The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Polycystic Ovary Syndrome: Pathogenesis and Treatment
Abstract
PURPOSE: To propose a theory for the pathogenesis of the polycystic ovary syndrome that explains the endocrinologic abnormalities of the syndrome and provides a rational approach to therapy. DATA IDENTIFICATION: An English-language literature search using MEDLINE (1975 to 1988) and extensive bibliographic reviews of identified articles. STUDY SELECTION: We reviewed the literature and selected 169 articles considered most relevant for the definition of the endocrinologic abnormalities, elucidation of pathogenic mechanisms, or delineation of therapeutic interventions. DATA EXTRACTION: The authors independently assessed study quality and data concerning endocrinologic abnormalities, pathogenic mechanisms, and therapy of the polycystic ovary syndrome. RESULTS OF DATA SYNTHESIS: The polycystic ovary syndrome may be best defined as functional, gonadotropin-dependent ovarian hyperandrogenism. The polycystic ovary syndrome results when a primary defect increases one of three variables: the ratio of the serum concentrations of luteinizing hormone to follicle stimulating hormone, the ratio of the intraovarian concentrations of androgen to estrogen, or follicular atresia. An increase in one of these variables can then induce successive abnormalities in one or more of the remaining two variables in a to-and-fro manner. CONCLUSIONS: Evidence suggests that several causes exist, each of which can produce the clinical syndrome by a to-and-fro interaction among pathogenic mechanisms. Treatment objectives for the syndrome include amelioration of hirsutism, induction of ovulation, and weight reduction.
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Cites
McNATTY, K. P., SMITH, D. M., MAKRIS, A., OSATHANONDH, R., & RYAN, K. J. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-49-6-851 · Cited by 522
Progesterone Modulation of Pulsatile Luteinizing Hormone Secretion in Normal Women*
SOULES, M. R., STEINER, R. A., CLIFTON, D. K., COHEN, N. L., AKSEL, S., & BREMNER, W. J. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-58-2-378 · Cited by 319
PANG, S., LERNER, A. J., STONER, E., LEVINE, L. S., OBERFIELD, S. E., ENGEL, I., & NEW, M. I. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-3-428 · Cited by 238
Late-onset adrenal hyperplasia in hirsutism
Kuttenn, F., Couillin, P., Girard, F., Billaud, L., Vincens, M., Boucekkine, C., Thalabard, J.-C., Maudelonde, T., Spritzer, P., Mowszowicz, I., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198507253130404 · Cited by 213
Neuroendocrine-gonadal axis in men: frequent sampling of LH, FSH, and testosterone
Spratt, D. I., O'Dea, L. S., Schoenfeld, D., Butler, J., Rao, P. N., & Crowley, W. F. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.254.5.e658 · Cited by 194
CHROUSOS, G. P., LORIAUX, D. L., MANN, D. L., & CUTLER, G. B. (1982) · Annals of Internal Medicine · doi:10.7326/0003-4819-96-2-143 · Cited by 158
Clinical and Biological Phenotypes in Late-Onset 21 Hydroxylase Deficiency
DEWAILLY, D., VANTYGHEM-HAUDIQUET, M.-C., SAINSARD, C., BUVAT, J., CAPPOEN, J. P., ARDAENS, K., RACADOT, A., LEFEBVRE, J., & FOSSATI, P. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-2-418 · Cited by 151
Pubertal Presentation of Congenital Δ5–-3β–Hydroxysteroid Dehydrogenase Deficiency*
ROSENFIELD, R. L., RICH, B. H., WOLFSDORF, J. I., CASSORLA, F., PARKS, J. S., BONGIOVANNI, A. M., WU, C. H., & SHACKLETON, C. H. L. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-2-345 · Cited by 135
Self-citationGenetic and Hormonal Characterization of Cryptic 21-Hydroxylase Deficiency*
LEVINE, L. S., DUPONT, B., LORENZEN, F., PANG, S., POLLACK, M., OBERFIELD, S. E., KOHN, B., LERNER, A., CACCIARI, E., MANTERO, F., et al. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-6-1193 · Cited by 81
Cited by
The Cardinal Manifestations of Bardet–Biedl Syndrome, a Form of Laurence–Moon–Biedl Syndrome
Green, J. S., Parfrey, P. S., Harnett, J. D., Farid, N. R., Cramer, B. C., Johnson, G., Heath, O., McManamon, P. J., O'Leary, E., & Pryse-Phillips, W. (1989) · New England Journal of Medicine · doi:10.1056/nejm198910123211503 · Cited by 555
Mortality of Women with Polycystic Ovary Syndrome at Long-term Follow-up
Pierpoint, T., McKeigue, P. M., Isaacs, A. J., Wild, S. H., & Jacobs, H. S. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00035-3 · Cited by 504
Nelson, V. L., Qin, K.-N., Rosenfield, R. L., Wood, J. R., Penning, T. M., Legro, R. S., Strauss, J. F., & McAllister, J. M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8088 · Cited by 405
Self-citationIbañez, L., Potau, N., Virdis, R., Zampolli, M., Terzi, C., Gussinyé, M., Carrascosa, A., & Vicens-Calvet, E. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.6.8501168 · Cited by 341
Genetics of polycystic ovary syndrome: searching for the way out of the labyrinth
Diamanti-Kandarakis, E., & Piperi, C. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi025 · Cited by 167
Metadata
- Authors
- Barnes, R., & Rosenfield, R. L.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1989-03-01
- Volume
- 110
- Issue
- 5
- Pages
- 386-399
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2007563635
- Cited by
- 163
- References
- 9
- FWCI
- 12.33
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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