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Cited by 503

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Illnesses Associated with Escherichia coli 0157:H7 Infections: A Broad Clinical Spectrum

Griffin, Patricia M., Ostroff, Stephen M., Tauxe, Robert V., Greene, Katherine D., Wells, Joy G., Lewis, Jay H., Blake, Paul A.·1988·Annals of Internal Medicine
DOI 10.7326/0003-4819-109-9-705
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Abstract

STUDY OBJECTIVE: To describe the spectrum of illnesses associated with Escherichia coli O157:H7 infections. DESIGN: Described an outbreak that showed the broad spectrum of these infections. Reviewed the clinical findings in the other eight major outbreaks reported between 1982 and 1986. Also reviewed reports of sporadic cases. SETTING: Outbreaks in communities, nursing homes, a day care center, and a kindergarten. CASES: Persons identified in outbreaks of E. coli O157:H7 infections. RESULTS: Escherichia coli O157:H7 infection causes bloody diarrhea (hemorrhagic colitis), nonbloody diarrhea, the hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Infection can be asymptomatic, can involve extraintestinal sites, and can be fatal. Bloody diarrhea is the commonest symptom. Most patients have severe abdominal cramps; fever is documented in less than half. Findings from fecal leukocyte examinations often suggest a noninfectious cause. Results of radiologic and colonoscopic examinations can be consistent with a diagnosis of inflammatory bowel disease or ischemic colitis. Patients at the extremes of age are at increased risk for E. coli O157:H7-associated diarrhea, the hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, and death. Antimicrobial agents have not been shown to modify the illness, but there are few data on individual agents. CONCLUSION: Infection with E. coli O157:H7 should be considered in all patients with bloody diarrhea, the hemolytic uremic syndrome, or thrombotic thrombocytopenic purpura because the infection can masquerade as gastrointestinal bleeding of noninfectious cause, the antecedent diarrhea may be resolved and forgotten by the time the hemolytic uremic syndrome or thrombotic thrombocytopenic purpura is diagnosed, and the detection of E. coli O157:H7 requires specific stool culture techniques.

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Metadata

Authors
Griffin, P. M., Ostroff, S. M., Tauxe, R. V., Greene, K. D., Wells, J. G., Lewis, J. H., & Blake, P. A.
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
1988-11-01
Volume
109
Issue
9
Pages
705-712
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-109-9-705
OpenAlex
W1970347595
Cited by
503
References
12
FWCI
7.59
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Illnesses Associated with Escherichia coli 0157:H7 Infections: A Broad Clinical Spectrum. https://app.cochat.ai/papers/10.7326/0003-4819-109-9-705
The paper
Griffin, P. M., Ostroff, S. M., Tauxe, R. V., Greene, K. D., Wells, J. G., Lewis, J. H., & Blake, P. A. (1988). Illnesses Associated with Escherichia coli 0157:H7 Infections: A Broad Clinical Spectrum. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-109-9-705

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.