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Cited by 319Hypothalamic control of reproductive hormonesOvarian function and disordersReproductive Biology and Fertility

Progesterone Modulation of Pulsatile Luteinizing Hormone Secretion in Normal Women*

SOULES, MICHAEL R., STEINER, ROBERT A., CLIFTON, DONALD K., COHEN, NANCY L., AKSEL, SEZER, BREMNER, WILLIAM.J·1984·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-58-2-378
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Abstract

Recent studies show that the frequency and amplitude of pulsatile LH secretion change during the normal human menstrual cycle; however, the neuroendocrine mechanisms underlying these changes are poorly understood. To assess the role of progesterone (P) in regulating LH secretion patterns, we treated normal women (n = 5) with im P in oil during the follicular phase of their cycle and compared LH pulse frequency, amplitude, and mean plasma level during treatment to those in normal cycling women. Normal women were studied five times in five menstrual cycles. Each study lasted 24 h, with a sampling interval of 20 min. The cycle phases studied were early follicular (twice), late follicular (LF), midluteal, and LF with P therapy to simulate luteal phase plasma P levels. LH pulse frequency was slower (P less than or equal to 0.001) in the midluteal phase than in either the early follicular phase or LF, and furthermore, P, administered in the normal follicular phase, slowed LH pulse frequency, augmented pulse amplitude, and reduced mean plasma LH levels compared to those in untreated women studied at the same cycle phase (P less than or equal to 0.02). We infer that P secretion by the ovary mediates the change in the LH secretory pattern during the luteal phase of the normal menstrual cycle, and that at least part of this effect is mediated by the central nervous system.

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Crossref · 10.1210/jcem-58-2-378

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  • Normal women have reproducible and stable LH pulse frequencies in the early follicular phase of the menstrual cycle when frequent sampling (every 10 min) is performed.

    “Normal women have been shown to have reproducible and stable LH pulse frequencies in the early follicular phase of the menstrual cycle [32] when frequent sampling (every 10 min) is performed [33].”

    From Suppression of the Hypothalamic-Pituitary-Ovarian Axis in Normal Women by Glucocorticoids1 (1993) · cites this paper as [32]

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Authors
SOULES, M. R., STEINER, R. A., CLIFTON, D. K., COHEN, N. L., AKSEL, S., & BREMNER, W. J.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1984-02
Volume
58
Issue
2
Pages
378-383
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-58-2-378
OpenAlex
W2127309304
Cited by
319
References
23
Citations by year
2026: 6 · 2025: 4 · 2024: 3 · 2023: 11 · 2022: 13 · 2021: 8 · 2020: 10 · 2019: 13 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 5 · 2012: 2
FWCI
16.11
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • ResearchWorks at the University of Washington (University of Washington) (submittedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD012629)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
progesterone, luteinizing hormone secretion, pulsatile LH secretion, LH pulse frequency, LH pulse amplitude, menstrual cycle, luteal phase, follicular phase, progesterone therapy, neuroendocrine regulation, hypothalamic-pituitary-gonadal axis
MeSH terms
Adult, Estradiol, Female, Follicular Phase, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Menstruation, Progesterone

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