Bidirectional Brain-Systemic Interactions and Outcomes After TBI
Open accessAbstract
Traumatic brain injury (TBI) is a debilitating disorder associated with chronic progressive neurodegeneration and long-term neurological decline. Importantly, there is now substantial and increasing evidence that TBI can negatively impact systemic organs, including the pulmonary, gastrointestinal (GI), cardiovascular, renal, and immune system. Less well appreciated, until recently, is that such functional changes can affect both the response to subsequent insults or diseases, as well as contribute to chronic neurodegenerative processes and long-term neurological outcomes. In this review, we summarize evidence showing bidirectional interactions between the brain and systemic organs following TBI and critically assess potential underlying mechanisms.
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Traumatic brain injury induces brain inflammation through acute and chronic alterations in immune system and increased susceptibility to infections.
“For example, traumatic brain injury (TBI) induces brain inflammation through acute and chronic alterations in the immune system and increased susceptibility to infections. 107”
From Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies (2024) · cites this paper as [107]
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Additional file 1 of Bi-directional neuro-immune dysfunction after chronic experimental brain injury
Ritzel, R. M., Li, Y., Jiao, Y., Doran, S. J., Khan, N., Henry, R. J., Brunner, K., Loane, D. J., Faden, A. I., Szeto, G. L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25556533
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- Authors
- Faden, A. I., Barrett, J. P., Stoica, B. A., & Henry, R. J.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Faden, Alan I.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 44
- Issue
- 5
- Pages
- 406-418
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC8084884
- OpenAlex
- W3124868398
- Cited by
- 57
- References
- 107
- Citations by year
- 2026: 14 · 2025: 6 · 2024: 14 · 2023: 10 · 2022: 7 · 2021: 6
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Automotive and Human Injury Biomechanics
- Keywords
- traumatic brain injury, neurodegeneration, long-term neurological outcome, pulmonary dysfunction, gastrointestinal dysfunction, cardiovascular dysfunction, renal dysfunction, immune system, bidirectional signaling
- MeSH terms
- Brain Injuries, Traumatic, Animals, Brain, Humans, Mice, Inbred C57BL, Mice, Cognitive Dysfunction
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