Transforming growth factor‐beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

Carpenter, A. E., Jones, T. R., Lamprecht, M. R., Clarke, C., Kang, I. H., Friman, O., Guertin, D. A., Chang, J. H., Lindquist, R. A., Moffat, J., et al. (2006) · Genome biology · doi:10.1186/gb-2006-7-10-r100 · Cited by 5,077 · see citing works

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543 · see citing works

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492 · see citing works

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

Lavin, Y., Winter, D., Blecher-Gonen, R., David, E., Keren-Shaul, H., Merad, M., Jung, S., & Amit, I. (2014) · Cell · doi:10.1016/j.cell.2014.11.018 · Cited by 2,167 · see citing works

A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium

RAFF, M. C., Miller, R. H., & Noble, M. (1983) · Nature · doi:10.1038/303390a0 · Cited by 2,030 · see citing works

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,788 · see citing works

SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7

Inman, G. J., Nicolás, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., Laping, N. J., & Hill, C. S. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.1.65 · Cited by 1,636 · see citing works

The microglial sensome revealed by direct RNA sequencing

Hickman, S. E., Kingery, N. D., Ohsumi, T. K., Borowsky, M. L., Wang, L.-C., Means, T. K., & El Khoury, J. (2013) · Nature Neuroscience · doi:10.1038/nn.3554 · Cited by 1,511 · see citing works

Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis

Chang, A., Tourtellotte, W. W., Rudick, R., & Trapp, B. D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa010994 · Cited by 991 · see citing works

The Neurotoxicant, Cuprizone, as a Model to Study Demyelination and Remyelination in the Central Nervous System

Matsushima, G. K., & Morell, P. (2001) · Brain Pathology · doi:10.1111/j.1750-3639.2001.tb00385.x · Cited by 984 · see citing works

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

Kuhlmann, T., Miron, V., Cuo, Q., Wegner, C., Antel, J., & Bruck, W. (2008) · Brain · doi:10.1093/brain/awn096 · Cited by 864 · see citing works

Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation

Kotter, M. R., Li, W.-W., Zhao, C., & Franklin, R. J. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2615-05.2006 · Cited by 768 · see citing works

Correction: Corrigendum: Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

Yang, J., Huang, T., Petralia, F., Long, Q., Zhang, B., Argmann, C., Zhao, Y. B., Mobbs, C. V., Schadt, E. E., Zhu, J., et al. (2016) · Scientific Reports · doi:10.1038/srep19384 · Cited by 721 · see citing works

Bone Morphogenetic Proteins Promote Astroglial Lineage Commitment by Mammalian Subventricular Zone Progenitor Cells

Gross, R. E., Mehler, M. F., Mabie, P. C., Zang, Z., Santschi, L. A., & Kessler, J. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80193-2 · Cited by 696 · see citing works

CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination

Zawadzka, M., Rivers, L. E., Fancy, S. P. J., Zhao, C., Tripathi, R., Jamen, F., Young, K., Goncharevich, A., Pohl, H., Rizzi, M., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.04.002 · Cited by 650 · see citing works

Rejuvenation of Regeneration in the Aging Central Nervous System

Ruckh, J. M., Zhao, J.-W., Shadrach, J. L., van Wijngaarden, P., Rao, T. N., Wagers, A. J., & Franklin, R. J. M. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2011.11.019 · Cited by 649 · see citing works

Regenerating CNS myelin — from mechanisms to experimental medicines

Franklin, R. J. M., & ffrench-Constant, C. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.136 · Cited by 647 · cited 2× · see citing works

Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542

Laping, N. J., Grygielko, E. T., Mathur, A., Butter, S., Bomberger, J. M., Tweed, C. W., Martin, W., Fornwald, J. A., Lehr, R. V., Harling, J. D., et al. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.1.58 · Cited by 638 · see citing works

The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation

Sim, F. J., Zhao, C., Penderis, J., & Franklin, R. J. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02451.2002 · Cited by 625 · see citing works

Defective cholesterol clearance limits remyelination in the aged central nervous system

Cantuti-Castelvetri, L., Fitzner, D., Bosch-Queralt, M., Weil, M.-T., Su, M., Sen, P., Ruhwedel, T., Mitkovski, M., Trendelenburg, G., Lütjohann, D., et al. (2018) · Science · doi:10.1126/science.aan4183 · Cited by 586 · see citing works

Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells

Wolswijk, G. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00601.1998 · Cited by 498 · see citing works

Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice

Holm, T. M., Habashi, J. P., Doyle, J. J., Bedja, D., Chen, Y., van Erp, C., Lindsay, M. E., Kim, D. S., Schoenhoff, F., Cohn, R. D., et al. (2011) · Science · doi:10.1126/science.1192149 · Cited by 475 · see citing works

Angiotensin II Type 2 Receptor Signaling Attenuates Aortic Aneurysm in Mice Through ERK Antagonism

Habashi, J. P., Doyle, J. J., Holm, T. M., Aziz, H., Schoenhoff, F., Bedja, D., Chen, Y., Modiri, A. N., Judge, D. P., & Dietz, H. C. (2011) · Science · doi:10.1126/science.1192152 · Cited by 472 · see citing works

Remyelination protects axons from demyelination-associated axon degeneration

Irvine, K. A., & Blakemore, W. F. (2008) · Brain · doi:10.1093/brain/awn080 · Cited by 420 · see citing works

Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts.

Roberts, C. J., Birkenmeier, T. M., McQuillan, J. J., Akiyama, S. K., Yamada, S. S., Chen, W. T., Yamada, K. M., & McDonald, J. A. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68822-2 · Cited by 333 · see citing works

Central remyelination restores secure conduction

Smith, K. J., Blakemore, W. F., & MCDONALD, W. I. (1979) · Nature · doi:10.1038/280395a0 · Cited by 332 · see citing works

Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression

Kotter, M. R., Zhao, C., van Rooijen, N., & Franklin, R. J. M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.09.019 · Cited by 331 · see citing works

Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors

Gautier, H. O. B., Evans, K. A., Volbracht, K., James, R., Sitnikov, S., Lundgaard, I., James, F., Lao‐Peregrín, C., Reynolds, R., Franklin, R. J. M., et al. (2015) · Nature Communications · doi:10.1038/ncomms9518 · Cited by 305 · see citing works

NG2+ Glial Cells: A Novel Glial Cell Population in the Adult Brain

Nishiyama, A., Chang, A., & Trapp, B. D. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199911000-00001 · Cited by 297 · see citing works

Bone morphogenetic proteins induce astroglial differentiation of oligodendroglial-astroglial progenitor cells

Mabie, P. C., Mehler, M. F., Marmur, R., Papavasiliou, A., Song, Q., & Kessler, J. A. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04112.1997 · Cited by 294 · see citing works

TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke

Doyle, K. P., Cekanaviciute, E., Mamer, L., & Buckwalter, M. S. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-62 · Cited by 250 · see citing works

A role for TGF-beta in oligodendrocyte differentiation.

McKinnon, R. D., Piras, G., Ida, J. A., & Dubois-Dalcq, M. (1993) · The Journal of cell biology · doi:10.1083/jcb.121.6.1397 · Cited by 248 · see citing works

Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination

Lau, L. W., Keough, M. B., Haylock‐Jacobs, S., Cua, R., Döring, A., Sloka, S., Stirling, D. P., Rivest, S., & Yong, V. W. (2012) · Annals of Neurology · doi:10.1002/ana.23599 · Cited by 248 · see citing works

Relative roles of TGF‐β1 and Wnt in the systemic regulation and aging of satellite cell responses

Carlson, M. E., Conboy, M. J., Hsu, M., Barchas, L., Jeong, J., Agrawal, A., Mikels, A. J., Agrawal, S., Schaffer, D. V., & Conboy, I. M. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00517.x · Cited by 244 · see citing works

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

Natrajan, M. S., de la Fuente, A. G., Crawford, A. H., Linehan, E., Núñez, V., Johnson, K. R., Wu, T., Fitzgerald, D. C., Ricote, M., Bielekova, B., et al. (2015) · Brain · doi:10.1093/brain/awv289 · Cited by 217 · see citing works

An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination

Keough, M. B., Rogers, J. A., Zhang, P., Jensen, S. K., Stephenson, E. L., Chen, T., Hurlbert, M. G., Lau, L. W., Rawji, K. S., Plemel, J. R., et al. (2016) · Nature Communications · doi:10.1038/ncomms11312 · Cited by 212 · see citing works

Diffusion barriers evoked in the rat cortex by reactive astrogliosis

Roitbak, T., & Sykov�, E. (1999) · Glia · doi:10.1002/(sici)1098-1136(199910)28:1 · Cited by 208 · see citing works

Fibronectin aggregation in multiple sclerosis lesions impairs remyelination

Stoffels, J. M. J., de Jonge, J. C., Stancic, M., Nomden, A., van Strien, M. E., Ma, D., Šišková, Z., Maier, O., ffrench‐Constant, C., Franklin, R. J. M., et al. (2013) · Brain · doi:10.1093/brain/aws313 · Cited by 206 · see citing works

Brain pericytes acquire a microglial phenotype after stroke

Özen, Í., Deierborg, T., Miharada, K., Padel, T., Englund, E. M., Genové, G., & Paul, G. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1295-x · Cited by 201 · see citing works

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage

Petersen, M. A., Ryu, J. K., Chang, K.-J., Etxeberría, A., Bardehle, S., Mendiola, A. S., Kamau-Devers, W., Fancy, S. P. J., Thor, A., Bushong, E. A., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.008 · Cited by 198 · see citing works

Macrophages and CNS remyelination

Miron, V. E., & Franklin, R. J. M. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12705 · Cited by 196 · see citing works

Myelinogenic Plasticity of Oligodendrocyte Precursor Cells following Spinal Cord Contusion Injury

Assinck, P., Duncan, G. J., Plemel, J. R., Lee, M. J., Stratton, J. A., Manesh, S. B., Liu, J., Ramer, L. M., Kang, S. H., Bergles, D. E., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2409-16.2017 · Cited by 151 · see citing works

Chronically Increased Transforming Growth Factor-β1 Strongly Inhibits Hippocampal Neurogenesis in Aged Mice

Buckwalter, M. S., Yamane, M., Coleman, B. S., Ormerod, B. K., Chin, J. T., Palmer, T. D., & Wyss‐Coray, T. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051272 · Cited by 141 · see citing works

Cell-Mediated Neuroprotection in a Mouse Model of Human Tauopathy

Hampton, D. W., Webber, D. J., Bilican, B., Goedert, M., Spillantini, M. G., & Chandran, S. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0834-10.2010 · Cited by 129 · see citing works

Expression of Transforming Growth Factor (TGF)-β1, -β2, and -β3 Isoforms and TGF-β Type I and Type II Receptors in Multiple Sclerosis Lesions and Human Adult Astrocyte Cultures

Groot, C. J. A. D., Montagne, L., Barten, A. D., Sminia, P., & van der Valk, P. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199902000-00007 · Cited by 128 · see citing works

TGF Signaling Regulates the Timing of CNS Myelination by Modulating Oligodendrocyte Progenitor Cell Cycle Exit through SMAD3/4/FoxO1/Sp1

Palazuelos, J., Klingener, M., & Aguirre, A. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0363-14.2014 · Cited by 110 · see citing works

Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination

Redmond, S., Mei, F., Eshed‐Eisenbach, Y., Osso, L. A., Leshkowitz, D., Shen, Y. A., Kay, J. N., Aurrand‐Lions, M., Lyons, D. A., Peles, E., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.07.021 · Cited by 106 · see citing works

Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination

Yuen, T. J., Johnson, K. R., Miron, V. E., Zhao, C., Quandt, J., Harrisingh, M. C., Swire, M., Williams, A., McFarland, H. F., Franklin, R. J. M., et al. (2013) · Brain · doi:10.1093/brain/awt024 · Cited by 80 · see citing works

Blood levels of transforming growth factor-beta 1 (TGF-β1) are elevated in both relapsing remitting and chronic progressive multiple sclerosis (MS) patients and are further augmented by treatment with interferon-beta 1b (IFN-β1b)

Nicoletti, F., Marco, R. D., Patti, F., Reggio, E., Nicoletti, A. S. Q., Zaccone, P., Stivala, F., Meroni, P. L., & Reggio, A. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00604.x · Cited by 78 · see citing works

Activated microglia in a rat stroke model express NG2 proteoglycan in peri‐infarct tissue through the involvement of TGF‐β1

Sugimoto, K., Nishioka, R., Ikeda, A., Mise, A., Takahashi, H., Yano, H., Kumon, Y., Ohnishi, T., & Tanaka, J. (2013) · Glia · doi:10.1002/glia.22598 · Cited by 70 · see citing works

Regenerative Capacity of Macrophages for Remyelination

Rawji, K. S., Mishra, M. K., & Yong, V. W. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00047 · Cited by 67 · see citing works

Oligodendrocyte Progenitors Reversibly Exit the Cell Cycle and Give Rise to Astrocytes in Response to Interferon-γ

Tanner, D. C., Cherry, J. D., & Mayer‐Pröschel, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5905-10.2011 · Cited by 50 · see citing works

Cellular and Molecular Mechanisms Underpinning Macrophage Activation during Remyelination

Lloyd, A. F., & Miron, V. E. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00060 · Cited by 35 · see citing works

Microglia/monocytes with NG2 expression have no phagocytic function in the cortex after LPS focal injection into the rat brain

Zhu, L., Xiang, P., Guo, K., Wang, A., Lu, J., Tay, S. S. W., Jiang, H., & He, B. P. (2012) · Glia · doi:10.1002/glia.22362 · Cited by 25 · see citing works

NG2 expression in microglial cells affects the expression of neurotrophic and proinflammatory factors by regulating FAK phosphorylation

Zhu, L., Su, Q., Jie, X., Liu, A., Wang, H., He, B., & Jiang, H. (2016) · Scientific Reports · doi:10.1038/srep27983 · Cited by 22 · see citing works

Untitled work

(1999) · doi:10.1002/(sici)1098-1136(19990201)25:3

Ageing and rejuvenation of tissue stem cells and their niches

Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00510-w · Cited by 407 · see citing works

The Cuprizone Model: Dos and Do Nots

Zhan, J., Mann, T., Joost, S., Behrangi, N., Frank, M., & Kipp, M. (2020) · Cells · doi:10.3390/cells9040843 · Cited by 171 · see citing works

New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)

Palanisamy, C. P., Pei, J., Alugoju, P., Anthikapalli, N. V. A., Jayaraman, S., Veeraraghavan, V. P., Gopathy, S., Roy, J. R., Janaki, C. S., Thalamati, D., et al. (2023) · Theranostics · doi:10.7150/thno.83066 · Cited by 165 · see citing works

Aging microglia

Antignano, I., Liu, Y., Offermann, N., & Capasso, M. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04775-y · Cited by 117 · see citing works

Roles and regulation of microglia activity in multiple sclerosis: insights from animal models

Distéfano‐Gagné, F., Bitarafan, S., Lacroix, S., & Gosselin, D. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00709-6 · Cited by 112 · see citing works

Cellular senescence, DNA damage, and neuroinflammation in the aging brain

Zhang, W., Sun, H., Wang, X., Dumont, A. S., & Liu, Q. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.04.003 · Cited by 113 · see citing works

White matter microglia heterogeneity in the CNS

Amor, S., McNamara, N. B., Gerrits, E., Marzin, M. C., Kooistra, S. M., Miron, V. E., & Nutma, E. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02389-x · Cited by 89 · see citing works

Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination

Bosch-Queralt, M., Cantuti-Castelvetri, L., Damkou, A., Schifferer, M., Schlepckow, K., Alexopoulos, I., Lütjohann, D., Klose, C., Vaculčiaková, L., Masuda, T., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00341-7 · Cited by 88 · see citing works

Diversity and Function of Glial Cell Types in Multiple Sclerosis

Schirmer, L., Schafer, D. P., Bartels, T., Rowitch, D. H., & Calabresi, P. A. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.01.005 · Cited by 75 · see citing works

Microglia Diversity in Health and Multiple Sclerosis

Zia, S., Rawji, K. S., Michaels, N. J., Burr, M. K., Kerr, B. J., Healy, L. M., & Plemel, J. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.588021 · Cited by 69 · see citing works

Molecular Mechanisms of Immunosenescene and Inflammaging: Relevance to the Immunopathogenesis and Treatment of Multiple Sclerosis

Perdaens, O., & Pesch, V. V. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.811518 · Cited by 59 · see citing works

Glial Cells Promote Myelin Formation and Elimination

Hughes, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.661486 · Cited by 58 · see citing works

Acute brain injuries trigger microglia as an additional source of the proteoglycan NG2

Huang, W., Bai, X., Meyer, E., & Scheller, A. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01016-2 · Cited by 47 · see citing works

Glial aging and its impact on central nervous system myelin regeneration

Rawji, K. S., Neumann, B., & Franklin, R. J. M. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14933 · Cited by 46 · see citing works

Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination

de la Fuente, A. G., Dittmer, M., Heesbeen, E. J., Gallardo, N. D. L. V., White, J. A., Young, A., McColgan, T., Dashwood, A., Mayne, K., Cabeza‐Fernández, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45742-w · Cited by 46 · see citing works

The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination

McMurran, C. E., Guzman de la Fuente, A., Penalva, R., Ben Menachem-Zidon, O., Dombrowski, Y., Falconer, J., Gonzalez, G. A., Zhao, C., Krause, F. N., Young, A. M. H., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1905787116 · Cited by 39 · see citing works

Psychological Stress as a Risk Factor for Accelerated Cellular Aging and Cognitive Decline: The Involvement of Microglia-Neuron Crosstalk

Carrier, M., Šimončičová, E., St‐Pierre, M., McKee, C., & Tremblay, M. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.749737 · Cited by 37 · see citing works

Cellular senescence and failure of myelin repair in multiple sclerosis

Koutsoudaki, P. N., Papadopoulos, D., Passias, P.-G., Koutsoudaki, P., & Gorgoulis, V. G. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111366 · Cited by 32 · see citing works

Macroglial diversity: white and grey areas and relevance to remyelination

Werkman, I. L., Lentferink, D. H., & Baron, W. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03586-9 · Cited by 32 · see citing works

BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis

Petersen, M. A., Tognatta, R., Meyer‐Franke, A., Bushong, E. A., Mendiola, A. S., Yan, Z., Muthusamy, A., Merlini, M., Meza-Acevedo, R., Cabriga, B., et al. (2021) · Brain · doi:10.1093/brain/awab106 · Cited by 28 · see citing works

Biological agents and the aging brain: glial inflammation and neurotoxic signaling

Latham, A. S., Moreno, J. A., & Geer, C. E. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1244149 · Cited by 25 · see citing works

TGFB1-Mediated Gliosis in Multiple Sclerosis Spinal Cords Is Favored by the Regionalized Expression of HOXA5 and the Age-Dependent Decline in Androgen Receptor Ligands

Nataf, S., Guillen, M., & Pays, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20235934 · Cited by 23 · see citing works

Endogenous Neural Stem Cell Mediated Oligodendrogenesis in the Adult Mammalian Brain

Radecki, D. Z., & Samanta, J. (2022) · Cells · doi:10.3390/cells11132101 · Cited by 21 · see citing works

Neuroinflammation in Demyelinating Diseases: Oxidative Stress as a Modulator of Glial Cross-Talk

Varas, R., & Ortíz, F. C. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191216125725 · Cited by 21 · see citing works

Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders

Conejos‐Sánchez, I., Gallon, E., Niño‐Pariente, A., Smith, J. A., de la Fuente, A. G., Canio, L. D., Pluchino, S., Franklin, R. J. M., & Vicent, M. J. (2019) · Nanoscale · doi:10.1039/c9nr06187h · Cited by 20 · see citing works

Bone Tissue and the Nervous System: What Do They Have in Common?

Minoia, A., Carbonare, L. D., Schwamborn, J. C., Bolognin, S., & Valenti, M. T. (2022) · Cells · doi:10.3390/cells12010051 · Cited by 19 · see citing works

Understanding Multiple Sclerosis Pathophysiology and Current Disease-Modifying Therapies: A Review of Unaddressed Aspects.

Mohammed, E. M. A. (2024) · Frontiers in Bioscience · doi:10.31083/j.fbl2911386 · Cited by 20 · see citing works

Glial-derived transforming growth factor β1 (TGF-β1): a key factor in multiple sclerosis neuroinflammation

Guevara, C., & Ortíz, F. C. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.293147 · Cited by 17 · see citing works

<i> Cspg4 ^high </i> microglia contribute to microgliosis during neurodegeneration

Liu, Y.-J., Ding, Y., Yin, Y.-Q., Xiao, H., Hu, G., & Zhou, J.-W. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2210643120 · Cited by 14 · see citing works

Depletion of regulatory T cells exacerbates inflammatory responses after chronic cerebral hypoperfusion in mice

Wang, Y., Wu, Q., Fang, Y., Song, G., Xu, L., Wang, W., Pan, D., & Xie, M. (2022) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2022.103788 · Cited by 12 · see citing works

Enhancing axonal myelination in seniors: A review exploring the potential impact cannabis has on myelination in the aged brain

Murray, C. J., Vecchiarelli, H. A., & Tremblay, M. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1119552 · Cited by 12 · see citing works

Cellular Components of the Blood-Brain Barrier and Their Involvement in Aging-Associated Cognitive Impairment

Shen, K., Shi, Y., Wang, X., & Leung, S. W. S. (2024) · Aging and Disease · doi:10.14336/ad.202.0424 · Cited by 11 · see citing works

Role and Mechanism of Microglia in White Matter Injury Recovery in Ischemic Stroke

Guo, Y., Shang, Y., Yao, J., & Bi, X. (2025) · Immunity Inflammation and Disease · doi:10.1002/iid3.70226 · Cited by 10 · see citing works

Recent updates on mechanisms of cell-cell interaction in oligodendrocyte regeneration after white matter injury

Ohtomo, R., & Arai, K. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134650 · Cited by 9 · see citing works

Role of transforming growth factorβ in neurovascular unit during cerebral small vessel disease

Li, Y., Cai, Y., Xie, K., Hu, F., Li, J., Li, C., Zhang, R., & Zhong, Z. (2025) · Fluids and Barriers of the CNS · doi:10.1186/s12987-025-00713-1 · Cited by 7 · see citing works

The Demonstration of an Aqp4/Tgf-Beta 1 Pathway in Murine Astrocytes Holds Implications for Both Neuromyelitis Optica and Progressive Multiple Sclerosis

Nataf, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031035 · Cited by 7 · see citing works

Failed resolution of inflammation in intracerebral haemorrhage

Cao, L., Zhao, W., Zhang, Y., Pi, W., Yong, V. W., & Xue, M. (2026) · Nature Reviews Neurology · doi:10.1038/s41582-026-01227-6 · Cited by 3 · see citing works

The age-dependent neuroglial interaction with peripheral immune cells in coronavirus-induced neuroinflammation with a special emphasis on COVID-19

Ghosh, S., & Sarma, J. D. (2025) · Biogerontology · doi:10.1007/s10522-025-10252-9 · Cited by 3 · see citing works

Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelinationPreprint

de la Fuente, A. G., Dittmer, M., Heesbeen, E. J., Gallardo, N. D. L. V., White, J. A., Young, A., McColgan, T., Dashwood, A., Mayne, K., Cabeza‐Fernández, S., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.25.525562 · Cited by 3 · see citing works

Effect of transplanted oligodendrocyte precursor cells derived from inflammatory and non-inflammatory microenvironment on remyelination in a chronic cuprizone model

Akbari, H., Kashani, I. R., Yazdi, F. R., & Pasbakhsh, P. (2026) · PLoS ONE · doi:10.1371/journal.pone.0343039 · Cited by 2 · see citing works

Microglia in diffuse midline glioma contribute to extracellular matrix remodelling and cancer cell invasion

Keane, L., Škandík, M., Posada-Pérez, M., Bose, R., Desito, J., van der Linde, E., Engskog‐Vlachos, P., Ceccatelli, S., Green, A. L., & Joseph, B. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08891-y · Cited by 2 · see citing works

HB-EGF and EGF infusion following CNS demyelination mitigates age-related decline in regeneration of oligodendrocytes from neural precursor cells originating in the ventricular-subventricular zonePreprint

Moradi, K., Mitew, S., Xing, Y. L., & Merson, T. D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.26.582092 · Cited by 2 · see citing works

Microglial Senescence in Neurodegenerative Diseases: Mechanisms and Therapeutic Perspectives

Liu, Y., Hu, Z., Xiao, Y., Han, X., Cheng, X., & Ye, T. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6c00016 · Cited by 1 · see citing works

Profiling miRNAs Involved in Human Oligodendrocyte Precursor Cell Differentiation and Maturation

Barzegar, M., Dhukhwa, A., Patel, V. N., Velásquez, F. C., Das, S., Patil, A. H., Halushka, M. K., Zack, D. J., & Chamling, X. (2026) · Cells · doi:10.3390/cells15151343 · Cited by 1 · see citing works

Neuronal and microglial interactions with oligodendrocytes regulate myelin sheath formation and elimination

Hughes, A. (2020) · doi:10.25677/72qa-5t41

Cholesterol metabolism in mouse models of Multiple Sclerosis

Berghoff, S. A. (2020) · doi:10.53846/goediss-8239

Gliovascular Mechanisms and White Matter Injury in Vascular Cognitive Impairment and Dementia

Rosenberg, G. A., Maki, T., Arai, K., & Lo, E. H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-69424-7.00013-2

Cellular senescence in the ageing brain

Talma, N. (2022) · doi:10.33612/diss.206630102

Efeito de antipsicóticos e canabidiol em cultura de oligodendrócitos tratados com cuprizona

Falvella, A. C. B. (2020) · doi:10.47749/t/unicamp.2020.1157758

Additional file 1 of Acute brain injuries trigger microglia as an additional source of the proteoglycan NG2

Huang, W., Bai, X., Meyer, E., & Scheller, A. (2020) · Figshare · doi:10.6084/m9.figshare.12864347

Comparative Analysis of Mouse CSF Proteins in Experimental Autoimmune Encephalomyelitis Model and Cuprizone-Induced Demyelination Model by Olink Proteomics

Bernaerts, E., Rutten, M., Visscher, A. D., Beliën, J., Berghmans, N., Mitera, T., Somer, L. D., Matthys, P., & Vandooren, J. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05905-w

The molecular asynchrony of single cellsPreprint

Fu, B., Tan, R., Cao, Z., Bai, X., Bai, D., Song, J., & Zhu, C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.02.729594

Crosstalk Between Oligodendrocyte Lineage Cells and CNS ‐Resident and Peripheral Immune Cells Governs Demyelination and Remyelination in Multiple Sclerosis

Park, J., Cheon, S. Y., & Guo, F. (2026) · Glia · doi:10.1002/glia.70211

TGFβ Participation in the Remyelination Process Through Microglial Modulation and Oligodendrocyte Maturation

Pinto, L. I. G., Adamo, A. M., & Mathieu, P. (2025) · BioFactors · doi:10.1002/biof.70051 · Cited by 2 · see citing works

Microglia Impede Oligodendrocyte Generation in Aged Brain

Luan, W., Qi, X., Liang, F., Zhang, X., Jin, Z., Shi, L., Luo, B., & Dai, X. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s338242 · Cited by 31 · see citing works

The age‐related decrease in CNS remyelination efficiency is caused by an impairment of both oligodendrocyte progenitor recruitment and differentiation

Zhao, C., Sim, F. J., Penderis, J., & Franklin, R. J. M. (2002) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2002.39286_16.x · Cited by 1 · see citing works

The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation

Sim, F. J., Zhao, C., Penderis, J., & Franklin, R. J. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02451.2002 · Cited by 625 · see citing works

TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration

Zhu, K., Liu, Y., Min, J.-H., Joshua, V., Lin, J., Li, Y., Kreutzmann, J. C., Guo, Y., Xia, W., Mohammadi, E., et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-025-02161-4 · Cited by 11 · see citing works