Cited by 871Pharmacology and Obesity TreatmentBioactive natural compoundsNatural Antidiabetic Agents Studies

Pancreatic lipase inhibitors from natural sources: Unexplored potential

Birari, Rahul B., Bhutani, Kamlesh K.·2007·Drug Discovery Today

Abstract

The prevalence of obesity is increasing at an alarming rate, but, unfortunately, only a few medications are currently on the market. Obesity is primarily regarded as a disorder of lipid metabolism and the enzymes involved in this process could be selectively targeted to develop antiobesity drugs. Recently, newer approaches for the treatment of obesity have involved inhibition of dietary triglyceride absorption via inhibition of pancreatic lipase (PL) as this is the major source of excess calories. Natural products provide a vast pool of PL inhibitors that can possibly be developed into clinical products. This article reviews various extracts and secondary metabolites from plants and microbial origin with PL inhibitory activity that can be focused for drug development programs.

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Crossref · 10.1016/j.drudis.2007.07.024

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Authors
Birari, R. B., & Bhutani, K. K.
Affiliations
National Institute of Pharmaceutical Education and Research (IN)
Corresponding author
Bhutani, Kamlesh K.
Venue
Drug Discovery Today
Publisher
Elsevier BV
Published
2007-10
Volume
12
Issue
19-20
Pages
879-889
ISSN
1359-6446 (ISSN-L)
OpenAlex
W2066197031
Cited by
871
References
63
Citations by year
2026: 25 · 2025: 39 · 2024: 45 · 2023: 71 · 2022: 59 · 2021: 68 · 2020: 52 · 2019: 58 · 2018: 59 · 2017: 59 · 2016: 54 · 2015: 57 · 2014: 56 · 2013: 58 · 2012: 39
FWCI
1.29
Type
journal article
Language
en
Open access
closed
Locations
  • Drug Discovery Today (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords
pancreatic lipase inhibitors, obesity, anti-obesity drugs, natural products, plant extracts, microbial secondary metabolites, lipid metabolism, drug development
MeSH terms
Biological Products, Flavonoids, Humans, Lactones, Lipase, Obesity, Pancreas, Phenols, Plant Extracts, Plants, Medicinal, Saponins, Terpenes, Lipid Metabolism, Polyphenols

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