The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Evidence for Early Central Nervous System Involvement in the Acquired Immunodeficiency Syndrome (AIDS) and Other Human Immunodeficiency Virus (HIV) Infections: Studies with Neuropsychologic Testing and Magnetic Resonance Imaging
Abstract
Although a high prevalence of central nervous system disease is seen in persons with the acquired immunodeficiency syndrome (AIDS), the natural history of brain involvement with human immunodeficiency virus (HIV) remains poorly understood. Neuropsychologic evaluations of 55 ambulatory homosexual men revealed abnormalities in 13 of 15 with AIDS, 7 of 13 [corrected] with AIDS-related complex, 7 of 16 [corrected] with HIV-seropositivity only, and 1 of 11 with HIV-seronegativity. Common neuropsychologic problems included impaired abstracting ability, learning difficulties, and slowed speed of information processing. Magnetic resonance imaging had abnormal findings in 9 of 13 patients with AIDS and 5 of 10 patients with AIDS-related complex who were available for scans. The commonest abnormalities were sulcal and ventricular enlargement and bilateral patchy areas of high signal intensity in the white matter. We postulate that central nervous system involvement by HIV may begin early in the course of AIDS and cause mild cognitive deficits in otherwise asymptomatic persons.
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Citations
Cites
Paced Auditory Serial-Addition Task: A Measure of Recovery from Concussion
Gronwall, D. M. A. (1977) · Perceptual and Motor Skills · doi:10.2466/pms.1977.44.2.367 · Cited by 2,395
Cited by
Groups, F. T. C. A. H., Heaton, R. K., Franklin, D. R., Ellis, R. J., McCutchan, J. A., Letendre, S. L., LeBlanc, S., Corkran, S. H., Duarte, N. A., Clifford, D. B., et al. (2011) · Journal of NeuroVirology · doi:10.1007/s13365-010-0006-1 · Cited by 1,533
Self-citationThe Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia Complex
Price, R. W., Brew, B., Sidtis, J., Rosenblum, M., Scheck, A. C., & Cleary, P. (1988) · Science · doi:10.1126/science.3277272 · Cited by 1,245
The HNRC 500-Neuropsychology of Hiv infection at different disease stages
Heaton, R. K., Grant, I., Butters, N., White, D. A., Kirson, D., Atkinson, J. H., McCutchan, J. A., Taylor, M. J., Kelly, M. D., Ellis, R. J., et al. (1995) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617700000230 · Cited by 631
Self-citationCognitive Neuropsychology of HIV-Associated Neurocognitive Disorders
Woods, S. P., Moore, D. J., Weber, E., & Grant, I. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9102-5 · Cited by 573
Self-citationHIV and antiretroviral therapy in the brain: neuronal injury and repair
Ellis, R., Langford, D., & Masliah, E. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2040 · Cited by 517
Metadata
- Authors
- GRANT, I., ATKINSON, J. H., HESSELINK, J. R., KENNEDY, C. J., RICHMAN, D. D., SPECTOR, S. A., & McCUTCHAN, J. A.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1987-12-01
- Volume
- 107
- Issue
- 6
- Pages
- 828-836
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2125417887
- Cited by
- 582
- References
- 1
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Evidence for Early Central Nervous System Involvement in the Acquired Immunodeficiency Syndrome (AIDS) and Other Human Immunodeficiency Virus (HIV) Infections: Studies with Neuropsychologic Testing and Magnetic Resonance Imaging. https://app.cochat.ai/papers/10.7326/0003-4819-107-6-828
- The paper
- GRANT, I., ATKINSON, J. H., HESSELINK, J. R., KENNEDY, C. J., RICHMAN, D. D., SPECTOR, S. A., & McCUTCHAN, J. A. (1987). Evidence for Early Central Nervous System Involvement in the Acquired Immunodeficiency Syndrome (AIDS) and Other Human Immunodeficiency Virus (HIV) Infections: Studies with Neuropsychologic Testing and Magnetic Resonance Imaging. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-107-6-828
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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