Possible anti-obesity therapeutics from nature--a review

Yun, Jong Won

doi:10.1016/j.phytochem.2010.07.011

Cited by 624Pharmacology and Obesity TreatmentBioactive natural compoundsMedicinal Plant Research

Possible anti-obesity therapeutics from nature--a review

Yun, Jong Won·2010·Phytochemistry

DOI 10.1016/j.phytochem.2010.07.011

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Abstract

Obesity is associated with many diseases, particularly diabetes, hypertension, osteoarthritis, and heart disease. The obesity incidence has increased at an alarming rate in recent years, becoming a worldwide health problem, with incalculable social costs. Two different obesity-treatment drugs are currently on the market: orlistat, which reduces intestinal fat absorption via inhibiting pancreatic lipase; and sibutramine, an anorectic or appetite suppressant. Both drugs have hazardous side-effects, including increased blood pressure, dry mouth, constipation, headache, and insomnia. For this reason, a wide variety of natural materials have been explored for their obesity treatment potential. These are mainly complex products having several components with different chemical and pharmacological features. This review aimed to survey the literature covering natural products with anti-obesity activity and to review the scientific data, including experimental methodologies, active components, and mechanisms of action against obesity.

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Lipase inhibitors can effectively reduce fat absorption to suppress weight gain in obese patients.
“Previous reports have shown that lipase inhibitors can effectively reduce fat absorption to suppress weight gain in obese patients [13,18].”
From Separation and Lipid Inhibition Effects of a Novel Decapeptide from Chlorella pyenoidose (2019) · cites this paper as [13]
Inhibition of pancreatic lipase decreases the absorption of lipids, which can reduce obesity.
“Therefore, inhibition of pancreatic lipase decreases the absorption of lipids, which can reduce obesity [11,12,13].”
From Separation and Lipid Inhibition Effects of a Novel Decapeptide from Chlorella pyenoidose (2019) · cites this paper as [13]

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Extraction and quantification of saponins: A review
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Biological Properties and Bioactive Components of Allium cepa L.: Focus on Potential Benefits in the Treatment of Obesity and Related Comorbidities
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Dietary supplementation with purified mulberry (Morus australis Poir) anthocyanins suppresses body weight gain in high-fat diet fed C57BL/6 mice
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Blueberry and Mulberry Juice Prevent Obesity Development in C57BL/6 Mice
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Procyanidin B2 ameliorates free fatty acids-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state
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Preventive and ameliorating effects of citrus d-limonene on dyslipidemia and hyperglycemia in mice with high-fat diet-induced obesity
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Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials
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Managing obesity through natural polyphenols: A review
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Inhibitory effects of chickpea and Tribulus terrestris on lipase, α-amylase and α-glucosidase
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Targeting metabolic disorders by natural products
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Effects and mechanisms of edible and medicinal plants on obesity: an updated review
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Potential of Natural Products in the Inhibition of Adipogenesis through Regulation of PPARγ Expression and/or Its Transcriptional Activity
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Anti-Obesity and Anti-Diabetic Effect of Neoagarooligosaccharides on High-Fat Diet-Induced Obesity in Mice
Hong, S. J., Lee, J.-H., Kim, E. J., Yang, H. J., Park, J.-S., & Hong, S. (2017) · Marine Drugs · doi:10.3390/md15040090 · Cited by 106 · see citing works
Anti-obesity effects of galangin, a pancreatic lipase inhibitor in cafeteria diet fed female rats
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Antiobesity and lipid lowering effects of theaflavins on high-fat diet induced obese rats
Jin, D., Xu, Y., Mei, X., Meng, Q., Gao, Y., Li, B., & Tu, Y. (2013) · Journal of Functional Foods · doi:10.1016/j.jff.2013.03.011 · Cited by 105 · see citing works
Multi-Functional Roles of Chitosan as a Potential Protective Agent against Obesity
Walsh, A. M., Sweeney, T., Bahar, B., & O’Doherty, J. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053828 · Cited by 104 · see citing works
Novel insights in health-promoting properties of sweet cherries
Faienza, M. F., Corbo, F., Carocci, A., Catalano, A. A., Clodoveo, M. L., Grano, M., Wang, D. Q. ‐., D’Amato, G., Muraglia, M., Franchini, C., et al. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103945 · Cited by 100 · see citing works
2: Phenolic Compounds Potential Health Benefits and Toxicity
Street, R. A., Prinsloo, G., & McGaw, L. J. (2017) · CRC Press eBooks · doi:10.1201/9781315151540-3 · Cited by 98 · see citing works
Inhibition of Gastric Lipase as a Mechanism for Body Weight and Plasma Lipids Reduction in Zucker Rats Fed a Rosemary Extract Rich in Carnosic Acid
Romo‐Vaquero, M., Yáñez-Gascón, M. J., Garcı́a-Villalba, R., Larrosa, M., Fromentin, E., Ibarra, A., Roller, M., Tomás-Barberán, F. A., Espı́n, J. C., & García‐Conesa, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039773 · Cited by 99 · see citing works
Inhibitory effects of sweet cherry anthocyanins on the obesity development in C57BL/6 mice
Wu, T., Tang, Q., Yu, Z., Gao, Z., Hu, H., Chen, W., Zheng, X., & Yu, T. (2013) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2013.854749 · Cited by 98 · see citing works
Freeze-dried jaboticaba peel powder improves insulin sensitivity in high-fat-fed mice
Dragano, N. R. V., Marques, A. Y. C., Cintra, D. E., Solon, C., Morari, J., Leite, A. V., Velloso, L. A., & Maróstica, M. R. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114512005090 · Cited by 98 · see citing works
Review Article: Herbal Approach for Obesity Management
Chandrasekaran, C. V., Vijayalakshmi, M. A., Prakash, K., Bansal, V. S., Meenakshi, J., & Amit, A. (2012) · American Journal of Plant Sciences · doi:10.4236/ajps.2012.327119 · Cited by 97 · see citing works
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Dietary seaweeds and obesity
Lange, K. W., Hauser, J., Nakamura, Y. K., & Kanaya, S. (2015) · Food Science and Human Wellness · doi:10.1016/j.fshw.2015.08.001 · Cited by 94 · see citing works
Aguamiel concentrate from Agave salmiana and its extracted saponins attenuated obesity and hepatic steatosis and increased Akkermansia muciniphila in C57BL6 mice
Leal‐Díaz, A. M., Noriega, L. G., Torre-Villalvazo, I., Torres, N., Alemán, G., López‐Romero, P., Sánchez‐Tapia, M., Aguilar‐López, M., Furuzawa‐Carballeda, J., Velázquez‐Villegas, L. A., et al. (2016) · Scientific Reports · doi:10.1038/srep34242 · Cited by 94 · see citing works
Inhibition of Gastrointestinal Lipolysis by Green Tea, Coffee, and Gomchui (Ligularia fischeri) Tea Polyphenols during Simulated Digestion
Hyun, K., Song, D., Kim, S. M., & Pan, C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf301047f · Cited by 91 · see citing works
Screening of the anthocyanin profile and in vitro pancreatic lipase inhibition by anthocyanin‐containing extracts of fruits, vegetables, legumes and cereals
Fabroni, S., Ballistreri, G., Amenta, M., Romeo, F. V., & Rapisarda, P. (2016) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7708 · Cited by 90 · see citing works
Ground green coffee beans as a functional food supplement – Preliminary study
Dziki, D., Gawlik‐Dziki, U., Pecio, Ł., Różyło, R., Świeca, M., Krzykowski, A., & Rudy, S. (2015) · LWT · doi:10.1016/j.lwt.2015.03.076 · Cited by 90 · see citing works
Anti-obesity effect of extract from fermentedCurcuma longaL. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats
Kim, J. H., Kim, O., Yoon, H., Park, J., You, Y., Kim, K., Lee, Y., Choi, K., Lee, J., & Jun, W. (2016) · Food & Nutrition Research · doi:10.3402/fnr.v60.30428 · Cited by 89 · see citing works
Study of Antiobesity Effect through Inhibition of Pancreatic Lipase Activity ofDiospyros kakiFruit andCitrus unshiuPeel
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Indole-Based Fibrates as Potential Hypolipidemic and Antiobesity Agents
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Metagenomics analysis of gut microbiota modulatory effect of green tea polyphenols by high fat diet-induced obesity mice model
Zhang, X., Zhang, M., Ho, C., Guo, X., Wu, Z., Weng, P., Yan, M., & Cao, J. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.05.003 · Cited by 88 · see citing works
Inhibitory mechanisms and interaction of tangeretin, 5-demethyltangeretin, nobiletin, and 5-demethylnobiletin from citrus peels on pancreatic lipase: Kinetics, spectroscopies, and molecular dynamics simulation.
Huang, X., Zhu, J.-X., Wang, L., Jing, H.-J., Ma, C.-Y., Kou, X.-R., & Wang, H.-X. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.305 · Cited by 76 · see citing works
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Lychee (Litchi chinensis Sonn.) seed water extract as potential antioxidant and anti-obese natural additive in meat products
Qi, S., Huang, H., Huang, J., Wang, Q., & Wei, Q. (2014) · Food Control · doi:10.1016/j.foodcont.2014.08.047 · Cited by 83 · see citing works
Pancreatic Lipase Inhibitory Activity of Phlorotannins Isolated from Eisenia bicyclis
Eom, S., Lee, M., Lee, E., Kim, Y., & Kim, T. H. (2012) · Phytotherapy Research · doi:10.1002/ptr.4694 · Cited by 82 · see citing works
In vitro α-amylase, α-glucosidase, lipase inhibitory and cytotoxic activities of tuber extracts of Kedrostis africana (L.) Cogn
Unuofin, J. O., Otunola, G. A., & Afolayan, A. J. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e00810 · Cited by 81 · see citing works
Lingual lipase activity in the orosensory detection of fat by humans
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Potential of rooibos, its majorC-glucosyl flavonoids, andZ-2-(β-D-glucopyranosyloxy)-3-phenylpropenoic acid in prevention of metabolic syndrome
Muller, C. J. F., Malherbe, C. J., Chellan, N., Yagasaki, K., Miura, Y., & Joubert, E. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1157568 · Cited by 80 · see citing works
Chlorogenic acid ameliorates obesity by preventing energy balance shift in high‐fat diet induced obese mice
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Authors: Yun, J. W.
Affiliations: Daegu University (KR)
Corresponding author: Yun, Jong Won
ORCID: Yun, Jong Won
Venue: Phytochemistry
Publisher: Elsevier BV
Published: 2010-10
Volume: 71
Issue: 14-15
Pages: 1625-1641
ISSN: 0031-9422 (ISSN-L)
DOI: 10.1016/j.phytochem.2010.07.011
OpenAlex: W2167277714
Cited by: 619
References: 294
Citations by year: 2026: 7 · 2025: 21 · 2024: 25 · 2023: 29 · 2022: 50 · 2021: 40 · 2020: 37 · 2019: 55 · 2018: 57 · 2017: 49 · 2016: 64 · 2015: 50 · 2014: 47 · 2013: 37 · 2012: 36
FWCI: 3.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Phytochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords: obesity, anti-obesity drugs, natural products, orlistat, sibutramine, pancreatic lipase inhibition, appetite suppressants, mechanism of action, obesity-related comorbidities
MeSH terms: Appetite Depressants, Biological Products, Energy Metabolism, Lipase, Obesity, Plants, Medicinal, Adipocytes, Anti-Obesity Agents, Lipid Metabolism

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