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Cited by 6Tuberculosis Research and EpidemiologyInfectious Diseases and TuberculosisDiagnosis and treatment of tuberculosis

Diagnostic yield of fine needle aspiration biopsy in HIV-infected adults with suspected mycobacterial lymphadenitis

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Razack, R, Louw, M, Wright, C A·2013·South African Medical Journal
DOI 10.7196/samj.7492
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Abstract

BACKGROUND: Fine needle aspiration biopsy (FNAB) has been shown to be the diagnostic procedure of choice for superficial lymphadenitis in tuberculosis endemic regions. METHODS: We conducted a retrospective laboratory-based study to determine the bacteriological yield of clinically suspected mycobacterial tuberculous lymphadenitis following FNAB in adults, and specifically HIV-positive patients, to determine the need for the introduction of automated nucleic acid amplification tests (NAATs) such as the Xpert MTB/RIF assay as the initial diagnostic modality. RESULTS. A diagnostic yield of 80% was achieved, significantly higher in HIV-positive v. HIV-negative patients (84% v. 52%, respectively; p<0.001). CONCLUSION: The results justify using automated NAATs such as the Xpert MTB/RIF assay as the initial diagnostic modality to expedite management in HIV-infected patients.

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  • FNA is increasingly being used worldwide as a first diagnostic step because of its ease and safety profile, although sensitivity is very variable depending on the study, with positive mycobacterial culture ranging from 10% to 80%.

    “FNA is increasingly being used worldwide as a first diagnostic step because of its ease and safety profile, although sensitivity is very variable depending on the study, with positive mycobacterial culture ranging from 10% to 80%.3,4,13–16”

    From Epidemiology and Diagnosis of Tuberculous Lymphadenitis in a Tuberculosis Low-Burden Country (2015) · cites this paper as [13]

    The Abstract describes FNAB as the diagnostic procedure of choice for tuberculous lymphadenitis and calls it simple and safe. It also reports variable positive mycobacterial culture detection across studies, but gives a range of 35%–83%, not 10%–80%. It does not establish that FNAB use is increasing worldwide. (LLM, conf=0.90)

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Authors
Razack, R., Louw, M., & Wright, C. A.
Affiliations
National Health Laboratory Service (ZA)
ORCID
Venue
South African Medical Journal
Publisher
South African Medical Association NPC
Published
2013-11-20
Volume
104
Issue
1
Pages
27
ISSN
  • 0256-9574 (ISSN-L)
  • 2078-5135
DOI
10.7196/samj.7492
OpenAlex
W2167040977
Cited by
6
References
15
Citations by year
2021: 1 · 2018: 1 · 2015: 3 · 2013: 1
FWCI
0.97
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • South African Medical Journal (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • SUNScholar (Stellenbosch University) (submittedVersion)
Funders
Universiteit Stellenbosch
Topics
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
  • Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
Keywords
fine-needle aspiration, mycobacterial lymphadenitis, tuberculous lymphadenitis, HIV infection, diagnostic yield, Xpert MTB/RIF, nucleic acid amplification tests, tuberculosis diagnosis, lymphadenopathy
MeSH terms
Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Retrospective Studies, Tuberculosis, Lymph Node, HIV Infections, Biopsy, Fine-Needle

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