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Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity.
Open accessAbstract
Lipstatin, a new and very potent inhibitor of pancreatic lipase (the key enzyme of intestinal fat digestion) was isolated from Streptomyces toxytricini. Lipstatin contains a beta-lactone structure that probably accounts for the irreversible lipase inhibition. The IC50 of lipstatin for pancreatic lipase is 0.14 microM. In mice triolein absorption was dose-dependently inhibited by lipstatin, whereas oleic acid was absorbed normally. Other pancreatic enzymes, such as phospholipase A2 and trypsin, were not inhibited even at an inhibitor concentration of 200 microM.
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Metadata
- Authors
- WEIBEL, E. K., HADVARY, P., HOCHULI, E., KUPFER, E., & LENGSFELD, H.
- Venue
- The Journal of Antibiotics
- Published
- 1987
- Volume
- 40
- Issue
- 8
- Pages
- 1081-1085
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W2510236000
- Cited by
- 341
- References
- 0
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. https://app.cochat.ai/papers/10.7164/antibiotics.40.1081
- The paper
- WEIBEL, E. K., HADVARY, P., HOCHULI, E., KUPFER, E., & LENGSFELD, H. (1987). Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. The Journal of Antibiotics. https://doi.org/10.7164/antibiotics.40.1081
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
