This review aims to explore the potential of MSC-derived EVs as an emerging therapeutic strategy for neurodegenerative diseases, highlighting their role in modulating disease progression and promoting neuronal recovery. By elucidating the mechanisms by which MSC-derived EVs exert their therapeutic effects, we can advance our understanding and leverage their potential for the development of novel treatment approaches in the field of neurodegenerative diseases.

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  • A growing body of research has illuminated the therapeutic potential of EVs derived from diverse cell types, including MSCs, iPSCs, brain-derived NSCs, ESCs, and dendritic cells.

    “A growing body of research has illuminated the therapeutic potential of EVs derived from a diverse array of cell types [207, 208]. This includes MSCs [209–211], iPSCs [212], brain-derived NSCs [213], embryonic stem cells (ESCs) [214], and dendritic cells (DC) [215].”

    From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [211]

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Authors
Palanisamy, C. P., Pei, J., Alugoju, P., Anthikapalli, N. V. A., Jayaraman, S., Veeraraghavan, V. P., Gopathy, S., Roy, J. R., Janaki, C. S., Thalamati, D., Mironescu, M., Luo, Q., Miao, Y., Chai, Y., & Long, Q.
Affiliations
  • Xian Central Hospital (CN)
  • Shaanxi University of Technology (CN)
  • Chulalongkorn University (TH)
  • Saveetha University (IN)
  • SRM Dental College (IN)
  • Bharath University (IN)
  • Hull Royal Infirmary (GB)
  • Lucian Blaga University of Sibiu (RO)
Corresponding author
Long, Qianfa
ORCID
Venue
Theranostics
Publisher
Ivyspring International Publisher
Published
2023
Volume
13
Issue
12
Pages
4138-4165
ISSN
1838-7640 (ISSN-L)
DOI
10.7150/thno.83066
PMC
PMC10405853
OpenAlex
W4385060003
Cited by
165
References
10
Citations by year
2026: 49 · 2025: 67 · 2024: 48 · 2023: 1
FWCI
4.36
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Theranostics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Greater South Information System
Funders
  • Deutsches Krebsforschungszentrum
  • National Natural Science Foundation of China (82171353, 81871084)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
neurodegenerative diseases, extracellular vesicles, mesenchymal stem cells, stem cell-derived vesicles, biomarkers, neuronal regeneration, neurite outgrowth, angiogenesis, tissue repair, immunomodulation, cell transplantation therapy
MeSH terms
Extracellular Vesicles, Brain, Humans, Neurodegenerative Diseases, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells

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