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Identification of Alcohol Abuse Using Laboratory Tests and a History of Trauma
Abstract
In a study involving 68 ambulatory patients with known alcohol problems and 68 social drinkers matched for age and sex, a questionnaire about the patients' history of trauma identified 7 out of 10 subjects with drinking problems. In contrast, abnormal values for gamma-glutamyl transferase, mean corpuscular volume, or high-density lipoproteins had only moderate sensitivity (26% to 40%) for identifying alcohol problems but excellent specificity (88% to 99%) for ruling out cases. Similar rates of sensitivity and specificity were found among 61 family practice patients. Diagnostic accuracy was improved by combining tests results, using computer-based logistic regression analysis. This study suggests that a brief questionnaire on history of trauma is valuable for the earlier detection of problem drinking in ambulatory populations, in contrast to laboratory tests, which appear to have high sensitivity only with more chronic alcoholics.
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Cited by
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Sanyal, A. J., Chalasani, N., Kowdley, K. V., McCullough, A., Diehl, A. M., Bass, N. M., Neuschwander-Tetri, B. A., Lavine, J. E., Tonascia, J., Unalp, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907929 · Cited by 3,327
Clinical Prediction Rules: Applications and Methodological Standards
Wasson, J. H., Sox, H. C., Neff, R. K., & Goldman, L. (1985) · New England Journal of Medicine · doi:10.1056/nejm198509263131306 · Cited by 1,357
Babor, T. F., McRee, B. G., Kassebaum, P. A., Grimaldi, P. L., Ahmed, K., & Bray, J. (2007) · Substance Abuse · doi:10.1300/j465v28n03_03 · Cited by 1,100
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CONIGRAVE, K. M., HALL, W. D., & SAUNDERS, J. B. (1995) · Addiction · doi:10.1111/j.1360-0443.1995.tb03552.x · Cited by 549
Metadata
- Authors
- SKINNER, H. A., HOLT, S., SCHULLER, R., ROY, J., & ISRAEL, Y.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1984-12-01
- Volume
- 101
- Issue
- 6
- Pages
- 847-851
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2094171279
- Cited by
- 217
- References
- 0
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- SKINNER, H. A., HOLT, S., SCHULLER, R., ROY, J., & ISRAEL, Y. (1984). Identification of Alcohol Abuse Using Laboratory Tests and a History of Trauma. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-101-6-847
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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