The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Trimethoprim-Sulfamethoxazole Compared with Pentamidine for Treatment of Pneumocystis carinii Pneumonia in the Acquired Immunodeficiency Syndrome: A Prospective, Noncrossover Study
Abstract
STUDY OBJECTIVE: To ascertain the efficacy and toxicity of trimethoprim-sulfamethoxazole or pentamidine when either is given alone during the entire treatment period for Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome (AIDS). DESIGN: Prospective, randomized, noncrossover comparison of trimethoprim-sulfamethoxazole with pentamidine. Trimethoprim-sulfamethoxazole dosage was adjusted to maintain serum trimethoprim at 5 to 8 micrograms/mL. Pentamidine dosage was reduced by 30% to 50% for an absolute rise in serum creatinine of more than 88 mumol/L (1 mg/dL). SETTING: Tertiary care hospital and AIDS clinic. PATIENTS: Thirty-six patients were treated with trimethoprim-sulfamethoxazole and 34 with pentamidine. Pretreatment clinical features and laboratory test results were similar in the two groups. MEASUREMENTS AND MAIN RESULTS: Thirty-six recipients of trimethoprim-sulfamethoxazole and 33 recipients of pentamidine completed therapy without crossover. Trimethoprim-sulfamethoxazole caused a rash (44%) and anemia (39%) more frequently (P less than or equal to 0.03, whereas pentamidine caused nephrotoxicity (64%), hypotension (27%), or hypoglycemia (21%) more frequently (P less than or equal to 0.01). The (A - a)DO2 improved by greater than 1.3 kPa (10 mmHg) 8 days earlier for trimethoprim-sulfamethoxazole recipients (95% CI for the difference in response, -1 to 17; P = 0.04). Thirty-one (86%) patients treated with trimethoprim-sulfamethoxazole and 20 (61%) with pentamidine survived and were without respiratory support at completion of treatment (95% CI for the difference in response, 5% to 45%; P = 0.03). CONCLUSIONS: For most patients with AIDS and P. carinii pneumonia, successful treatment with a single agent is possible. Toxicity associated with the two standard treatments is rarely life-threatening and may be diminished if the trimethoprim-sulfamethoxazole dosage is modified by pharmacokinetic monitoring and the pentamidine dosage is reduced for nephrotoxicity. Oxygenation improved more quickly and survival was better with trimethoprim-sulfamethoxazole.
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KOVACS, J. A., HIEMENZ, J. W., MACHER, A. M., STOVER, D., MURRAY, H. W., SHELHAMER, J., LANE, H. C., URMACHER, C., HONIG, C., LONGO, D. L., et al. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-100-5-663 · Cited by 855
GORDIN, F. M., SIMON, G. L., WOFSY, C. B., & MILLS, J. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-100-4-495 · Cited by 704
Murray, J. F., Felton, C. P., Garay, S. M., Gottlieb, M. S., Hopewell, P. C., Stover, D. E., & Teirstein, A. S. (1984) · New England Journal of Medicine · doi:10.1056/nejm198406213102529 · Cited by 687
WHARTON, J. M., COLEMAN, D. L., WOFSY, C. B., LUCE, J. M., BLUMENFELD, W., HADLEY, W. K., INGRAM-DRAKE, L., VOLBERDING, P. A., & HOPEWELL, P. C. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-1-37 · Cited by 376
Sands, M., Kron, M. A., & Brown, R. B. (1985) · Clinical Infectious Diseases · doi:10.1093/clinids/7.5.625 · Cited by 348
Hughes, W. T., Feldman, S., Chaudhary, S. C., Ossi, M. J., Cox, F., & Sanyal, S. K. (1978) · The Journal of Pediatrics · doi:10.1016/s0022-3476(78)80028-6 · Cited by 241
Allegra, C. J., Chabner, B. A., Tuazon, C. U., Ogata-Arakaki, D., Baird, B., Drake, J. C., Simmons, J. T., Lack, E. E., Shelhamer, J. H., Balis, F., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198710153171602 · Cited by 234
Jaffe, H., Ammann, A., Abrams, D., Lewis, B., & Golden, J. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90627-x · Cited by 222
Brenner, M., Ognibene, F. P., Lack, E. E., Simmons, J. T., Suffredini, A. F., Lane, H. C., Fauci, A. S., Parrillo, J. E., Shelhamer, J. H., & Masur, H. (1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.5.1199 · Cited by 158
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Cited by
Colonization by Pneumocystis jirovecii and Its Role in Disease
Morris, A., & Norris, K. A. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00013-12 · Cited by 429
Trimethoprim-Sulfamethoxazole Revisited
Masters, P. A., O'Bryan, T. A., Zurlo, J., Miller, D. Q., & Joshi, N. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.4.402 · Cited by 408
Medina, I., Mills, J., Leoung, G., Hopewell, P. C., Lee, B., Modin, G., Benowitz, N., & Wofsy, C. B. (1990) · New England Journal of Medicine · doi:10.1056/nejm199009203231202 · Cited by 320
Cooley, L., Dendle, C., Wolf, J., Teh, B. W., Chen, S. C., Boutlis, C., & Thursky, K. A. (2014) · Internal Medicine Journal · doi:10.1111/imj.12599 · Cited by 228
Walzer, P. D., Foy, J., Steele, P., Kim, C. K., White, M., Klein, R. S., Otter, B. A., & Allegra, C. (1992) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.36.9.1935 · Cited by 67
Metadata
- Authors
- Sattler, F. R., Cowan, R., Nielsen, D. M., & Ruskin, J.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1988-08-15
- Volume
- 109
- Issue
- 4
- Pages
- 280-287
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W1973136343
- Cited by
- 360
- References
- 13
- FWCI
- 28.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sattler, F. R., Cowan, R., Nielsen, D. M., & Ruskin, J. (1988). Trimethoprim-Sulfamethoxazole Compared with Pentamidine for Treatment of Pneumocystis carinii Pneumonia in the Acquired Immunodeficiency Syndrome: A Prospective, Noncrossover Study. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-109-4-280
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