Aureobasidins, new antifungal antibiotics. Taxonomy, fermentation, isolation, and properties.
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Aureobasidins A to R were isolated from the fermentation broth of Aureobasidium pullulans R106. Aureobasidins are cyclic depsipeptide antibiotics with MW's ranging from 1.070 to 1,148. Aureobasidins showed high in vitro antifungal activity against Candida albicans.
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Some A. pullulans metabolites (e.g., aureobasidins, liamocins, 2-propylacrylic acid, 2-methylenesuccinic acid) confer antagonistic activity against bacteria or fungi.
“Some of these metabolites (e.g., aureobasidins, liamocins, 2-propylacrylic acid, 2-methylenesuccinic acid) confer antagonistic activity against bacteria or fungi (Prasongsuk et al. 2018; Price et al. 2013, 2017; Takesako et al. 1991; Zain et al. 2009).”
From Biocontrol yeasts: mechanisms and applications (2019) · cites this paper as Takesako et al. 1991
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- Authors
- TAKESAKO, K., IKAI, K., HARUNA, F., ENDO, M., SHIMANAKA, K., SONO, E., NAKAMURA, T., KATO, I., & YAMAGUCHI, H.
- Affiliations
- Takara Shuzo Co., Ltd. (Japan) (JP)
- Teikyo University (JP)
- Venue
- The Journal of Antibiotics
- Published
- 1991
- Volume
- 44
- Issue
- 9
- Pages
- 919-924
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W1972180927
- Cited by
- 149
- References
- 11
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 8 · 2012: 3
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Antibiotics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Keywords
- Aureobasidium pullulans, antifungal activity, Candida albicans, fungal taxonomy, fermentation, natural product isolation, antibiotic properties
- MeSH terms
- Antifungal Agents, Candida albicans, Chemistry, Mitosporic Fungi, Fermentation, Microbial Sensitivity Tests, Chemical Phenomena
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